Reference ranges for sphingosine-1-phosphate in neonates
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Chinedu Ulrich Ebenebe
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Mirjam von Lucadou
Abstract
Objectives
Sphingosine-1-phosphate (S1P) is a signalling lipid involved in embryonic development, physiological homeostasis, and pathogenic processes in multiple organ systems. Disturbance of S1P homeostasis has been associated with various human diseases in which the immune response and vascular integrity are severely compromised. Up-to-date, no study has analyzed S1P levels in neonates. The objective of this study was to determine S1P serum concentrations in neonates and establish S1P reference ranges.
Methods
S1P levels in the umbilical cord blood of 460 term and preterm neonates were compared to a previously described cohort of healthy adult blood donors. S1P levels were further correlated with demographic characteristics, cellular sources of S1P, and inflammatory markers.
Results
The median S1P serum level in neonates was 1.70 μmol/L (IQR 1.41–1.97 μmol/L) and significantly higher than normal values reported in adults. S1P levels correlated positively with the number of red blood cells (p<0.001) and negatively with neutrophil precursors (p=0.028).
Conclusions
Elevated S1P levels in neonates compared to adults possibly result from higher S1P content in its cellular sources due to the essential role of S1P during embryogenesis. Generated S1P ranges may be used as reference ranges for future studies in neonates.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: The study protocol was approved by the Ethics Committee of the local medical chamber of Hamburg.
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/jpm-2020-0536).
© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
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- Introduction to the cesarean section articles
- Highlight Section: Cesarean Section
- Three kinds of caesarean sections: the foetal/neonatal perspective
- The neonatal respiratory morbidity associated with early term caesarean section – an emerging pandemic
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- Nationwide implementation of a decision aid on vaginal birth after cesarean: a before and after cohort study
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- Corner of Academy
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- Original Articles
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- Reference ranges for sphingosine-1-phosphate in neonates
Artikel in diesem Heft
- Frontmatter
- Editorial
- Introduction to the cesarean section articles
- Highlight Section: Cesarean Section
- Three kinds of caesarean sections: the foetal/neonatal perspective
- The neonatal respiratory morbidity associated with early term caesarean section – an emerging pandemic
- Vaginal birth after cesarean (VBAC): fear it or dare it? An evaluation of potential risk factors
- Nationwide implementation of a decision aid on vaginal birth after cesarean: a before and after cohort study
- Induction of labor at 39 weeks and risk of cesarean delivery among obese women: a retrospective propensity score matched study
- Cervical ripening after cesarean section: a prospective dual center study comparing a mechanical osmotic dilator vs. prostaglandin E2
- An evidence-based cesarean section suggested for universal use
- Online survey on uterotomy closure techniques in caesarean section
- Analysis of cesarean section rates in two German hospitals applying the 10-Group Classification System
- Reviews
- Pregnancy in incarcerated women: need for national legislation to standardize care
- Imaging diagnosis and legal implications of brain injury in survivors following single intrauterine fetal demise from monochorionic twins – a review of the literature
- Mini Review
- Professionally responsible management of the ethical and social challenges of antenatal screening and diagnosis of β-thalassemia in a high-risk population
- Opinion Paper
- Teaching and training the total percutaneous fetoscopic myelomeningocele repair
- Corner of Academy
- Chronic hypertension in pregnancy: synthesis of influential guidelines
- Original Articles
- The effects of pre-pregnancy obesity and gestational weight gain on maternal lipid profiles, fatty acids and insulin resistance
- Determination of organic pollutants in meconium and its relationship with fetal growth. Case control study in Northwestern Spain
- Betamethasone as a potential treatment for preterm birth associated with sterile intra-amniotic inflammation: a murine study
- Diagnostic accuracy of modified Hadlock formula for fetal macrosomia in women with gestational diabetes and pregnancy weight gain above recommended
- Vasa previa: when antenatal diagnosis can change fetal prognosis
- Mode of delivery and adverse short- and long-term outcomes in vertex-presenting very preterm born infants: a European population-based prospective cohort study
- Short Communication
- Reference ranges for sphingosine-1-phosphate in neonates
