Maturation of the cardiac autonomic regulation system, as function of gestational age in a cohort of low risk preterm infants born between 28 and 32 weeks of gestation
-
Israeli-Mendlovic Hadas
,
Zuk Luba
Abstract
Objectives
The maturation of the sympathetic nervous system (SNS) occurs steadily throughout gestation while the myelinated vagus has accelerated maturation periods, between 25 and 32 weeks of gestation and a further increase around 37–38 weeks of gestation. The aim was to quantify the cardiac autonomic regulation maturation, as a function of gestational age (GA) in a cohort of low risk preterm infants born between 28 and 32 weeks of gestation by assessing heart rate variability (HRV) at week 32, and at week 35 postmenstrual age (PMA).
Methods
Forty preterm infants were recruited, 24 h recordings of breathing rate and RR intervals were obtained at week 32 and week 35 PMA.
Results
A significant difference was noted between preterm infants born before 32 weeks GA and preterm infants born at week 32; the latter present higher HRV values throughout the follow-up period. No significant change over time was noted for the parasympathetic HRV measures while a significant increase was found in the sympathetic system. Moreover, a significant interaction effect of time and system was found, the increase in values of the sympathetic system over time was significantly larger than the change noted in the vagal HRV measures.
Conclusions
Given the beneficial influence of vagal tone on health and developmental outcomes in preterm infants, the findings of the current study highlight the need for further studies on the impact of specifics gestational age on vagal development and later assessing interventions associate with its continue development and maturation at these specific periods.
Research funding: None declared.
Author contributions: This work was performed in partial fulfillment of the requirements for a PhD degree of Hadas Israeli-Mendlovic, Sackler Faculty of Medicine, Tel Aviv University, Israel. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all individuals included in this study.
Ethical approval: The Shaare Zedek Medical Center Helsinki Review Board granted ethical approval (ethical approval number 0144-16-SZMC), and Tel Aviv University approved the study protocol.
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© 2021 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Review
- Neonatal lupus erythematosus – practical guidelines
- Original Articles – Obstetrics
- Optimal timing to screen for asymptomatic bacteriuria during pregnancy: first vs. second trimester
- Amniotic fluid embolism – implementation of international diagnosis criteria and subsequent pregnancy recurrence risk
- COL1A1, COL4A3, TIMP2 and TGFB1 polymorphisms in cervical insufficiency
- Pregnancy and neonatal outcomes of twin pregnancies – the role of maternal age
- Comparison of maternal third trimester hemodynamics between singleton pregnancy and twin pregnancy
- Daily monitoring of vaginal interleukin 6 as a predictor of intraamniotic inflammation after preterm premature rupture of membranes – a new method of sampling studied in a prospective multicenter trial
- Association between the number of pulls and adverse neonatal/maternal outcomes in vacuum-assisted delivery
- Original Articles – Fetus
- The effect of nuchal umbilical cord on fetal cardiac and cerebral circulation-cross-sectional study
- Recognition of facial expression of fetuses by artificial intelligence (AI)
- Correlation of first-trimester thymus size with chromosomal anomalies
- Fetal intracranial structures: differences in size according to sex
- Original Articles – Neonates
- Antenatal care and perinatal outcomes of asylum seeking women and their infants
- Maturation of the cardiac autonomic regulation system, as function of gestational age in a cohort of low risk preterm infants born between 28 and 32 weeks of gestation
- Short Communication
- The impact of transfers from neonatal intensive care to paediatric intensive care
- Letter to the Editor
- Differential microRNA expression in placentas of small-for-gestational age neonates with and without exposure to poor maternal gestational weight gain
Artikel in diesem Heft
- Frontmatter
- Review
- Neonatal lupus erythematosus – practical guidelines
- Original Articles – Obstetrics
- Optimal timing to screen for asymptomatic bacteriuria during pregnancy: first vs. second trimester
- Amniotic fluid embolism – implementation of international diagnosis criteria and subsequent pregnancy recurrence risk
- COL1A1, COL4A3, TIMP2 and TGFB1 polymorphisms in cervical insufficiency
- Pregnancy and neonatal outcomes of twin pregnancies – the role of maternal age
- Comparison of maternal third trimester hemodynamics between singleton pregnancy and twin pregnancy
- Daily monitoring of vaginal interleukin 6 as a predictor of intraamniotic inflammation after preterm premature rupture of membranes – a new method of sampling studied in a prospective multicenter trial
- Association between the number of pulls and adverse neonatal/maternal outcomes in vacuum-assisted delivery
- Original Articles – Fetus
- The effect of nuchal umbilical cord on fetal cardiac and cerebral circulation-cross-sectional study
- Recognition of facial expression of fetuses by artificial intelligence (AI)
- Correlation of first-trimester thymus size with chromosomal anomalies
- Fetal intracranial structures: differences in size according to sex
- Original Articles – Neonates
- Antenatal care and perinatal outcomes of asylum seeking women and their infants
- Maturation of the cardiac autonomic regulation system, as function of gestational age in a cohort of low risk preterm infants born between 28 and 32 weeks of gestation
- Short Communication
- The impact of transfers from neonatal intensive care to paediatric intensive care
- Letter to the Editor
- Differential microRNA expression in placentas of small-for-gestational age neonates with and without exposure to poor maternal gestational weight gain
