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Methods of detection and prevention of preterm labour and the PAMG-1 detection test: a review

  • Vincent Dochez EMAIL logo , Guillaume Ducarme , Pauline Gueudry , Yolaine Joueidi , Marion Boivin , Louise Boussamet , Hélène Pelerin , Aurélie Le Thuaut , Zeineb Lamoureux , Valéry-Pierre Riche , Norbert Winer , Thibault Thubert and Emilie Marie
Published/Copyright: October 2, 2020
Journal of Perinatal Medicine
From the journal Journal of Perinatal Medicine Volume 49 Issue 2

Abstract

Objectives

Preterm labour is the leading cause of hospitalization during pregnancy. In France, it results in more than 60,000 births before 37 weeks of gestation every year. Recent studies suggest that detection of placental α-microglobulin-1 (PAMG-1) in vaginal secretions among women presenting symptoms of preterm labour with intact membranes has good predictive value for the onset of spontaneous preterm delivery within 7 days. The test is especially interesting, in that the repetition of antenatal corticosteroids for foetal lung maturation is no longer recommended in France and the effect of the initial administration is most beneficial in the 24 h to 7 days afterwards.

Methods

We included all studies listed in PubMed and clinicaltrials.gov with the terms “PAMG-1” and either “preterm labor” or “preterm labour”, while excluding all studies on the subject of “rupture of the membranes” from 2000 through 2017. Ten studies were thus included.

Results

In women who had both the PAMG-1 and foetal fibronectin test, the PAMG-1 test was statistically superior to the measurement of cervical length for positive predictive value (p<0.0074), negative predictive value (p=0.0169) and specificity (p<0.001) for the prediction of spontaneous preterm delivery within 7 days.

Conclusions

The use of PAMG-1 may make it possible to target the women at risk with a shortened cervix on ultrasound (<25 mm) those with an imminent preterm delivery and therefore to adapt management, especially the administration of antenatal corticosteroid therapy.

Keywords: antenatal corticosteroid; cervical length; foetal fibronectin; PartoSure; placental α-microglobulin-1 (PAMG-1); preterm birth; preterm labour; threatened preterm delivery
Corresponding author: Vincent Dochez, Service de Gynécologie-Obstétrique, CHU de Nantes, Nantes, France, Tel: +33 2 40 08 78 00, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest. Vincent Dochez is a reviewer of this journal.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

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Received: 2020-06-21
Accepted: 2020-09-11
Published Online: 2020-10-02
Published in Print: 2021-02-23

© 2020 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. Methods of detection and prevention of preterm labour and the PAMG-1 detection test: a review
  4. Corner of Academy
  5. Long term alterations of growth after antenatal steroids in preterm twin pregnancies
  6. Original Articles – Obstetrics
  7. SARS-CoV-2 in pregnancy: maternal and perinatal outcome data of 34 pregnant women hospitalised between May and October 2020
  8. Comparison of hematological parameters and perinatal outcomes between COVID-19 pregnancies and healthy pregnancy cohort
  9. The effect of mask use on maternal oxygen saturation in term pregnancies during the COVID-19 process
  10. Risk factors for pregnancy-associated venous thromboembolism in Singapore
  11. Does the length of second stage of labour or second stage caesarean section in nulliparous women increase the risk of preterm birth in subsequent pregnancies?
  12. Reference range for C1-esterase inhibitor (C1 INH) in the third trimester of pregnancy
  13. Termination of pregnancy following a Down Syndrome diagnosis: decision-making process and influential factors in a Muslim but secular country, Turkey
  14. High dose vs. low dose oxytocin for labor augmentation: a systematic review and meta-analysis of randomized controlled trials
  15. Extremely high levels of alkaline phosphatase and pregnancy outcome: case series and review of the literature
  16. Cervical elastography strain ratio and strain pattern for the prediction of a successful induction of labour
  17. Original Articles – Fetus
  18. CD34 immunostain increases sensitivity of the diagnosis of fetal vascular malperfusion in placentas from ex-utero intrapartum treatment
  19. The ability of various cerebroplacental ratio thresholds to predict adverse neonatal outcomes in term fetuses exhibiting late-onset fetal growth restriction
  20. Obstetric and pediatric growth charts for the detection of late-onset fetal growth restriction and neonatal adverse outcomes
  21. Original Articles – Neonates
  22. Bacterial stability with freezer storage of human milk
  23. Protein and genetic expression of CDKN1C and IGF2 and clinical features related to human umbilical cord length
  24. Short Communication
  25. A considerable asymptomatic proportion and thromboembolism risk of pregnant women with COVID-19 infection in Wuhan, China
https://doi.org/10.1515/jpm-2020-0289
Keywords for this article
antenatal corticosteroid; cervical length; foetal fibronectin; PartoSure; placental α-microglobulin-1 (PAMG-1); preterm birth; preterm labour; threatened preterm delivery

Articles in the same Issue

  1. Frontmatter
  2. Review
  3. Methods of detection and prevention of preterm labour and the PAMG-1 detection test: a review
  4. Corner of Academy
  5. Long term alterations of growth after antenatal steroids in preterm twin pregnancies
  6. Original Articles – Obstetrics
  7. SARS-CoV-2 in pregnancy: maternal and perinatal outcome data of 34 pregnant women hospitalised between May and October 2020
  8. Comparison of hematological parameters and perinatal outcomes between COVID-19 pregnancies and healthy pregnancy cohort
  9. The effect of mask use on maternal oxygen saturation in term pregnancies during the COVID-19 process
  10. Risk factors for pregnancy-associated venous thromboembolism in Singapore
  11. Does the length of second stage of labour or second stage caesarean section in nulliparous women increase the risk of preterm birth in subsequent pregnancies?
  12. Reference range for C1-esterase inhibitor (C1 INH) in the third trimester of pregnancy
  13. Termination of pregnancy following a Down Syndrome diagnosis: decision-making process and influential factors in a Muslim but secular country, Turkey
  14. High dose vs. low dose oxytocin for labor augmentation: a systematic review and meta-analysis of randomized controlled trials
  15. Extremely high levels of alkaline phosphatase and pregnancy outcome: case series and review of the literature
  16. Cervical elastography strain ratio and strain pattern for the prediction of a successful induction of labour
  17. Original Articles – Fetus
  18. CD34 immunostain increases sensitivity of the diagnosis of fetal vascular malperfusion in placentas from ex-utero intrapartum treatment
  19. The ability of various cerebroplacental ratio thresholds to predict adverse neonatal outcomes in term fetuses exhibiting late-onset fetal growth restriction
  20. Obstetric and pediatric growth charts for the detection of late-onset fetal growth restriction and neonatal adverse outcomes
  21. Original Articles – Neonates
  22. Bacterial stability with freezer storage of human milk
  23. Protein and genetic expression of CDKN1C and IGF2 and clinical features related to human umbilical cord length
  24. Short Communication
  25. A considerable asymptomatic proportion and thromboembolism risk of pregnant women with COVID-19 infection in Wuhan, China
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