Maternal obesity influences the endocrine cord blood profile of their offspring
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Carolina Carvalho Mocarzel
und
Asim Kurjak
Abstract
Objective
To compare the endocrine cord blood characteristics of offspring from obese mothers with those of offspring from healthy controls.
Methods
Cross-sectional case control study. Setting: University medical centers. Patient(s): Offspring from obese mothers (n = 41) and healthy controls (n = 31). Intervention(s): Cord blood withdrawal from neonates. Main outcome measure(s): Cord blood total cholesterol (TC), triglycerides (TGs), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), blood glucose (GL) and insulin (Ins).
Result(s)
Fetal GL and TGs were reduced in the offspring of obese women when compared to those in the offspring of the controls. The mean cord blood GL level was 47.8 mg/dL standard deviation (SD 33.1) in the offspring of the obese group vs. 57.9 mg/dL (SD 12.5) in the offspring of the control group, and the mean cord blood TG level was 26.5 (SD 33.6) in the offspring of the obese group vs. 34.6 (SD 12.3) in the offspring of the control group. Maternal obesity was also associated with reduced levels of TC and HDL-C in the pregnant women.
Conclusion
The observed results suggest that GL and TGs in the cord blood of the offspring of obese mothers were significantly lower than those in the offspring of the control group.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2020 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Corner of Academy
- Operative vaginal delivery: a review of four national guidelines
- Mini Review
- Drug exposure during pregnancy and fetal cardiac function – a systematic review
- Original Articles – Obstetrics
- Pregnancy outcomes among women with peptic ulcer disease
- The effect of placental elasticity on intraoperative bleeding in pregnant women with previous cesarean section
- Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes
- Prenatal findings, neonatal symptoms and neurodevelopmental outcome of congenital cytomegalovirus infection in a university hospital in Montreal, Quebec
- Maternal obesity influences the endocrine cord blood profile of their offspring
- Value of cervicovaginal fluid cytokines in prediction of fetal inflammatory response syndrome in pregnancies complicated with preterm premature rupture of membranes (pPROM)
- Reliability of strain elastography using in vivo compression in the assessment of the uterine cervix during pregnancy
- Original Articles – Fetus
- Comparison of strain and dyssynchrony measurements in fetal two-dimensional speckle tracking echocardiography using Philips and TomTec
- Quantitative measurements of celeration times and indexes in the ductus venosus spectral Doppler waveforms in normal fetuses
- Original Articles – Newborns
- Evaluation of cerebral oxygenation and perfusion in small for gestational age neonates and neurodevelopmental outcome at 24–36 months of age
- Measurement of inotropy and systemic oxygen delivery in term, low- and very-low-birth-weight neonates using the Ultrasonic Cardiac Output Monitor (USCOM)
- Short-term neurological improvement in neonates with hypoxic-ischemic encephalopathy predicts neurodevelopmental outcome at 18–24 months
Artikel in diesem Heft
- Frontmatter
- Corner of Academy
- Operative vaginal delivery: a review of four national guidelines
- Mini Review
- Drug exposure during pregnancy and fetal cardiac function – a systematic review
- Original Articles – Obstetrics
- Pregnancy outcomes among women with peptic ulcer disease
- The effect of placental elasticity on intraoperative bleeding in pregnant women with previous cesarean section
- Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes
- Prenatal findings, neonatal symptoms and neurodevelopmental outcome of congenital cytomegalovirus infection in a university hospital in Montreal, Quebec
- Maternal obesity influences the endocrine cord blood profile of their offspring
- Value of cervicovaginal fluid cytokines in prediction of fetal inflammatory response syndrome in pregnancies complicated with preterm premature rupture of membranes (pPROM)
- Reliability of strain elastography using in vivo compression in the assessment of the uterine cervix during pregnancy
- Original Articles – Fetus
- Comparison of strain and dyssynchrony measurements in fetal two-dimensional speckle tracking echocardiography using Philips and TomTec
- Quantitative measurements of celeration times and indexes in the ductus venosus spectral Doppler waveforms in normal fetuses
- Original Articles – Newborns
- Evaluation of cerebral oxygenation and perfusion in small for gestational age neonates and neurodevelopmental outcome at 24–36 months of age
- Measurement of inotropy and systemic oxygen delivery in term, low- and very-low-birth-weight neonates using the Ultrasonic Cardiac Output Monitor (USCOM)
- Short-term neurological improvement in neonates with hypoxic-ischemic encephalopathy predicts neurodevelopmental outcome at 18–24 months
