Value of cervicovaginal fluid cytokines in prediction of fetal inflammatory response syndrome in pregnancies complicated with preterm premature rupture of membranes (pPROM)
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Mateusz Mikołajczyk
,
Przemysław Wirstlein
Abstract
Background
Preterm premature rupture of membranes (pPROM) is associated with a high risk of prematurity and complications of fetal inflammatory response syndrome (FIRS). The aim of the study is to determine any correlations between the concentration of selected cytokines contained in the cervicovaginal secretion eluates and in the umbilical cord plasma in patients with pPROM and to find the noninvasive markers of FIRS in order to pinpoint the optimal time of the delivery.
Methods
The study included 80 patients with pPROM between the 24th and 34th week of gestation. The cervicovaginal fluid and umbilical cord blood were collected. Interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 19 (IL-19) and tumor necrosis factor-α (TNF-α) concentrations were measured in both materials. For the statistical analysis, SigmaStat3.5 software was used.
Results
There was no direct association in levels of IL-6, TNF-α, IL-10 and IL-19 between the cord blood and cervicovaginal secretions within the studied group. The cut-off point of IL-6 of 26.8 pg/mL in the vaginal fluid had high sensitivity and specificity in order to discriminate between newborns with and without FIRS (81.08%; 76.74%).
Conclusion
Further studies are needed on a larger group of participants to demonstrate that an elevated concentration of IL-6 above 26.8 pg/mL in the cervicovaginal secretion eluate is an indirect noninvasive marker of FIRS.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: The work was funded by the Statutory Research Fund For Division of Reproduction No: 502-01-01110142-00304.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/jpm-2019-0280).
©2020 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Corner of Academy
- Operative vaginal delivery: a review of four national guidelines
- Mini Review
- Drug exposure during pregnancy and fetal cardiac function – a systematic review
- Original Articles – Obstetrics
- Pregnancy outcomes among women with peptic ulcer disease
- The effect of placental elasticity on intraoperative bleeding in pregnant women with previous cesarean section
- Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes
- Prenatal findings, neonatal symptoms and neurodevelopmental outcome of congenital cytomegalovirus infection in a university hospital in Montreal, Quebec
- Maternal obesity influences the endocrine cord blood profile of their offspring
- Value of cervicovaginal fluid cytokines in prediction of fetal inflammatory response syndrome in pregnancies complicated with preterm premature rupture of membranes (pPROM)
- Reliability of strain elastography using in vivo compression in the assessment of the uterine cervix during pregnancy
- Original Articles – Fetus
- Comparison of strain and dyssynchrony measurements in fetal two-dimensional speckle tracking echocardiography using Philips and TomTec
- Quantitative measurements of celeration times and indexes in the ductus venosus spectral Doppler waveforms in normal fetuses
- Original Articles – Newborns
- Evaluation of cerebral oxygenation and perfusion in small for gestational age neonates and neurodevelopmental outcome at 24–36 months of age
- Measurement of inotropy and systemic oxygen delivery in term, low- and very-low-birth-weight neonates using the Ultrasonic Cardiac Output Monitor (USCOM)
- Short-term neurological improvement in neonates with hypoxic-ischemic encephalopathy predicts neurodevelopmental outcome at 18–24 months
Articles in the same Issue
- Frontmatter
- Corner of Academy
- Operative vaginal delivery: a review of four national guidelines
- Mini Review
- Drug exposure during pregnancy and fetal cardiac function – a systematic review
- Original Articles – Obstetrics
- Pregnancy outcomes among women with peptic ulcer disease
- The effect of placental elasticity on intraoperative bleeding in pregnant women with previous cesarean section
- Cellular immune responses in amniotic fluid of women with preterm prelabor rupture of membranes
- Prenatal findings, neonatal symptoms and neurodevelopmental outcome of congenital cytomegalovirus infection in a university hospital in Montreal, Quebec
- Maternal obesity influences the endocrine cord blood profile of their offspring
- Value of cervicovaginal fluid cytokines in prediction of fetal inflammatory response syndrome in pregnancies complicated with preterm premature rupture of membranes (pPROM)
- Reliability of strain elastography using in vivo compression in the assessment of the uterine cervix during pregnancy
- Original Articles – Fetus
- Comparison of strain and dyssynchrony measurements in fetal two-dimensional speckle tracking echocardiography using Philips and TomTec
- Quantitative measurements of celeration times and indexes in the ductus venosus spectral Doppler waveforms in normal fetuses
- Original Articles – Newborns
- Evaluation of cerebral oxygenation and perfusion in small for gestational age neonates and neurodevelopmental outcome at 24–36 months of age
- Measurement of inotropy and systemic oxygen delivery in term, low- and very-low-birth-weight neonates using the Ultrasonic Cardiac Output Monitor (USCOM)
- Short-term neurological improvement in neonates with hypoxic-ischemic encephalopathy predicts neurodevelopmental outcome at 18–24 months
