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Multi-center results on the clinical use of KANET

  • Asim Kurjak , Lara Spalldi Barišić EMAIL logo , Milan Stanojević , Panagiotis Antsaklis , Sonal Panchal , Ulrich Honemeyer , Raul Moreira Neto , Suada Tinjić , Radu Vladareanu , Sertaç Esin , Dorota Bomba-Opon , Edin Međedović und Toshyuki Hata
Veröffentlicht/Copyright: 2. November 2019

Abstract

An extensive review of the literature on the diagnostic and clinical accuracy of Kurjak’s antenatal neurodevelopmental test (KANET) and the summarized results of the multi-center study involving 10 centers revealed that four-dimensional ultrasonography (4D US) has become a powerful tool and KANET a valuable test that empowers the clinicians worldwide to evaluate the fetal behavior in a systematic way and contribute to the detection of fetuses that might be at high risk for neurological impairments and in particular cerebral palsy (CP). After 10 years of clinical use, many published papers and multi-center studies, hundreds of trained physicians and numerous tests performed all over the world, KANET has proven its value and has been showing encouraging results so far. The aim of this paper is to show the results from the studies done so far and to reveal the clinical value of the KANET. We expect that data from the larger ongoing collaborative study, the short- and long-term postnatal follow-up will continue to improve our knowledge. Ultimately, we all strive to prevent the CP disorders, autism spectrum disorder (ASD) and other neurological impairments and we are convinced that KANET might be helpful in the realization of this important aim.


Corresponding author: Lara Spalldi Barišić, MD, MSc, PhD Candidate, University Sarajevo School of Science and Technology, Sarajevo, Bosnia and Herzegovina; and Specialist, Department of Obstetrics and Gynecology, Private Clinic Veritas, Zagreb, Croatia

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

References

1. Kurjak A, Stanojević M, Andonotopo W, Scazzocchio-Duenas E, Azumendi G, Carrera JM. Fetal behavior assessed in all three trimesters of normal pregnancy by four-dimensional ultrasonography. Croat Med J 2005;46:772–80.Suche in Google Scholar

2. Kurjak A, Stanojević M, Andonotopo W, Salihagic-Kadic A, Carrera JM, Azumendi G. Behavioral pattern continuity from prenatal to postnatal life – a study by four-dimensional (4D) ultrasonography. J Perinat Med 2004;32:346–53.10.1515/JPM.2004.065Suche in Google Scholar PubMed

3. Ahmed B, Kurjak A, Andonotopo W, Khenyab N, Saleh N, Al Mansoori Z. Fetal behavioral and structural abnormalities in high risk fetuses assessed by 4D sonography. Ultrasound Rev Obstet Gynecol 2005;5:1–13.10.3109/14722240500386867Suche in Google Scholar

4. Andonotopo W, Kurjak A, Kosuta MI. Behavior of an anencephalic fetus studied by 4D sonography. J Matern Fetal Neonatal Med 2005;17:165–8.10.1080/jmf.17.2.165.168Suche in Google Scholar

5. Kurjak A, Andonotopo W, Hafner T, Salihagic Kadic A, StanojevicM, Azumendi G, et al. Normal standards for fetal neurobehavioral developments – longitudinal quantification by four-dimensional sonography. J Perinat Med 2006;34: 56–65.10.1515/JPM.2006.007Suche in Google Scholar PubMed

6. Andonotopo W, Kurjak A. The assessment of fetal behavior of growth restricted fetuses by 4D sonography. J Perinat Med 2006;34:471–8.10.1515/JPM.2006.092Suche in Google Scholar PubMed

7. Kurjak A, Azumendi G, Andonotopo W, Salihagic-Kadic A. Three- and four-dimensional ultrasonography for the structural and functional evaluation of the fetal face. Am J Obstet Gynecol 2007;196:16–28.10.1016/j.ajog.2006.06.090Suche in Google Scholar PubMed

8. Kurjak A, Misković B, Stanojević M, Amiel-Tison C, Ahmed B, Azumendi G, et al. New scoring system for fetal neurobehavior assessed by three- and four-dimensional sonography. J Perinat Med 2008;36:73–81.10.1515/JPM.2008.007Suche in Google Scholar PubMed

9. Kurjak A, Abo-Yaqoub S, Stanojevic M, Yigiter AB, Vasilj O, Lebit D, et al. The potential of 4D sonography in the assessment of fetal neurobehavior – multicentric study in high-risk pregnancies. J Perinat Med 2010;38:77–82.10.1515/jpm.2010.012Suche in Google Scholar PubMed

10. MacLennan AH, Thompson SC, Gecz J. Cerebral palsy: causes, pathways, and the role of genetic variants. Australian Collaborative Cerebral Palsy Research Group. Am J Obstet Gynecol 2015;213:779–88.10.1016/j.ajog.2015.05.034Suche in Google Scholar PubMed

11. Kanenishi K, Hanaoka U, Noguchi J, Marumo G, Hata T. 4D ultrasound evaluation of fetal facial expressions during the latter stages of the second trimester. Int J Gynaecol Obstet 2013;121:257–60.10.1016/j.ijgo.2013.01.018Suche in Google Scholar PubMed

12. Stanojević M, Talic A, Miskovic B, Vasilj O, Shaddad AN, Ahmed B, et al. An attempt to standardize Kurjak’s antenatal neurodevelopmental test: Osaka consensus statement. Donald School J Ultrasound Obstet Gynecol 2011;5:317–29.10.5005/jp-journals-10009-1209Suche in Google Scholar

13. Stanojevic M, Antsaklis P, Salihadic-Kadic A, Predojevic M, Vladareanu R, Vladareanu S, et al. Is Kurjak antenatal neurodevelopmental test ready for routine clinical application? Bucharest Consensus Statement. Donald School J Ultrasound Obstet Gynecol 2015;3:260–5.10.5005/jp-journals-10009-1412Suche in Google Scholar

14. Neto RM. KANET in Brazil: first experience. Donald School J Ultrasound Obstet Gynecol 2015;9:15.Suche in Google Scholar

15. Kurjak A, Antsaklis P, Stanojevic M. Fetal neurology: past, present and future. Donald School J Ultrasound Obstet Gynecol 2015;9:6–29.10.5005/jp-journals-10009-1385Suche in Google Scholar

16. Luetic AT. First experience in clinical application of KANET. Donald School J Ultrasound Obstet Gynecol 2015;9:96–9.10.5005/jp-journals-10009-1395Suche in Google Scholar

17. Vasilj O. Is in utero fetal neurological assessment comparable to postnatal neurological assessment? Donald School J Ultrasound Obstet Gynecol 2015;9:91–5.10.5005/jp-journals-10009-1394Suche in Google Scholar

18. Stanojevic M. Antenatal and postnatal assessment of neurobehavior: which one should be used? Donald School J Ultrasound Obstet Gynecol 2015;9:67–74.10.5005/jp-journals-10009-1391Suche in Google Scholar

19. Lebit FD, Vladreanu R. The role of 4D ultrasound in the assessment of fetal behavior. Maedica (Buchar) 2011;6:120–7.Suche in Google Scholar

20. Tomasovic S, Predojevic M. Four-dimensional ultrasound medical devices for recent advances on the etiology of cerebral palsy. Acta Inform Med 2011;19:228–34.10.5455/aim.2011.19.228-234Suche in Google Scholar PubMed PubMed Central

21. Vladareanu R, Lebit D, Constantinescu S. Ultrasound assessment of fetal neurobehavior in high-risk pregnancies. Donald School J Ultrasound Obstet Gynecol 2012;6:132–47.10.5005/jp-journals-10009-1235Suche in Google Scholar

22. Honemeyer U, Talic A, Therwat A, Paulose I, Patidar R. The clinical value of KANET test in studying fetal neurobehavior in normal and at-risk pregnancies. J Perinat Med 2013;41:187–97.10.1515/jpm-2011-0251Suche in Google Scholar PubMed

23. Kuno A, Akiyama M, Yamashiro C, Tanaka H, Yanagihara T, Hata T. Three-dimensional sonographic assessment of fetal behaviour in the early second trimester of pregnancy. J Ultrasound Med 2001;20:1271–5.10.7863/jum.2001.20.12.1271Suche in Google Scholar PubMed

24. Salihagic Kadic A. Fetal neurology: the role of fetal stress. Donald School J Ultrasound Obstet Gynecol 2015;9:30–9.10.5005/jp-journals-10009-1386Suche in Google Scholar

25. Hata T, Kanenishi J, Hanoka U, Uematsu R, Marumo G, Tanaka H. HDlive study of fetal development and behavior. Donald School J Ultrasound Obstet Gynecol 2014;8:250–65.10.5005/jp-journals-10009-1363Suche in Google Scholar

26. Reynoso C, Crespo-Eguílaz N, Alcázar JL, Narbona J. Motor behavior of human fetuses during the second trimester of gestation: a longitudinal ultrasound study. An Pediatr (Barc) 2015;82:183–91.10.1016/j.anpedi.2014.05.011Suche in Google Scholar

27. Predojević M, Talić A, Stanojević M, Kurjak A, Salihagić Kadić A. Assessment of motoric and hemodynamic parameters in growth restricted fetuses – case study. J Matern Fetal Neonatal Med 2014;27:247–51.10.3109/14767058.2013.807241Suche in Google Scholar

28. Kurjak A, Talic A, Stanojevic M, Honemeyer U, Serra B, Prats P, et al. The study of fetal neurobehavior in twins in all three trimesters of pregnancy. J Matern Fetal Neonatal Med 2013;26: 1186–95.10.3109/14767058.2013.773306Suche in Google Scholar

29. Kurjak A, Talic A, Honemeyer U, Stanojevic M, Zalud I. Comparison between antenatal neurodevelopmental test and fetal Doppler in the assessment of fetal wellbeing. J Perinat Med 2013;41:107–14.10.1515/jpm-2012-0018Suche in Google Scholar

30. Athanasiadis AP, Mikos T, Tambakoudis GP, Theodoridis TD, Papastergiou M, Assimakopoulos E, et al. Neurodevelopmental fetal assessment using KANET scoring system in low and high risk pregnancies. J Matern Fetal Neonatal Med 2013;26:363–8.10.3109/14767058.2012.695824Suche in Google Scholar

31. Guimarães Filho HA, Araujo Júnior E, Mello Júnior CF, Nardozza LM, Moron AF. Assessment of fetal behavior using four-dimensional ultrasonography: current knowledge and perspectives. Rev Assoc Med Bras 2013;59:507–13.10.1016/S2255-4823(13)70510-1Suche in Google Scholar

32. Kurjak A, Stanojević M, Predojević M, Laušin I, Salihagić Kadić A. Neurobehavior in fetal life. Semin Fetal Neonatal Med 2012;17:319–23.10.1016/j.siny.2012.06.005Suche in Google Scholar PubMed

33. Stanojevic M, Zaputovic S, Bosnjak AP. Continuity between fetal and neonatal neurobehavior. Semin Fetal Neonatal Med 2012;17:324–9.10.1016/j.siny.2012.06.006Suche in Google Scholar PubMed

34. Kurjak A, Predojevic M, Stanojevic M, Kadic AS, Miskovic B, Badreldeen A, et al. Intrauterine growth restriction and cerebral palsy. Acta Inform Med 2012;18:64–82.10.5455/aim.2010.18.64-82Suche in Google Scholar PubMed PubMed Central

35. Talic A, Kurjak A, Stanojevic M, Honemeyer U, Badreldeen A, DiRenzo GC. The assessment of fetal brain function in fetuses with ventrikulomegaly: the role of the KANET test. J Matern Fetal Neonatal Med 2012;25:1267–72.10.3109/14767058.2011.634463Suche in Google Scholar PubMed

36. Talic A, Kurjak A, Ahmed B, Stanojevic M, Predojevic M, Kadic AS, et al. The potential of 4D sonography in the assessment of fetal behavior in high-risk pregnancies. J Matern Fetal Neonatal Med 2011;24:948–54.10.3109/14767058.2010.534830Suche in Google Scholar PubMed

37. Kurjak A, Antsaklis P, Stanojević M, Vladareanu R, Vladareanu S, Moreira Neto R, et al. Multicentric studies of the fetal neurobehavior by KANET. J Perinat Med 2017;45:717–27.10.1515/jpm-2016-0409Suche in Google Scholar PubMed

38. Kurjak A, Antsaklis P. Four-dimensional ultrasound in functional studies of the fetus. In: Merz E, Kurjak A, editors. Donald School Textbook Current Status of Clinical Use of 3D/ 4D Ultrasound in Obstetrics and Gynecology. New Delhi: Jaypee Brothers Med Publ 2019. p.199–209.Suche in Google Scholar

39. Miskovic B, Vasilj O, Stanojevic M, Ivanković D, Kerner M, Tikvica A. The comparison of fetal behavior in high risk and normal pregnancies assessed by four dimensional ultrasound. J Matern Fetal Neonatal Med 2010;23:1461–7.10.3109/14767051003678200Suche in Google Scholar PubMed

40. Honemeyer U, Kurjak A. The use of KANET test to assess fetal CNS function. First 100 cases. 10th World Congress of Perinatal Medicine 8–11 November 2011. Uruguay: Poster Presentation P. 209.Suche in Google Scholar

41. Abo-Yaqoub S, Kurjak A, Mohammed AB, Shadad A, Abdel-Maaboud M. The role of 4-D ultrasonography in prenatal assessment of fetal neurobehaviour and prediction of neurological outcome. J Matern Fetal Neonatal Med 2012;25:231–6.10.3109/14767058.2011.568552Suche in Google Scholar PubMed

42. Hanaoka U, Hata T, Kanenishi K, Mostafa AboEllail MA, Uematsu R, Konishi Y, et al. Does ethnicity have an effect on fetal behavior? A comparison of Asian and Caucasian populations. J Perinat Med 2016;44:217–21.10.1515/jpm-2015-0036Suche in Google Scholar PubMed

43. Hata T, Hanaoka U, Mostafa AboEllail MA, Uematsu R, Noguchi J, Kusaka T, et al. Is there a sex difference in fetal behavior? A comparison of the KANET test between male and female fetuses. J Perinat Med 2016;44:585–8.10.1515/jpm-2015-0387Suche in Google Scholar PubMed

44. Antsaklis P, Porovic S, Daskalakis G, Kurjak A. 4D assessment of fetal brain function in diabetic patients. J Perinat Med 2017;45:711–5.10.1515/jpm-2016-0394Suche in Google Scholar PubMed

45. Hata T, Kanenishi K, Mori N, AboEllail MAM, Hanaoka U, Koyano K, et al. Prediction of postnatal developmental disabilities using the antenatal fetal neurodevelopmental test: KANET assessment. J Perinat Med 2018;47:77–81.10.1515/jpm-2018-0169Suche in Google Scholar PubMed

46. Tan KH, Smyth RMD, Wei X. Fetal vibroacoustic stimulation for facilitation of tests of fetal wellbeing. Cochrane Database Syst Rev 2013; Art. No.: CD002963. DOI: 10.1002/14651858.CD002963.pub2.Suche in Google Scholar PubMed

47. Spalldi Barišić L, Kurjak A, Kimata Pooh R. Three-dimensional sonography in fetal syndromes. In: Merz E, Kurjak A, editors. Donald School Textbook Current Status of Clinical Use of 3D/4D Ultrasound in Obstetrics and Gynecology. New Delhi: Jaypee Brothers Med Publ 2019. p. 301–20.Suche in Google Scholar

48. O’Callaghan ME, MacLennan AH, Gibson CS, McMichael GL, Haan EA, Broadbent JL, et al. Australian collaborative cerebral palsy research group. Epidemiologic associations with cerebral palsy. Obstet Gynecol 2011;118:576–82.10.1097/AOG.0b013e31822ad2dcSuche in Google Scholar PubMed

49. Kelly CJ, Makropoulos A, Cordero-Grande L, Hutter J, Price A, Hughes E, et al. Impaired development of the cerebral cortex in infants with congenital heart disease is correlated to reduced cerebral oxygen delivery. Nat Sci Rep 2017;7:15088.10.1038/s41598-017-14939-zSuche in Google Scholar PubMed PubMed Central

50. Ronan L, Fletcher PC. From genes to folds: a review of cortical gyrification theory. Brain Struct Funct 2015;220:2475–83.10.1007/s00429-014-0961-zSuche in Google Scholar PubMed PubMed Central

51. Armstrong E, Schleicher A, Omran H, Curtis M, Zilles K. The ontogeny of human gyrification. Cereb Cortex 1995;5:56–63.10.1093/cercor/5.1.56Suche in Google Scholar PubMed

52. Rudra A, Belmonte MK, Soni PK, Banerjee S, Mukerji S, Chakrabarti B. Prevalence of autism spectrum disorder and autistic symptoms in a school-based cohort of children in Kolkata, India. Autism Res 2017;10:1597–605.10.1002/aur.1812Suche in Google Scholar PubMed PubMed Central

53. Diallo FB, Fombonne E, Kisely S, Rochette L, Vasiliadis HM, Vanasse A, et al. Prevalence and correlates of autism spectrum disorders in Quebec. Can J Psychiatry 2018;63:231–9.10.1177/0706743717737031Suche in Google Scholar PubMed PubMed Central

54. Raina SK, Chander V, Bhardwaj AK, Kumar D, Sharma S, Kashyap V, et al. Prevalence of autism spectrum disorder among rural, urban, and tribal children. J Neurosci Rural Pract 2017;8:368–74.10.4103/jnrp.jnrp_329_16Suche in Google Scholar PubMed PubMed Central

55. Zablotsky B, Black LI, Maenner MJ, Schieve LA, BlumbergSJ. Estimated prevalence of autism and other developmental disabilities following questionnaire changes in the 2014 national health interview survey. Nat Health Stat Rep 2015;13:1–20.Suche in Google Scholar

56. Delobel-Ayoub M, Klapouszczak D, van Bakel MME, Horridge K, Sigurdardottir S, Himmelmann K, et al. Prevalence and characteristics of autism spectrum disorders in children with cerebral palsy. Dev Med Child Neurol 2017;59:738–42.10.1111/dmcn.13436Suche in Google Scholar PubMed

57. Nardone S, Elliott E. The interaction between the immune system and epigenetics in the etiology of autism spectrum disorders. Front Neurosci 2016;10:329.10.3389/fnins.2016.00329Suche in Google Scholar PubMed PubMed Central

58. Haak P, Lenski M, Hidecker MJ, Li M, Paneth N. Cerebral palsy and aging. Dev Med Child Neurol 2009;51:16–23.10.1111/j.1469-8749.2009.03428.xSuche in Google Scholar PubMed PubMed Central

59. Robinson EB, St Pourcain B, Anttila V, Kosmicki JA, Bulik-Sullivan B, Grove J, et al. Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. Nat Genet 2016;48:552–5.10.1038/ng.3529Suche in Google Scholar PubMed PubMed Central

60. Kunze A, Achilles A, Keiner S, Witte OW, Redecker C. Two distinct populations of doublecortin-positive cells in the perilesional zone of cortical infarcts. BMC Neurosci 2015;16:20.10.1186/s12868-015-0160-8Suche in Google Scholar PubMed PubMed Central

61. Kunze A, Grass S, Witte OW, Yamaguchi M, Kempermann G, Redecker C. Proliferative response of distinct hippocampal progenitor cell populations after cortical infarcts in the adult brain. Neurobiol Dis 2006;21:324–32.10.1016/j.nbd.2005.07.013Suche in Google Scholar PubMed

62. Barker DJ. The developmental origins of chronic adult disease. Acta Paediatr Suppl 2004;93:26–33.10.1111/j.1651-2227.2004.tb00236.xSuche in Google Scholar PubMed

Received: 2019-07-25
Accepted: 2019-09-21
Published Online: 2019-11-02
Published in Print: 2019-11-26

©2019 Walter de Gruyter GmbH, Berlin/Boston

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