Low dose aspirin for preventing fetal growth restriction: a randomised trial
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Anca-Daniela Stanescu
und
Liana Ples
Abstract
The purpose of this study was to investigate when in pregnancy to stop the administration of low dose aspirin (150 mg/daily) so as to prevent fetal growth restriction (FGR) A randomised, placebo-controlled study was designed. The patients were all screened positive using the Fetal Medicine Foundation (FMF) early pregnancy screening test for preeclampsia (PE) and FGR prediction. One hundred and fifty patients were enrolled and divided equally into three groups: A – the controls who received placebo treatment; B – those who received aspirin till 32 weeks of gestation and C – those who received aspirin till 36 weeks of gestation. The mean gestational age at enrollment was similar for all the groups (12.4 weeks). The growth curves, fetal and maternal Doppler measurements and amniotic fluid index (AFI) were monitored every 4 weeks. Also, the outcome of the pregnancy was noted and all the results were compared between the groups. FGR was defined as a fetal weight below the 10th centile for gestational age. In group C, there were less cases of FGR compared with the other groups: 6% vs. 10% in group B vs. 24% in controls. Also, there was a significant birth weight improvement in this group with a median of 3180 g compared with 2950 g in group B and 2760 g in group A (P=0.01). The gestational age at delivery was similar in all the groups (39 weeks in group C/39.2 weeks in group B/38.6 weeks in group A). In conclusion, low dose aspirin improves the outcome in the selected population and should be offered for prevention of FGR from 12 to 36 weeks.
Author’s statement
Conflict of interest: Authors state no conflict of interest.
Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.
Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Editorial
- Antenatal and prepregnancy care – prevention of perinatal morbidity and mortality
- Review article
- Fetal interventional procedures and surgeries: a practical approach
- Opinion paper
- Inverted pyramid of prenatal care – is it enough? Should it be – extended inverted pyramid of prenatal care?
- Research articles
- Expectant management in di-chorionic pregnancies complicated by discordant anomalous twin
- Pregnancy outcomes among patients with recurrent pregnancy loss and uterine anatomic abnormalities
- Early postnatal echocardiographic assessment of pulmonary blood flow in newborns with congenital diaphragmatic hernia
- Sonographic prediction of small and large for gestational age in breech-presenting fetuses
- Comparison of fetal weight distribution improved by paternal height by Spanish standard versus Intergrowth 21st standard
- Can early ultrasonography explain the lower miscarriage rates in twin as compared to singleton pregnancies following assisted reproduction?
- Pregnancy outcomes among patients with recurrent pregnancy loss and chromosomal aberration (CA) without PGD
- Regular research articles
- Induction of labor in twin gestation: can we predict success?
- Low dose aspirin for preventing fetal growth restriction: a randomised trial
- Mid-pregnancy cervical length as a risk factor for cesarean section in women with twin pregnancies
- Efficacy of three different regimens in recovery of bowel function following elective cesarean section: a randomized trial
- Obstetrical, maternal and neonatal outcomes in pregnancies affected by muscular dystrophy
- Fetal brain development in diabetic pregnancies and normal controls
- Body composition in preterm infants with intrauterine growth restriction: a cohort study
- Commentary
- Professionally responsible management of gynecologic cancer in pregnancy when clinical resources are unavoidably limited
- Letters to the Editor
- Erroneous conclusion due to mis-calculation of data: reply to Rai SE, Sidhu AK, Krishnan RJ. Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis. J Perinat Med 2017
- Reply to: Letter to the Editor by Stritzke A and Shah PS. Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis
- Congenital Zika syndrome in non-endemic regions
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Artikel in diesem Heft
- Frontmatter
- Editorial
- Antenatal and prepregnancy care – prevention of perinatal morbidity and mortality
- Review article
- Fetal interventional procedures and surgeries: a practical approach
- Opinion paper
- Inverted pyramid of prenatal care – is it enough? Should it be – extended inverted pyramid of prenatal care?
- Research articles
- Expectant management in di-chorionic pregnancies complicated by discordant anomalous twin
- Pregnancy outcomes among patients with recurrent pregnancy loss and uterine anatomic abnormalities
- Early postnatal echocardiographic assessment of pulmonary blood flow in newborns with congenital diaphragmatic hernia
- Sonographic prediction of small and large for gestational age in breech-presenting fetuses
- Comparison of fetal weight distribution improved by paternal height by Spanish standard versus Intergrowth 21st standard
- Can early ultrasonography explain the lower miscarriage rates in twin as compared to singleton pregnancies following assisted reproduction?
- Pregnancy outcomes among patients with recurrent pregnancy loss and chromosomal aberration (CA) without PGD
- Regular research articles
- Induction of labor in twin gestation: can we predict success?
- Low dose aspirin for preventing fetal growth restriction: a randomised trial
- Mid-pregnancy cervical length as a risk factor for cesarean section in women with twin pregnancies
- Efficacy of three different regimens in recovery of bowel function following elective cesarean section: a randomized trial
- Obstetrical, maternal and neonatal outcomes in pregnancies affected by muscular dystrophy
- Fetal brain development in diabetic pregnancies and normal controls
- Body composition in preterm infants with intrauterine growth restriction: a cohort study
- Commentary
- Professionally responsible management of gynecologic cancer in pregnancy when clinical resources are unavoidably limited
- Letters to the Editor
- Erroneous conclusion due to mis-calculation of data: reply to Rai SE, Sidhu AK, Krishnan RJ. Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis. J Perinat Med 2017
- Reply to: Letter to the Editor by Stritzke A and Shah PS. Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis
- Congenital Zika syndrome in non-endemic regions
- Reply to: Congenital Zika syndrome in non-endemic regions: A neuroimaging pattern-based approach
