Relationship between various maternal conditions and lactic acid dehydrogenase activity in umbilical cord blood at birth
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Evangelos Patavoukas
Abstract
Background:
Lactic acid dehydrogenase (LDH) is a valuable marker for some of the most important diseases in newborns and the plasma LDH activity in newborns correlates well with conditions such as asphyxia. If LDH should be considered as a useful tool also in obstetric care, key factors associated with maternal health before and during pregnancy which could affect umbilical cord LDH activity need to be known. The aims of this study were to explore relationships between selected maternal conditions and arterial lactic acid dehydrogenase activity (aLDH) in umbilical cord blood at delivery.
Methods:
A prospective observational study was conducted at Sodersjukhuset, Stockholm, Sweden. Included in the study were 1247 deliveries, and cord blood samples from each were analyzed for aLDH. Background, delivery and neonatal data were collected from the medical records.
Results:
Higher median values of aLDH were found (P=0.001) among women with chronic disorders not related to pregnancy but there was no increased frequency of high aLDH levels (>612 μ/L, P=0.30). No difference in aLDH was identified between infants born to women with pregnancy-related disorders compared with healthy women, neither in median values, nor in high values (>612 μ/L, P=0.95).
Conclusion:
Newborn infants born to women with non-pregnancy-related chronic disorders had a somewhat higher median value of aLDH in cord blood at delivery. The influence of common maternal conditions and diseases on umbilical cord arterial LDH levels is small compared to the increase reported in fetal distress and several other critical conditions in the newborn.
Acknowledgments
We acknowledge all the women who consented to participate in this trial and the large number of midwives and assistant nurses in the delivery ward of Sodersjukhuset.
Author’s statement
Conflict of interest: BW has share options of a start-up medical technology company (www.calmark.se) that develops in-vitro diagnostic devices for use e.g. at the point-of-care for analysis of LDH in the neonatal period and could therefore get future economic benefits from the results of the present study. The other authors declare that they have no conflicts of interest.
Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.
Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.
Funding: The project was funded by the Signhild Engqvist Foundation, Sweden.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Editorial
- A tribute to Ingrid Gruenberg, Managing Editor of the Journal of Perinatal Medicine and Case Reports in Perinatal Medicine
- Highlight: Intrapartum Care
- Editorial
- Intrapartum care
- Highlight articles
- Trends in characteristics of women choosing contraindicated home births
- Impact factors on fetal descent rates in the active phase of labor: a retrospective cohort study
- Fetal cardiac time intervals in healthy pregnancies – an observational study by fetal ECG (Monica Healthcare System)
- Hypercoiling of the umbilical cord in uncomplicated singleton pregnancies
- Validation of a new algorithm for the short-term variation of the fetal heart rate: an antepartum prospective study
- Relationship between various maternal conditions and lactic acid dehydrogenase activity in umbilical cord blood at birth
- The frequency and type of placental histologic lesions in term pregnancies with normal outcome
- Review article
- Clinical study of fetal neurobehavior by the KANET test
- Regular articles
- Maternal demographic factors associated with emergency caesarean section for non-reassuring foetal status
- Early usage of Bakri postpartum balloon in the management of postpartum hemorrhage: a large prospective, observational multicenter clinical study in South China
- Efficacy of inhaled nitric oxide in neonates with hypoxic respiratory failure and pulmonary hypertension: the Japanese experience
- Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis
- Transfusion-associated necrotizing enterocolitis in preterm infants: an updated meta-analysis of observational data
- Commentary
- Watch out for congenital Zika syndrome in non-endemic regions
- Letters to the Editor
- Cervical pessary combined with vaginal progesterone for the prevention of spontaneous preterm birth: is the evidence sufficient?
- Reply to: Cervical pessary combined with vaginal progesterone for the prevention of spontaneous preterm birth: is evidence sufficient?
- Obituary
- Klaus Riegel (1926–2018)
Articles in the same Issue
- Frontmatter
- Editorial
- A tribute to Ingrid Gruenberg, Managing Editor of the Journal of Perinatal Medicine and Case Reports in Perinatal Medicine
- Highlight: Intrapartum Care
- Editorial
- Intrapartum care
- Highlight articles
- Trends in characteristics of women choosing contraindicated home births
- Impact factors on fetal descent rates in the active phase of labor: a retrospective cohort study
- Fetal cardiac time intervals in healthy pregnancies – an observational study by fetal ECG (Monica Healthcare System)
- Hypercoiling of the umbilical cord in uncomplicated singleton pregnancies
- Validation of a new algorithm for the short-term variation of the fetal heart rate: an antepartum prospective study
- Relationship between various maternal conditions and lactic acid dehydrogenase activity in umbilical cord blood at birth
- The frequency and type of placental histologic lesions in term pregnancies with normal outcome
- Review article
- Clinical study of fetal neurobehavior by the KANET test
- Regular articles
- Maternal demographic factors associated with emergency caesarean section for non-reassuring foetal status
- Early usage of Bakri postpartum balloon in the management of postpartum hemorrhage: a large prospective, observational multicenter clinical study in South China
- Efficacy of inhaled nitric oxide in neonates with hypoxic respiratory failure and pulmonary hypertension: the Japanese experience
- Transfusion-associated necrotizing enterocolitis re-evaluated: a systematic review and meta-analysis
- Transfusion-associated necrotizing enterocolitis in preterm infants: an updated meta-analysis of observational data
- Commentary
- Watch out for congenital Zika syndrome in non-endemic regions
- Letters to the Editor
- Cervical pessary combined with vaginal progesterone for the prevention of spontaneous preterm birth: is the evidence sufficient?
- Reply to: Cervical pessary combined with vaginal progesterone for the prevention of spontaneous preterm birth: is evidence sufficient?
- Obituary
- Klaus Riegel (1926–2018)
