Abstract:
Fetal cardiac tumors are rare and usually benign. While echocardiography is a reliable technique for diagnosing fetal cardiac tumors, their definitive diagnosis relies on pathological examination. The strategies used to manage fetal cardiac tumors are challenging. A good clinical result is their complete regression during pregnancy or shortly after birth, as often occurs with cardiac rhabdomyomas. Moreover, the fetal prognosis depends on the nature of the tumors, namely, their location, size, number and associated complications. The active treatment options for symptomatic fetuses depend on the fetal status and may include fetal open surgery, postnatal tumor resection with or without the bridge of intrauterine pericardiocentesis, and thoracoamniotic shunting. The ex utero intrapartum treatment procedure provides an alternative technique for performing fetal open surgery and has shown promising preliminary results in selected cases, but is invasive for both the mother and fetus.
Author’s Statement
Conflict of interest: Authors state no conflict of interest.
Material and methods: Informed consent: Informed consent has been obtained from all individuals included in this study.
Ethical approval: The research related to human subject use has complied with all the relevant national regulations, and institutional policies, and is in accordance with the tenets of the Helsinki Declaration, and has been approved by the authors’ institutional review board or equivalent committee.
References
[1] Groves AM, Fagg NL, Cook AC, Allan LD. Cardiac tumours in intrauterine life. Arch Dis Child. 1992;67:1189–92.10.1136/adc.67.10_Spec_No.1189Search in Google Scholar
[2] Holley DG, Martin GR, Brenner JI, Fyfe DA, Huhta JC, Kleinman CS, et al. Diagnosis and management of fetal cardiac tumors: a multicenter experience and review of published reports. J Am Coll Cardiol. 1995;26:516–20.10.1016/0735-1097(95)80031-BSearch in Google Scholar
[3] Gutiérrez-Larraya Aguado F, Galindo Izquierdo A, Olaizola Llodio JI, Sotelo Rodríguez MT, Merino Batres G, Velasco Bayón JM, et al. Tumores cardíacos fetales. Rev Esp Cardiol. 1997;50:187–91. [Article in Spanish]10.1016/S0300-8932(97)73202-0Search in Google Scholar
[4] Savío Benavides A, Oliva Rodríguez J, García Morejón C, García Guevara C, Arencibia Faire J, Ponce Bittar J. Diagnóstico ecocardiográfico de los tumores primarios del corazón en el feto. Rev Cubana Pediatr. 2009;81:1–9. [Article in Spanish]Search in Google Scholar
[5] Uzun O, Wilson DG, Vujanic GM, Parsons JM, De Giovanni JV. Cardiac tumours in children. Orphanet J Rare Dis. 2007;2:11.10.1186/1750-1172-2-11Search in Google Scholar
[6] Bruce CJ. Cardiac tumours: diagnosis and management. Heart 2011;97:151–60.10.1136/hrt.2009.186320Search in Google Scholar
[7] Yinon Y, Chitayat D, Blaser S, Seed M, Amsalem H, Yoo SJ, et al. Fetal cardiac tumors: a single-center experience of 40 cases. Prenat Diagn. 2010;30:941–9.10.1002/pd.2590Search in Google Scholar
[8] Isaacs H Jr. Fetal and neonatal cardiac tumors. Pediatr Cardiol. 2004;25:252–73.10.1007/s00246-003-0590-4Search in Google Scholar
[9] Chan HS, Sonley MJ, Moës CA, Daneman A, Smith CR, Martin DJ. Primary and secondary tumors of childhood involving the heart, pericardium, and great vessels. A report of 75 cases and review of the literature. Cancer 1985;56:825–36.10.1002/1097-0142(19850815)56:4<825::AID-CNCR2820560421>3.0.CO;2-7Search in Google Scholar
[10] Farooki ZQ, Ross RD, Paridon SM, Humes RA, Karpawich PP, Pinsky WW. Spontaneous regression of cardiac rhabdomyoma. Am J Cardiol. 1991;67:897–9.10.1016/0002-9149(91)90629-YSearch in Google Scholar
[11] Zhang JH, Ma H, Cao YF, Du XL, Guo JX, Yan HZ, et al. Echocardiographic performance of a case of fetal left ventricular fibroma. Chin J Ultrasonogr. 2005;4:827. [Article in Chinese]Search in Google Scholar
[12] Sepulveda W, Gómez E, Gutiérrez J. Intrapericardial teratoma. Ultrasound Obstet Gynecol. 2000;15:547–8.10.1046/j.1469-0705.2000.00144.xSearch in Google Scholar
[13] Tollens T, Casselman F, Devlieger H, Gewillig MH, Vandenberghe K, Lerut TE, et al. Fetal cardiac tamponade due to an intrapericardial teratoma. Ann Thorac Surg. 1998;66:559–60.10.1016/S0003-4975(98)00508-6Search in Google Scholar
[14] Rychik J, Khalek N, Gaynor JW, Johnson MP, Adzick NS, Flake AW, et al. Fetal intrapericardial teratoma: natural history and management including successful in utero surgery. Am J Obstet Gynecol. 2016;215:780.e1–7.10.1016/j.ajog.2016.08.010Search in Google Scholar
[15] Grebenc ML, Rosado de Christenson ML, Burke AP, Green CE, Galvin JR. Primary cardiac and pericardial neoplasms: radiologic-pathologic correlation. Radiographics. 2000;20:1073–103; quiz 1110-1, 1112.10.1148/radiographics.20.4.g00jl081073Search in Google Scholar
[16] Thorp JA, Geidt A, Gelatt M, Gowdamarajan R. Decompression of fetal cardiac tamponade caused by congenital capillary hemangioma of the pericardium. Obstet Gynecol. 2000;96(5 Pt 2):816–7.10.1016/S0029-7844(00)01045-0Search in Google Scholar
[17] Pucci A, Botta G, Sina N, Tibaldi M, Valori A, Grosso E, et al. Life-threatening tumors of the heart in fetal and postnatal age. J Pediatr. 2013;162:964–9.e1.10.1016/j.jpeds.2012.10.055Search in Google Scholar PubMed
[18] Rajiah P, Mak C, Dubinksy TJ, Dighe M. Ultrasound of fetal cardiac anomalies. AJR Am J Roentgenol. 2011;197:W747–60.10.2214/AJR.10.7287Search in Google Scholar PubMed
[19] Pruksanusak N, Suntharasaj T, Suwanrath C, Phukaoloun M, Kanjanapradit K. Fetal cardiac rhabdomyoma with hydrops fetalis: report of 2 cases and literature review. J Ultrasound Med. 2012;31:1821–4.10.7863/jum.2012.31.11.1821Search in Google Scholar PubMed
[20] Chao AS, Chao A, Wang TH, Chang YC, Chang YL, Hsieh CC, et al. Outcome of antenatally diagnosed cardiac rhabdomyoma: case series and a meta-analysis. Ultrasound Obstet Gynecol. 2008;31:289–95.10.1002/uog.5264Search in Google Scholar PubMed
[21] Miyake CY, Del Nido PJ, Alexander ME, Cecchin F, Berul CI, Triedman JK, et al. Cardiac tumors and associated arrhythmias in pediatric patients, with observations on surgical therapy for ventricular tachycardia. J Am Coll Cardiol. 2011;58:1903–9.10.1016/j.jacc.2011.08.005Search in Google Scholar PubMed
[22] Muñoz H, Sherer DM, Romero R, Sanchez J, Hernandez I, Diaz C. Prenatal sonographic findings of a large fetal cardiac fibroma. J Ultrasound Med. 1995;14:479–81.10.7863/jum.1995.14.6.479Search in Google Scholar PubMed
[23] Saada J, Hadj Rabia S, Fermont L, Le Bidois J, Bernardes LS, Martinovic J, et al. Prenatal diagnosis of cardiac rhabdomyomas: incidence of associated cerebral lesions of tuberous sclerosis complex. Ultrasound Obstet Gynecol. 2009;34:155–9.10.1002/uog.6367Search in Google Scholar
[24] Zhang YX, Meng H, Zhong DR, Jiang YX, Dai Q, Zhang H. Cardiac rhabdomyoma and renal cyst in a fetus: early onset of tuberous sclerosis with renal cystic disease. J Ultrasound Med. 2008;27:979–82.10.7863/jum.2008.27.6.979Search in Google Scholar
[25] Niewiadomska-Jarosik K, Stańczyk J, Janiak K, Jarosik P, Moll JJ, Zamojska J, et al. Prenatal diagnosis and follow-up of 23 cases of cardiac tumors. Prenat Diagn. 2010;30:882–7.10.1002/pd.2586Search in Google Scholar
[26] O’Donnell DH, Abbara S, Chaithiraphan V, Yared K, Killeen RP, Cury RC, et al. Cardiac tumors: optimal cardiac MR sequences and spectrum of imaging appearances. AJR Am J Roentgenol. 2009;193:377–87.10.2214/AJR.08.1895Search in Google Scholar
[27] Kitagawa N, Ohhama Y, Fukuzato Y, Take H, Shinkai M, Nishi T, et al. Pericardial hemangioma presenting fetal cardiac tamponade and postnatal bronchostenosis. Pediatr Surg Int. 2004;20:376–7.10.1007/s00383-004-1202-ySearch in Google Scholar
[28] Guimarães Filho HA, Araujo Junior E, Pires CR, Costa LL, Nardozza LM, Mattar R. Prenatal sonographic diagnosis of fetal cardiac rhabdomyoma: a case report. Radiol Bras. 2009;42:203–5.10.1590/S0100-39842009000300015Search in Google Scholar
[29] Karatas A, Karatas Z, Ozlu1 T. Fetal cardiac rhabdomyoma without tuberous sclerosis: a case report. Int J Med Sci Public Health. 2013;2:1095–7.10.5455/ijmsph.2013.290820131Search in Google Scholar
[30] de Bustamante TD, Azpeitia J, Miralles M, Jiménez M, Santos-Briz A, Rodríguez-Peralto JL. Prenatal sonographic detection of pericardial teratoma. J Clin Ultrasound. 2000;28:194–8.10.1002/(SICI)1097-0096(200005)28:4<194::AID-JCU8>3.0.CO;2-1Search in Google Scholar
[31] Kamil D, Geipel A, Schmitz C, Breuer J, Herberg U, Knöpfle G, et al. Fetal pericardial teratoma causing cardiac insufficiency: Prenatal diagnosis and therapy. Ultrasound Obstet Gynecol. 2006;28:972–3.10.1002/uog.3829Search in Google Scholar
[32] Liu DQ, Yin HM, Jiang YY. Ultrasound diagnosis of a case of fetal multiple cardiac fibroma. Chin J Med Ultrosound (Electronic Edition). 2009;6:14. [Article in Chinese]Search in Google Scholar
[33] Tseng JJ, Chou MM, Lee YH, Ho ES. In utero diagnosis of cardiac hemangioma. Ultrasound Obstet Gynecol. 1999;13:363–5.10.1046/j.1469-0705.1999.13050363.xSearch in Google Scholar
[34] Tongsong T, Sirichotiyakul S, Sittiwangkul R, Wanapirak C. Prenatal sonographic diagnosis of cardiac hemangioma with postnatal spontaneous regression. Ultrasound Obstet Gynecol. 2004;24:207–8.10.1002/uog.1102Search in Google Scholar
[35] Ríos JC, Chávarri F, Morales G, Vera L, Adrianzén M, Abarca A, et al. Cardiac myxoma with prenatal diagnosis. World J Pediatr Congenit Heart Surg. 2013;4:210–2.10.1177/2150135112472210Search in Google Scholar
[36] Paladini D, Tartaglione A, Vassallo M, Martinelli P. Prenatal ultrasonographic findings of a cardiac myxoma. Obstet Gynecol. 2003;102(5 Pt 2):1174–6.10.1016/S0029-7844(03)00079-6Search in Google Scholar
[37] Xu ZY. Echocardiographic evaluation of fetal cardiac myxoma. J Med Imag. 2006;15:213–4. [Article in Chinese]Search in Google Scholar
[38] Kivelitz DE, Mühler M, Rake A, Scheer I, Chaoui R. MRI of cardiac rhabdomyoma in the fetus. Eur Radiol. 2004;14:1513–6.10.1007/s00330-003-2062-xSearch in Google Scholar
[39] Fagiana AM, Barnett S, Reddy VS, Milhoan KA. Management of a fetal intrapericardial teratoma: a case report and review of the literature. Congenit Heart Dis. 2010;5:51–5.10.1111/j.1747-0803.2009.00305.xSearch in Google Scholar
[40] Kim TH, Kim YM, Han MY, Kim WH, Oh MH, Han KS. Perinatal sonographic diagnosis of cardiac fibroma with MR imaging correlation. AJR Am J Roentgenol. 2002;178:727–9.10.2214/ajr.178.3.1780727Search in Google Scholar
[41] Sharma J, Hirata Y, Mosca RS. Surgical repair in neonatal life of cardiac haemangiomas diagnosed prenatally. Cardiol Young. 2009;19:403–6.10.1017/S1047951109004168Search in Google Scholar
[42] Tollens M, Grab D, Lang D, Hess J, Oberhoffer R. Pericardial teratoma: prenatal diagnosis and course. Fetal Diagn Ther. 2003;18:432–6.10.1159/000073138Search in Google Scholar
[43] Daniels CJ, Cohen DM, Phillips JR, Rowland DG. Prenatal detection of a pericardial teratoma. Circulation. 1999;99:E1–2.10.1161/01.CIR.99.2.e1Search in Google Scholar
[44] Xing RG, Wang CL, Gao Y. An autopsy of an 8-month preterm infant with cardiac lipoma. Chin J Diagn Pathol. 2009;16:232. [Article in Chinese]Search in Google Scholar
[45] Eckstein FS, Heinemann MK, Mielke GJ, Greschniok A, Bader P, Ziemer G. Resection of a large right atrial hemangioma in a neonate after prenatal diagnosis. Ann Thorac Surg. 1999;68:1074–5.10.1016/S0003-4975(99)00659-1Search in Google Scholar
[46] Wacker-Gussmann A, Strasburger JF, Cuneo BF, Wiggins DL, Gotteiner NL, Wakai RT. Fetal arrhythmias associated with cardiac rhabdomyomas. Heart Rhythm. 2014;11:677–83.10.1016/j.hrthm.2013.12.018Search in Google Scholar
[47] Killen SA, Fish FA. Fetal and Neonatal arrhythmias. Neo Rev. 2008;9;e242–52.10.1542/neo.9-6-e242Search in Google Scholar
[48] Peters M, Crowe J, Piéri JF, Quartero H, Hayes-Gill B, James D, et al. Monitoring the fetal heart non-invasively: a review of methods. J Perinat Med. 2001;29:408–16.10.1515/JPM.2001.057Search in Google Scholar
[49] Lewis MJ. Review of electromagnetic source investigations of the fetal heart. Med Eng Phys. 2003;25:801–10.10.1016/S1350-4533(03)00121-8Search in Google Scholar
[50] van Leeuwen P, Schüssler M, Bettermann H, Lange S, Hatzmann W. Magnetocardiography for assessment of fetal heart actions. Geburtshilfe Frauenheilkd. 1995;55:642–6. [Article in German]10.1055/s-2007-1023539Search in Google Scholar
[51] Hosono T, Kanagawa T, Chiba Y, Kandori A, Tsukada K. The coincidence of fetal magnetocardiography and direct electrocardiography in a case of fetal atrial flutter due to intracardiac tumor. Fetal Diagn Ther. 2002;17:331–3.10.1159/000065379Search in Google Scholar
[52] Atallah J, Robertson M, Rebeyka IM, Dyck J, Noga ML. Antenatal diagnosis and successful surgical removal of a large right ventricular fibroma. Pediatr Cardiol. 2006;27:493–6.10.1007/s00246-006-1260-0Search in Google Scholar
[53] Grebille AG, Mitanchez D, Benachi A, Aubry MC, Houfflin-Debarge V, Vouhé P, et al. Pericardial teratoma complicated by hydrops: successful fetal therapy by thoracoamniotic shunting. Prenat Diagn. 2003;23:735–9.10.1002/pd.698Search in Google Scholar
[54] Ragupathy R, Nemeth L, Kumaran V, Rajamani G, Krishnamoothy P. Successful surgical management of a prenatally diagnosed intrapericardial teratoma. Pediatr Surg Int. 2003;19:737–9.10.1007/s00383-003-0969-6Search in Google Scholar
[55] Paw PT, Jamieson SW. Surgical management of intrapericardial teratoma diagnosed in utero. Ann Thorac Surg. 1997;64: 552–4.10.1016/S0003-4975(97)00585-7Search in Google Scholar
[56] Leithiser RE Jr, Fyfe D, Weatherby E 3rd, Sade R, Garvin AJ. Prenatal sonographic diagnosis of atrial hemangioma. AJR Am J Roentgenol. 1986;147:1207–8.10.2214/ajr.147.6.1207Search in Google Scholar PubMed
[57] Baird C, Blalock S, Bengur R, Ikemba C. Right atrial hemangioma in the newborn: Utility of fetal imaging. Ann Pediatr Cardiol. 2012;5:81–4.10.4103/0974-2069.93719Search in Google Scholar PubMed PubMed Central
[58] Puligandla PS, Kay S, Morin L, Desilets V, Jutras L, Shum-Tim D, et al. Pericardial hemangioma presenting as thoracic mass in utero. Fetal Diagn Ther. 2004;19:178–81.10.1159/000075146Search in Google Scholar PubMed
[59] Kang ZH, Liu AW. Fetal echocardiography. VI. A case of left ventricular lipoblastoma. J Harbin Med Univ. 1991;25:273–4. [Article in Chinese]Search in Google Scholar
[60] Li CQ, Zhang S, Wei B. A case of fetal ventricular lipoblastoma. J Pract Obstet Gynecol. 2012;28:495. [Article in Chinese]Search in Google Scholar
[61] Meng HZ, Sun XP, Zhou SJ. A case of fetal cardiac liposarcoma. Chin J Med Imag. 2013;21:240. [Article in Chinese]Search in Google Scholar
[62] Gao J, Wang FN, Chu W. Prenatal diagnosis of a case of malignant cardiac tumor. Chin J Birth Health Hered. 2010;18:106,11. [Article in Chinese]Search in Google Scholar
[63] Liu SX. The diagnostic value of color Doppler echocardiography in the diagnosis of primary cardiac tumors. Chin Cont Med Edu. 2015;7:35–6. [Article in Chinese]Search in Google Scholar
[64] Sebastian V, Einzig S, D’Cruz C, Costello C, Kula M, Campbell A. Cardiac hemangioma of the right atrium in a neonate: fetal management and expedited surgical resection. Images Paediatr Cardiol. 2005;7:5–9.Search in Google Scholar
[65] Zhou QC, Fan P, Peng QH, Zhang M, Fu Z, Wang CH. Prenatal echocardiographic differential diagnosis of fetal cardiac tumors. Ultrasound Obstet Gynecol. 2004;23:165–71.10.1002/uog.979Search in Google Scholar PubMed
©2018 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review article
- Fetal cardiac tumors: clinical features, management and prognosis
- Original articles – Obstetrics
- Chronic inflammatory lesions of the placenta are associated with an up-regulation of amniotic fluid CXCR3: A marker of allograft rejection
- Gaps in obstetric care processes – we can only improve what is being measured
- Tokophobia (fear of childbirth): prevalence and risk factors
- Adjuvant administration of 17-α-hydroxy-progesterone caproate in women with three or more second trimester pregnancy losses undergoing cervical cerclage is no more effective than cerclage alone
- The role of ultrasound in the prediction of birth weight discordance in twin pregnancies: are we there yet?
- NLRP genes and their role in preeclampsia and multi-locus imprinting disorders
- Original articles – Fetus
- Diagnostic value of perinatal autopsies: analysis of 486 cases
- Feto-maternal osmotic balance at term. A prospective observational study
- Original articles – Newborn
- Oxygen saturation trends in normal healthy term newborns: normal vaginal delivery vs. elective cesarean section
- Causes of death among full term stillbirths and early neonatal deaths in the Region of Southern Denmark
- Critical congenital heart disease screening with a pulse oximetry in neonates
- DHA reduces oxidative stress following hypoxia-ischemia in newborn piglets: a study of lipid peroxidation products in urine and plasma
- A non-invasive method to rule out transient tachypnea of the newborn (TTN): fetal pulmonary artery acceleration to ejection time ratio
- Letter to the Editor
- Clarification of the methods and statistics in the study “Planned home birth and the association with neonatal hypoxic ischemic encephalopathy”
- Clarification of the methods and statistics in the study “Planned home birth and the association with neonatal hypoxic ischemic encephalopathy”
- Reply to: Planned home birth and the association with neonatal hypoxic ischemic encephalopathy
- Response to the Letter to the Editor, “Risk factors of uterine rupture with a special interest to uterine fundal pressure: methodological issues”
- Re: Utility of routine urine CMV PCR and total serum IgM testing of small for gestational age infants: a single center review
Articles in the same Issue
- Frontmatter
- Review article
- Fetal cardiac tumors: clinical features, management and prognosis
- Original articles – Obstetrics
- Chronic inflammatory lesions of the placenta are associated with an up-regulation of amniotic fluid CXCR3: A marker of allograft rejection
- Gaps in obstetric care processes – we can only improve what is being measured
- Tokophobia (fear of childbirth): prevalence and risk factors
- Adjuvant administration of 17-α-hydroxy-progesterone caproate in women with three or more second trimester pregnancy losses undergoing cervical cerclage is no more effective than cerclage alone
- The role of ultrasound in the prediction of birth weight discordance in twin pregnancies: are we there yet?
- NLRP genes and their role in preeclampsia and multi-locus imprinting disorders
- Original articles – Fetus
- Diagnostic value of perinatal autopsies: analysis of 486 cases
- Feto-maternal osmotic balance at term. A prospective observational study
- Original articles – Newborn
- Oxygen saturation trends in normal healthy term newborns: normal vaginal delivery vs. elective cesarean section
- Causes of death among full term stillbirths and early neonatal deaths in the Region of Southern Denmark
- Critical congenital heart disease screening with a pulse oximetry in neonates
- DHA reduces oxidative stress following hypoxia-ischemia in newborn piglets: a study of lipid peroxidation products in urine and plasma
- A non-invasive method to rule out transient tachypnea of the newborn (TTN): fetal pulmonary artery acceleration to ejection time ratio
- Letter to the Editor
- Clarification of the methods and statistics in the study “Planned home birth and the association with neonatal hypoxic ischemic encephalopathy”
- Clarification of the methods and statistics in the study “Planned home birth and the association with neonatal hypoxic ischemic encephalopathy”
- Reply to: Planned home birth and the association with neonatal hypoxic ischemic encephalopathy
- Response to the Letter to the Editor, “Risk factors of uterine rupture with a special interest to uterine fundal pressure: methodological issues”
- Re: Utility of routine urine CMV PCR and total serum IgM testing of small for gestational age infants: a single center review