Correlation of cervical length, fetal fibronectin, phIGFBP-1, and cytokines in spontaneous preterm birth up to 14 days from sampling
Abstract
Objective: The aim of this study was to determine the relationship between sonographic cervical length, fetal fibronectin (fFN), phIGFBP-1 (actim partus test), cytokines (IL-6, IL-2R, and TNF-α), and spontaneous preterm birth (SPTB) up to 14 days from sampling.
Methods: Fifty-eight patients were recruited in a period of 6 months from September 2013 until March 2014 with symptoms or complaints suggestive of preterm labor. Consenting women were treated according to usual hospital protocol, with addition of vaginal swabs taken for fetal fibronectin, phIGFBP-1 (actim partus test) and cervical IL6, IL2R, and TNF-α. The outcome variable was occurrence of preterm delivery within 14 days from the day of hospital admission.
Results: Thirty-six patients (62.07%) were delivered within 14 days from admission. Our results indicated that the cervical length significantly inversely correlates with the concentration of IL-6 in the CVF (Spearman’s coefficient R=–0.382, P<0.05). Cervical length also correlated with a positive phIGFBP-1 test, i.e., patients with a positive test had an average cervical length of 18.5±4.63 mm, which is significantly lower than patients with a negative test –23.43±7.39 mm (P=0.003).
Conclusions: The studied biochemical markers were only moderately successful in the prediction of preterm delivery.
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The authors stated that there are no conflicts of interest regarding the publication of this article.
©2015 by De Gruyter
Articles in the same Issue
- Frontmatter
- Editorial
- Risk factors for preterm birth and new approaches to its early diagnosis
- Review
- Avoiding the prenatal programming effects of glucocorticoids: are there alternative treatments for the induction of antenatal lung maturation?
- Original articles – Obstetrics
- The association of first trimester bleeding with preterm delivery
- Cervical sonoelastography for improving prediction of preterm birth compared with cervical length measurement and fetal fibronectin test
- The neuroprotective effect of magnesium sulfate in preterm fetal mice
- Correlation of cervical length, fetal fibronectin, phIGFBP-1, and cytokines in spontaneous preterm birth up to 14 days from sampling
- The unborn smoker: association between smoking during pregnancy and adverse perinatal outcomes
- Association of group B streptococcus colonization with early term births
- Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions: a cross-sectional study
- Predicting onset of labor from echogenicity of the cervical gland area on vaginal ultrasonography at term
- Disparity in post-treatment maternal circulating magnesium sulfate levels between twin and singleton gestation: Is this the missing link between plurality and adverse outcome?
- Original articles – Fetus
- Cardiovascular profile score in 44 fetuses with cervicofacial tumors
- First trimester tricuspid regurgitation and fetal abnormalities
- Gastroschisis: incidence and prediction of growth restriction
- Original articles – Newborn
- Diminished HLA-DR expression on monocyte and dendritic cell subsets indicating impairment of cellular immunity in pre-term neonates: a prospective observational analysis
- First- and fifth-minute Apgar scores of 0–3 and infant mortality: a population-based study in São Paulo State of Brazil
- Feeding the feeble: steps towards nourishing preterm infants
- Book review
- Hot topics in perinatal medicine
- Erratum
- Erratum to: Impact of the nitric oxide-donor pentaerythrityl-tetranitrate on perinatal outcome in risk pregnancies: a prospective, randomized, double-blinded trial
- Congress Calendar
- Congress Calendar
Articles in the same Issue
- Frontmatter
- Editorial
- Risk factors for preterm birth and new approaches to its early diagnosis
- Review
- Avoiding the prenatal programming effects of glucocorticoids: are there alternative treatments for the induction of antenatal lung maturation?
- Original articles – Obstetrics
- The association of first trimester bleeding with preterm delivery
- Cervical sonoelastography for improving prediction of preterm birth compared with cervical length measurement and fetal fibronectin test
- The neuroprotective effect of magnesium sulfate in preterm fetal mice
- Correlation of cervical length, fetal fibronectin, phIGFBP-1, and cytokines in spontaneous preterm birth up to 14 days from sampling
- The unborn smoker: association between smoking during pregnancy and adverse perinatal outcomes
- Association of group B streptococcus colonization with early term births
- Association of maternal whole blood fatty acid status during the prenatal period with term birth dimensions: a cross-sectional study
- Predicting onset of labor from echogenicity of the cervical gland area on vaginal ultrasonography at term
- Disparity in post-treatment maternal circulating magnesium sulfate levels between twin and singleton gestation: Is this the missing link between plurality and adverse outcome?
- Original articles – Fetus
- Cardiovascular profile score in 44 fetuses with cervicofacial tumors
- First trimester tricuspid regurgitation and fetal abnormalities
- Gastroschisis: incidence and prediction of growth restriction
- Original articles – Newborn
- Diminished HLA-DR expression on monocyte and dendritic cell subsets indicating impairment of cellular immunity in pre-term neonates: a prospective observational analysis
- First- and fifth-minute Apgar scores of 0–3 and infant mortality: a population-based study in São Paulo State of Brazil
- Feeding the feeble: steps towards nourishing preterm infants
- Book review
- Hot topics in perinatal medicine
- Erratum
- Erratum to: Impact of the nitric oxide-donor pentaerythrityl-tetranitrate on perinatal outcome in risk pregnancies: a prospective, randomized, double-blinded trial
- Congress Calendar
- Congress Calendar