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Sarcoidosis and pregnancy: obstetrical and neonatal outcomes in a population-based cohort of 7 million births

  • Vicky Hadid , Valerie Patenaude , Lisa Oddy and Haim A. Abenhaim EMAIL logo
Published/Copyright: June 17, 2014

Abstract

Objectives: Data on sarcoidosis in pregnancy is sparse and limited to a few case reports and series. Our aim is to determine the prevalence of sarcoidosis at delivery, and related maternal and newborn outcomes.

Study design: Using the United States Healthcare Cost and Utilization Project Nationwide Inpatient Sample (HCUP-NIS) from 2003 to 2010, we conducted a population-based retrospective cohort study to compare women with and without sarcoidosis at delivery. We calculated the prevalence of sarcoidosis in pregnancy and used logistic regression analyses to estimate the associated risks of maternal and neonatal outcomes.

Results: There were 678 cases of sarcoidosis in 7,094,400 births over an 8-year period for an overall prevalence of nine and six-tenths cases per 100,000 births. Compared with controls, women with sarcoidosis were older, more likely to be African American and to report being smokers. Women with sarcoidosis were more likely to have preeclampsia odds ratio (OR) 1.62 (95% CI 1.18–2.22), eclampsia OR 5.27 (95% CI 1.69–16.40), deep vein thrombosis OR 4.92 (95% CI 1.58–15.33), pulmonary embolism OR 6.68 (95% CI 3.99–11.21), and premature delivery OR 1.73 (95% CI 1.40–2.15). There was also an increased risk of cesarean deliveries and postpartum hemorrhages. There were no cases of maternal death reported.

Conclusions: Sarcoidosis in pregnancy is a rare disease associated with an increased risk of adverse obstetrical outcomes. Women with sarcoidosis can carry out successful pregnancies, however should be made aware of the higher risk of adverse events. Given the higher risk of venous thromboembolic events, consideration should be given to thromboprophylaxis in pregnancy.


Corresponding author: Haim A. Abenhaim, MD, MPH, FRCSC, Jewish General Hospital, Obstetrics and Gynecology, Centre for Clinical Epidemiology and Community Studies, 5790 Cote-Des-Neiges Road, Pav H, Room 325, Montreal, Quebec H3S 1Y9, Canada, Tel.: +514-340-8222 x5488, Fax: +514-340-7941, E-mail:

Acknowledgments

Special thanks to Sophie Villeneuve, a 4th year McGill medical student, for assisting in the literature review.

Conflict of interest statement

Authors’ conflict of interest disclosure: The authors declare no conflicts of interest.

Funding: Funding was obtained from our institution.

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The authors stated that there are no conflicts of interest regarding the publication of this article.

Received: 2014-1-14
Accepted: 2014-5-19
Published Online: 2014-6-17
Published in Print: 2015-3-1

©2015 by De Gruyter

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