Ethnic disparity in amniotic fluid levels of hyaluronan, histone H2B and superoxide dismutase in spontaneous preterm birth
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Catherine Herway
, Tomi Kanninen
, Steven S. Witkin , George Saade , Stephen J. Fortunato und Ramkumar Menon
Abstract
Aims: To document racial disparity in an immune modulator, hyaluronan (HA), an antimicrobial, histone H2B (H2B), and an antioxidant, superoxide dismutase (SOD) in amniotic fluid (AF) from African-American (AA) and Caucasian (C) subjects with spontaneous preterm birth (PTB).
Methods: In a case (PTB) control (term) study, AF samples were analyzed for HA, H2B and SOD by ELISA. Differences in analyte concentrations between races were documented and a secondary analysis based on histologic chorioamnionitis (HC) was also performed.
Results: No differences in the median HA, H2B and SOD were seen between cases and controls. AA cases had lower HA but higher H2B and SOD than controls. Analyte concentrations were not different between C cases and controls. AA samples at term had lower H2B and SOD compared to C samples at term. Cases with HC showed higher H2B and SOD.
Conclusion: We report ethnic disparity in AF antimicrobial, immune mediator and antioxidant factors. Dysregulated AF production of HA, H2B and SOD was associated with PTB in AA, not in C, suggesting an overwhelming inflammatory response in AA PTB, whereas inflammation is likely a secondary phenomenon in C PTB.
The authors stated that there are no conflicts of interest regarding the publication of this article.
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- Congress Calendar
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Artikel in diesem Heft
- Masthead
- Masthead
- Review
- The diagnosis of rupture of fetal membranes (ROM): a meta-analysis
- Original Articles – Obstetrics
- Differential proteolysis of insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy
- Hyperoxic resuscitation after hypoxia-ischemia induces cerebral inflammation that is attenuated by tempol in a reporter mouse model with very young mice
- Prenatal maternal stress predicts cord-blood ferritin concentration
- Puerperal curettage after cesarean section delivery
- Psychological reactions related to fetal magnetic resonance imaging: a follow-up study
- Ethnic disparity in amniotic fluid levels of hyaluronan, histone H2B and superoxide dismutase in spontaneous preterm birth
- Mode of delivery in a subsequent pregnancy following previous instrumental delivery
- Original Articles – Fetus
- Pregnancy and neonatal outcome following an antenatal diagnosis of cleft lip and palate
- Genetic low nephron number hypertension is associated with altered expression of osteopontin and CD44 during nephrogenesis*
- Pharmacovigilance in pregnancy: adverse drug reactions associated with fetal disorders
- Expectant management in type II selective intrauterine growth restriction and abnormal chord insertion in monochorionic twins
- Can prenatal detection of Down syndrome be improved by enhancing obstetricians’ skills of performing adequate foetal cardiac examination at the primary level?a
- Original Articles – Newborn
- The national perinatal mortality rate in the State of Qatar during 2011; trends since 1990 and comparative analysis with selected high-income countries: The PEARL Study Project*
- Determinants of successful breastfeeding initiation in healthy term singletons: a Swiss university hospital observational study
- Congress Calendar
- Congress Calendar