Genetic low nephron number hypertension is associated with altered expression of osteopontin and CD44 during nephrogenesis*
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Anne Freese
, Markus Wehland
, Florian Freese , Christian Bamberg , Reinhold Kreutz und Lars Rothermund
Abstract
Aims: The study set out to investigate whether the osteopontin (OPN)-CD44-integrin-receptor-system is differently regulated during nephrogenesis in inborn nephron deficit, a major determinant of human primary hypertension and cardiovascular disease in adult life.
Methods: We compared a genetic rat model with an inherited nephron deficit, the Munich-Wistar-Froemter rat (MWF), to normotensive Wistar rats during nephrogenesis at day 19 of fetal development (E19) and at postpartal day 7 (D7).
Results: Renal OPN mRNA (–75%, P<0.05) and protein expression (–38%, P<0.05) were strongly decreased at E19 in MWF compared to Wistar. Renal mRNA-expression of CD44 was increased at E19 in MWF (+271%, P<0.05). At D7, renal OPN protein expression was increased (+115%, P<0.05) and renal mRNA-expression of CD44 remained elevated compared to Wistar control (+127%, P<0.05).
Conclusions: Altered fetal expression of the OPN-CD44-integrin-receptor-system in the MWF model points to a possible role in low nephron number hypertension and cardiovascular disease.
The authors stated that there are no conflicts of interest regarding the publication of this article.
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Supported by the Deutsche Forschungsgemeinschaft: (DFG, Grant RO 2124/2-1 and RO 2124/2-2).
References
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Artikel in diesem Heft
- Masthead
- Masthead
- Review
- The diagnosis of rupture of fetal membranes (ROM): a meta-analysis
- Original Articles – Obstetrics
- Differential proteolysis of insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy
- Hyperoxic resuscitation after hypoxia-ischemia induces cerebral inflammation that is attenuated by tempol in a reporter mouse model with very young mice
- Prenatal maternal stress predicts cord-blood ferritin concentration
- Puerperal curettage after cesarean section delivery
- Psychological reactions related to fetal magnetic resonance imaging: a follow-up study
- Ethnic disparity in amniotic fluid levels of hyaluronan, histone H2B and superoxide dismutase in spontaneous preterm birth
- Mode of delivery in a subsequent pregnancy following previous instrumental delivery
- Original Articles – Fetus
- Pregnancy and neonatal outcome following an antenatal diagnosis of cleft lip and palate
- Genetic low nephron number hypertension is associated with altered expression of osteopontin and CD44 during nephrogenesis*
- Pharmacovigilance in pregnancy: adverse drug reactions associated with fetal disorders
- Expectant management in type II selective intrauterine growth restriction and abnormal chord insertion in monochorionic twins
- Can prenatal detection of Down syndrome be improved by enhancing obstetricians’ skills of performing adequate foetal cardiac examination at the primary level?a
- Original Articles – Newborn
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