Pregnancy and neonatal outcome following an antenatal diagnosis of cleft lip and palate
-
Bénédicte Michel
, Christian Debauche
, Graham Hutchings , Pierre Bernard , Jean-Marc Biard , Geneviève François , Bénédicte Bayet und Olivia Williams
Abstract
Aim: To identify the significance of associated antenatal ultrasound findings on long-term prognosis following the antenatal diagnosis of cleft lip/palate [CL(P)].
Patients and methods: Retrospective case note analysis of patients seen at a single tertiary referral centre with a diagnosis of CL(P). The patients were classified as those with unilateral or bilateral clefts and then further subdivided according to the presence of associated anomalies, and these were related to pregnancy and neonatal outcome.
Results: A total of 125 singleton pregnancies were seen at the antenatal diagnostic unit, 14 of which were subsequently lost to follow-up. Eighty-two (65.6%) had a diagnosis of unilateral CL(P) and 43 (34.4%) a bilateral CL(P). Seventy-five foetuses (67.5%) had no other anomalies detected on antenatal ultrasound. Seventeen patients (15%) underwent a termination of pregnancy. A normal postnatal outcome was seen in 79% of liveborn infants overall. Only 50% of foetuses diagnosed with a single minor anomaly and 4% of the foetuses in whom more than two minor anomalies or one major anomaly had been detected on ultrasound had a normal postnatal outcome. Infants with bilateral CL(P) had a significantly reduced incidence of a normal postnatal course (60% vs. 87.5%, P<0.01).
Conclusion: In cases of CL(P), there is a high incidence of associated anomalies detected on antenatal ultrasound and these significantly increase the risk of poor neonatal outcome.
References
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Artikel in diesem Heft
- Masthead
- Masthead
- Review
- The diagnosis of rupture of fetal membranes (ROM): a meta-analysis
- Original Articles – Obstetrics
- Differential proteolysis of insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy
- Hyperoxic resuscitation after hypoxia-ischemia induces cerebral inflammation that is attenuated by tempol in a reporter mouse model with very young mice
- Prenatal maternal stress predicts cord-blood ferritin concentration
- Puerperal curettage after cesarean section delivery
- Psychological reactions related to fetal magnetic resonance imaging: a follow-up study
- Ethnic disparity in amniotic fluid levels of hyaluronan, histone H2B and superoxide dismutase in spontaneous preterm birth
- Mode of delivery in a subsequent pregnancy following previous instrumental delivery
- Original Articles – Fetus
- Pregnancy and neonatal outcome following an antenatal diagnosis of cleft lip and palate
- Genetic low nephron number hypertension is associated with altered expression of osteopontin and CD44 during nephrogenesis*
- Pharmacovigilance in pregnancy: adverse drug reactions associated with fetal disorders
- Expectant management in type II selective intrauterine growth restriction and abnormal chord insertion in monochorionic twins
- Can prenatal detection of Down syndrome be improved by enhancing obstetricians’ skills of performing adequate foetal cardiac examination at the primary level?a
- Original Articles – Newborn
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