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Comparison of risk calculation approaches in a screening programme for Down syndrome

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Published/Copyright: January 23, 2012
Journal of Perinatal Medicine
From the journal Volume 40 Issue 3

Abstract

In the Netherlands, both the LifeCycle Elipse (LC) and the Astraia software package are used to calculate the risk of having a child with Down syndrome. Therefore, pregnant women can be presented with dissimilar risks. In this study the conformity between these risks before and after harmonization of the screening program and its influence on the performance indicators of the first trimester screening were evaluated. The agreement between combined risks (based on the biochemical parameters PAPP-A and fβ-hCG and a nuchal translucency measurement) was expressed as intraclass correlation coefficient (ICC)=0.99. Conformity between combined risks was better after harmonization (Cohen’s κ=0.75) than before harmonization (Cohen’s κ=0.63). For both risk calculation software packages the area under the ROC-curve was 0.84. The database contained 42 Down syndrome cases; based on the odds of being affected given a positive result (OAPR), LC performed slightly better than Astraia before harmonization (17.9 vs. 21.5, respectively). It has been acknowledged that using different software packages could lead to dissimilar risk calculations. In this study the screening performance indicators of two software packages were quite similar. The agreement of the screening performance after harmonization remains to be seen, but is expected to be even higher.

Keywords: Astraia; Down syndrome; LifeCycle Elipse; prenatal screening, risk calculation
Corresponding author: Dr. Peter C.J.I. Schielen Laboratory for Infectious Diseases and Screening National Institute for Public Health and the Environment (RIVM)PO Box 1, 3720 BA Bilthoven The Netherlands
Received: 2011-5-16
Revised: 2011-12-13
Accepted: 2011-12-19
Published Online: 2012-01-23
Published in Print: 2012-04-01

©2012 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/jpm-2011-0121
Keywords for this article
Astraia; Down syndrome; LifeCycle Elipse; prenatal screening, risk calculation

Articles in the same Issue

  1. Review Article
  2. Retinal microvascular changes in low-birth-weight babies have a link to future health
  3. Original Articles – Obstetrics
  4. Chromosomal mosaicisms in prenatal diagnosis: correlation with first trimester screening and clinical outcome
  5. Perinatal impact of the use of metformin and glyburide for the treatment of gestational diabetes mellitus
  6. Incidence and causes of maternal thrombocytopenia in triplet gestation
  7. Maternal and paternal age and twinning in the United States, 2004–2008
  8. Correlates of the trend of cesarean section rates in twin pregnancies
  9. Prospective risk of stillbirth: monochorionic diamniotic twins vs. dichorionic twins
  10. Association between increased yolk sac diameter and abnormal karyotypes
  11. No “masculinization” effect of a male on birth weight of its female co-twin
  12. Comparison of risk calculation approaches in a screening programme for Down syndrome
  13. Individual decisions in placenta increta and percreta: a case series
  14. Original Articles – Fetus
  15. Fetal sex and perinatal outcomes
  16. Fetal magnetocardiography (fMCG): moving forward in the establishment of clinical reference data by advanced biomagnetic instrumentation and analysis
  17. Maternal and fetal cord blood lipids in intrauterine growth restriction
  18. Assessment of long-axis ventricular function in the fetal heart with a tissue-tracking algorithm
  19. Original Articles – Newborn
  20. A cluster of methicillin-sensitive Staphylococcus aureus colonization in a nursery
  21. Intermittent flushing improves cannula patency compared to continuous infusion for peripherally inserted venous catheters in newborns: results from a prospective observational study
  22. Opinion Paper
  23. Cross-over training in neonatology and obstetrics
  24. Congress Calender
  25. Congress Calendar
  26. Masthead
  27. Masthead
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