Association between increased yolk sac diameter and abnormal karyotypes
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Ksenija Gersak
,
Alenka Veble
Abstract
Aims: To investigate the association between increased yolk sac diameter and abnormal karyotype.
Methods: Retrospective analysis of 42 patients with no history of diabetes between 6 and 12 weeks of gestation with increased yolk sac diameter measuring ≥6mm was evaluated by transvaginal ultrasound. Sonographic findings were correlated with karyotype. The Fisher’s exact test and exact conditional logistic regression analysis were used for statistical analysis.
Results: Chromosome abnormalities were found in 76.2% of chorionic villi samples. A statistically significant relationship between karyotype and missed abortion was detected (P=0.001). None of the patients with a yolk size diameter ≥8mm and viable pregnancy had a normal karyotype. Trisomy 15 or 16 was strongly associated with missed abortion (unadjusted odds ratio=14.97, P=0.01). Nine patients with viable pregnancy had a yolk sac ≥6mm (six patients with normal karyotype, one patient with monosomy X, one patient with trisomy 16, and one patient with trisomy 21).
Conclusion: Our data indicate that enlarged yolk sac may also be visualized in viable pregnancies. Patients with an enlarged yolk sac and normal karyotype require detailed ultrasound evaluation in the second and third trimester.
©2012 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Review Article
- Retinal microvascular changes in low-birth-weight babies have a link to future health
- Original Articles – Obstetrics
- Chromosomal mosaicisms in prenatal diagnosis: correlation with first trimester screening and clinical outcome
- Perinatal impact of the use of metformin and glyburide for the treatment of gestational diabetes mellitus
- Incidence and causes of maternal thrombocytopenia in triplet gestation
- Maternal and paternal age and twinning in the United States, 2004–2008
- Correlates of the trend of cesarean section rates in twin pregnancies
- Prospective risk of stillbirth: monochorionic diamniotic twins vs. dichorionic twins
- Association between increased yolk sac diameter and abnormal karyotypes
- No “masculinization” effect of a male on birth weight of its female co-twin
- Comparison of risk calculation approaches in a screening programme for Down syndrome
- Individual decisions in placenta increta and percreta: a case series
- Original Articles – Fetus
- Fetal sex and perinatal outcomes
- Fetal magnetocardiography (fMCG): moving forward in the establishment of clinical reference data by advanced biomagnetic instrumentation and analysis
- Maternal and fetal cord blood lipids in intrauterine growth restriction
- Assessment of long-axis ventricular function in the fetal heart with a tissue-tracking algorithm
- Original Articles – Newborn
- A cluster of methicillin-sensitive Staphylococcus aureus colonization in a nursery
- Intermittent flushing improves cannula patency compared to continuous infusion for peripherally inserted venous catheters in newborns: results from a prospective observational study
- Opinion Paper
- Cross-over training in neonatology and obstetrics
- Congress Calender
- Congress Calendar
- Masthead
- Masthead
