Effects of Vitamin D Receptor Gene Polymorphisms on Susceptibility to Disease and Bone Mineral Density in Turkish Patients with Type 1 Diabetes Mellitus
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A. Kocabaş
ABSTRACT
Background: Vitamin D receptor (VDR) gene is regarded as one of the candidate genes for type 1 diabetes mellitus (T1D) susceptibility and of some genetic factors involved in the development of osteoporosis in this group.
Study design: We characterized the VDR gene polymorphism (BsmI, ApaI, TaqI, FokI and Cdx-2 binding site) in a group of Turkish patients with T1D (n=90) and correlated respective VDR genotypes with the bone mass and some parameters of bone turnover.
Results: There were no differences in the genotype frequencies of the BsmI, ApaI, TaqI and Cdx-2 polymorphisms in patients and control subjects. We found a significantly higher prevalence of the F allele/the FF genotype in the patients compared to controls (p=0,0031, odds 1.96 (1,27-3,01)). We observed no difference in markers of bone turnover (Serum levels of osteocalcin, PINP and alkaline phosphatase, urinary levels of calcium/creatinine and N-telopeptid) among different VDR genotypes. No correlation was found between VDR polymorphisms and DEXA measurements of these patients.
Conclusions: Although the FF genotype was found to be a risk factor in a Turkish population, elucidation of this result is necessary in other larger study groups drawn from the same ethnic population.
© Freund Publishing House Ltd. 2010
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- Congenital Adrenal Hyperplasia (CAH) a Wolf in a Rabbits' Fur
- Endogenous Hyperandrogenism and Exercise Capacity Lessons from the Exercise-Congenital Adrenal Hyperplasia Model
- A Child with Cushing's Syndrome – Etiological Clue from Adrenal Imaging (Pediatric Cushing's Syndrome)
- Polycystic Ovaries and Adrenal Insufficiency in a Young Pubescent Female with Lipoid Congenital Adrenal Hyperplasia Due to Splice Mutation of the StAR Gene: A Case Report and Review of the Literature
- Does Fat Fuel the Fire: Independent and Interactive Effects of Genetic, Physiological, and Environmental Factors on Variations in Fat Deposition and Distribution across Populations
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