Stress hyperglycemia in pediatric patients as a risk factor for type 1 diabetes – a single center experience
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Giora Weiser
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Yitshak Yaniv
Abstract
Objectives
Stress hyperglycemia is relatively common in the pediatric emergency department. It is usually associated with severe illnesses such as infections, seizures, and trauma. The association between stress hyperglycemia and future development of type 1 diabetes mellitus is unclear. Different reports have shown controversial results.
Methods
This was a retrospective follow-up cohort of children admitted to the pediatric emergency department at the Shaare Zedek Medical Center in Jerusalem, Israel during the years 2010–2014 with stress hyperglycemia. The study group was then evaluated over a 10-year period for developing type 1 diabetes mellitus. The study group incidence was then compared to the general population.
Results
During the study period, there were 1,184 admissions with stress hyperglycemia. The most common diagnoses were infectious (36.5 %) and respiratory (24.3 %) diseases. There were two cases that later developed type 1 diabetes. This resulted in an odds ratio of 14.95 for developing type 1 diabetes in the study cohort (with fatalities removed) compared to the known incidence in Israel at that time (95 % CI, (p<0.01)).
Conclusions
Children presenting with stress hyperglycemia may be at greater risk for developing type 1 diabetes and should warrant close follow-up and possibly advanced testing to offer early diagnosis.
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Research ethics: This study was approved by the Institutional Review Board (Helsinki) with waiver of informed consent as it is anonymized. SZMC-22-0084 (2022).
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Informed consent: Not applicable.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Conflict of interest: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.
References
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© 2025 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Mini Review
- Transition of care from childhood/adolescence to adulthood in familial hypercholesterolemia
- Original Articles
- Performance of adult height prediction methods in 6 to 8-year-old girls with GnRH-dependent precocious puberty
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- Endocrinopathies associated with pediatric common variable immunodeficiency
- Genetic, neuroimaging, and clinical characteristics of a cohort of individuals with L-2-hydroxyglutaric aciduria from Türkiye
- Short Communications
- Stress hyperglycemia in pediatric patients as a risk factor for type 1 diabetes – a single center experience
- Observations of the effect of gonadotropin-releasing hormone analog treatment on psychosocial well-being in transgender youth and their caregivers – a pilot study
- Letter to the Editor
- GNB1 haploinsufficiency presents as monogenic obesity syndrome
- Case Reports
- Rare pediatric insulinoma case diagnosed by endoscopic ultrasonography: insights into endogenous hyperinsulinemic hypoglycemia
- Caudal epidural steroid injection as a novel therapy for treatment-induced neuropathy of diabetes in children: report of two cases
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Artikel in diesem Heft
- Frontmatter
- Mini Review
- Transition of care from childhood/adolescence to adulthood in familial hypercholesterolemia
- Original Articles
- Performance of adult height prediction methods in 6 to 8-year-old girls with GnRH-dependent precocious puberty
- Height velocity in the detection of growth disorders reconsidered: a retrospective analysis of the DONALD study
- Differentiating transient and permanent congenital hypothyroidism: predictive clues from Istanbul, Türkiye
- Evaluation of thyrotrophic and lactotrophic reserves in patients with pituitary dwarfism with and without empty sella turcica
- Exploring the impact of androgen levels on depression and anxiety in adolescent females: a clinical perspective
- The diagnostic value of stimulated androgen ratios in 5-alpha reductase type 2 (SRD5A2) deficiency: a case series and review of the literature
- Prolonged symptom duration and the potential for gradual progression in pediatric adrenocortical tumors: observations from the MET studies
- Distinguishing organic from idiopathic central precocious puberty: clinical characteristics and predictive factors for organic etiology in a multicenter Italian cohort study
- Endocrinopathies associated with pediatric common variable immunodeficiency
- Genetic, neuroimaging, and clinical characteristics of a cohort of individuals with L-2-hydroxyglutaric aciduria from Türkiye
- Short Communications
- Stress hyperglycemia in pediatric patients as a risk factor for type 1 diabetes – a single center experience
- Observations of the effect of gonadotropin-releasing hormone analog treatment on psychosocial well-being in transgender youth and their caregivers – a pilot study
- Letter to the Editor
- GNB1 haploinsufficiency presents as monogenic obesity syndrome
- Case Reports
- Rare pediatric insulinoma case diagnosed by endoscopic ultrasonography: insights into endogenous hyperinsulinemic hypoglycemia
- Caudal epidural steroid injection as a novel therapy for treatment-induced neuropathy of diabetes in children: report of two cases
- A novel homozygous missense DNAJC3 variant in syndromic juvenile-onset diabetes
- 3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency: case report of a child with rare HMGCL gene variants
