Differentiating transient and permanent congenital hypothyroidism: predictive clues from Istanbul, Türkiye
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Ceren Ulusoy
,
Heves Kırmızıbekmez
und
Fatma Dursun
Abstract
Objectives
Congenital hypothyroidism (CH) requires early diagnosis to prevent irreversible neurodevelopmental impairments. This study aimed to determine cutoff values for initial capillary thyroid-stimulating hormone (TSH), first venous TSH, and levothyroxine (LT4) dose at 6 months to differentiate between transient and permanent CH.
Methods
A retrospective analysis was conducted on 289 patients diagnosed with CH at the Pediatric Endocrinology Clinic of the University of Health Sciences, Umraniye Training and Research Hospital, from January 2014 to September 2021. Patients received treatment and were followed for at least 6 months after treatment discontinuation or remained under therapy. Patients were divided into two groups: permanent CH and transient CH. Initial capillary TSH, first venous TSH, and LT4 dose at 6 months were recorded, and cutoff values were determined using ROC analysis.
Results
Of the 289 patients, 179 (62 %) had transient CH and 110 (38 %) had permanent CH. The permanent CH group had significantly higher levels of capillary TSH, first venous TSH, and LT4 dose at 6 months (p<0.001). The cutoff values for predicting transient CH were <23.1 mIU/L for capillary TSH, <64.5 mIU/L for first venous TSH, and <3.6 µg/kg/day for LT4 dose at 6 months, all statistically significant.
Conclusions
Initial capillary TSH, first venous TSH, and LT4 dose at 6 months are reliable predictors for distinguishing between transient and permanent CH. These cutoff values provide clinical guidance, especially for early treatment discontinuation in patients with LT4 doses below 3.6 µg/kg/day, indicating a higher likelihood of transient CH.
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Research ethics: Ethical approval for the study was obtained from the Ethics Committee of the University of Health Sciences Ümraniye Training and Research Hospital, on March 31, 2022 (Approval No: B.10.1.THK.4.34.H.GP.0.01/105).
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Informed consent: Not applicable.
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Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: In preparing this manuscript, we did not used large language models, artificial intelligence, or machine learning tools.
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Conflict of interest: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: The authors have decided not to disclose any data.
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© 2025 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Mini Review
- Transition of care from childhood/adolescence to adulthood in familial hypercholesterolemia
- Original Articles
- Performance of adult height prediction methods in 6 to 8-year-old girls with GnRH-dependent precocious puberty
- Height velocity in the detection of growth disorders reconsidered: a retrospective analysis of the DONALD study
- Differentiating transient and permanent congenital hypothyroidism: predictive clues from Istanbul, Türkiye
- Evaluation of thyrotrophic and lactotrophic reserves in patients with pituitary dwarfism with and without empty sella turcica
- Exploring the impact of androgen levels on depression and anxiety in adolescent females: a clinical perspective
- The diagnostic value of stimulated androgen ratios in 5-alpha reductase type 2 (SRD5A2) deficiency: a case series and review of the literature
- Prolonged symptom duration and the potential for gradual progression in pediatric adrenocortical tumors: observations from the MET studies
- Distinguishing organic from idiopathic central precocious puberty: clinical characteristics and predictive factors for organic etiology in a multicenter Italian cohort study
- Endocrinopathies associated with pediatric common variable immunodeficiency
- Genetic, neuroimaging, and clinical characteristics of a cohort of individuals with L-2-hydroxyglutaric aciduria from Türkiye
- Short Communications
- Stress hyperglycemia in pediatric patients as a risk factor for type 1 diabetes – a single center experience
- Observations of the effect of gonadotropin-releasing hormone analog treatment on psychosocial well-being in transgender youth and their caregivers – a pilot study
- Letter to the Editor
- GNB1 haploinsufficiency presents as monogenic obesity syndrome
- Case Reports
- Rare pediatric insulinoma case diagnosed by endoscopic ultrasonography: insights into endogenous hyperinsulinemic hypoglycemia
- Caudal epidural steroid injection as a novel therapy for treatment-induced neuropathy of diabetes in children: report of two cases
- A novel homozygous missense DNAJC3 variant in syndromic juvenile-onset diabetes
- 3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency: case report of a child with rare HMGCL gene variants
Artikel in diesem Heft
- Frontmatter
- Mini Review
- Transition of care from childhood/adolescence to adulthood in familial hypercholesterolemia
- Original Articles
- Performance of adult height prediction methods in 6 to 8-year-old girls with GnRH-dependent precocious puberty
- Height velocity in the detection of growth disorders reconsidered: a retrospective analysis of the DONALD study
- Differentiating transient and permanent congenital hypothyroidism: predictive clues from Istanbul, Türkiye
- Evaluation of thyrotrophic and lactotrophic reserves in patients with pituitary dwarfism with and without empty sella turcica
- Exploring the impact of androgen levels on depression and anxiety in adolescent females: a clinical perspective
- The diagnostic value of stimulated androgen ratios in 5-alpha reductase type 2 (SRD5A2) deficiency: a case series and review of the literature
- Prolonged symptom duration and the potential for gradual progression in pediatric adrenocortical tumors: observations from the MET studies
- Distinguishing organic from idiopathic central precocious puberty: clinical characteristics and predictive factors for organic etiology in a multicenter Italian cohort study
- Endocrinopathies associated with pediatric common variable immunodeficiency
- Genetic, neuroimaging, and clinical characteristics of a cohort of individuals with L-2-hydroxyglutaric aciduria from Türkiye
- Short Communications
- Stress hyperglycemia in pediatric patients as a risk factor for type 1 diabetes – a single center experience
- Observations of the effect of gonadotropin-releasing hormone analog treatment on psychosocial well-being in transgender youth and their caregivers – a pilot study
- Letter to the Editor
- GNB1 haploinsufficiency presents as monogenic obesity syndrome
- Case Reports
- Rare pediatric insulinoma case diagnosed by endoscopic ultrasonography: insights into endogenous hyperinsulinemic hypoglycemia
- Caudal epidural steroid injection as a novel therapy for treatment-induced neuropathy of diabetes in children: report of two cases
- A novel homozygous missense DNAJC3 variant in syndromic juvenile-onset diabetes
- 3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency: case report of a child with rare HMGCL gene variants
