The diagnostic utility of bioelectrical impedance analysis in distinguishing precocious puberty from premature thelarche
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Serkan Bilge Koca
,
Tarık Kırkgöz
und
Leyla Kara
Abstract
Objectives
Clinical (assessing breast development), laboratory (FSH, LH, estradiol, and GnRH stimulation test), and radiological methods (bone age and pelvic ultrasonography) are used to distinguish central precocious puberty (CPP) from premature thelarche (PT). We examined also via bioelectrical impedance analysis (BIA).
Methods
The fat mass (FM), fat-free mass (FFM), muscle mass (MM), bone mass (BM), total body water, and percentages (%), basal metabolic rate, phase angle (PhA), muscle-to-fat ratio (MFR), sarcopenic index, and segmental body proportions were determined via Tanita MC-780 MA model measuring device.
Results
A total of 111 girls, 34 with CPP, 35 with PT, and 42 with healthy controls, were included. Although the baseline weight, height, and BMI SDS of the groups were not statistically different, the FM (%) was found to be lower (p=0.021), and the FFM (%) (p=0.021), MM (%) (p=0.015), BM (%) (p=0.022), and MFR values (p=0.017) were higher in CPP group. In CPP group, right arm FM (%) (p=0.016), left arm FM (%) (p=0.007), and trunk FM (%) (p=0.008) were lower than other groups.
Conclusions
We detected a MFR cutoff value of (2.96) with 58.8 % sensitivity and 58.4 % specificity, a cutoff value of (3.57) with 50 % sensitivity and 82 % specificity to differentiate CPP cases from others (PT and healthy controls). These rates are relatively low, but these are the first results in this field and may be guiding for studies conducted in large series.
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Research ethics: The local Institutional Review Board approved the study.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Use of Large Language Models, AI and Machine Learning Tools: None declared.
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Conflict of interest: The authors state no conflict of interest.
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Research funding: None declared.
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Data availability: Not applicable.
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© 2025 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Reviews
- Pubertal disorders in juvenile idiopathic arthritis: a systemic review
- Hormonal therapy for impaired growth due to pediatric-onset inflammatory bowel disease: a systematic review and meta-analysis with trial sequential analysis
- Mini Review
- Neonatal hypoglycaemia in the offsprings of parents with maturity-onset diabetes of the young (MODY)
- Original Articles
- Cord blood metabolomic profiling in high risk newborns born to diabetic, obese, and overweight mothers: preliminary report
- Impact of Covid-19 on children and adolescents with type 1 diabetes: lifestyle, telecommunication service, and quality of life
- The diagnostic utility of bioelectrical impedance analysis in distinguishing precocious puberty from premature thelarche
- Infant gonadotropins predict spontaneous puberty in girls with Turner syndrome
- Bioinformatics analysis explores key pathways and hub genes in central precocious puberty
- Impact of growth hormone therapy on bone and body composition in prepubertal children with idiopathic short stature
- Presence of hyperandrogenemia in cases evaluated due to menstrual irregularity, the effect of clinical and/or biochemical hyperandrogenemia on polycystic ovary syndrome
- Cardiac function in children with congenital adrenal hyperplasia
- Short Communication
- Clinical and genetic insights into congenital lipoid adrenal hyperplasia: a case series from a tertiary care center in North India
- Case Reports
- Two families, two pathways: a case series of 46, XY DSD with 17α-hydroxylase deficiency and isolated 17,20-lyase deficiency due to novel CYB5A variant
- Coexistence of SRY, DHX37 and POR gene variants in a patient with 46,XY disorder of sex development
- Diabetes, macrocytosis, and skin changes in large-scale mtDNA deletion
Artikel in diesem Heft
- Frontmatter
- Reviews
- Pubertal disorders in juvenile idiopathic arthritis: a systemic review
- Hormonal therapy for impaired growth due to pediatric-onset inflammatory bowel disease: a systematic review and meta-analysis with trial sequential analysis
- Mini Review
- Neonatal hypoglycaemia in the offsprings of parents with maturity-onset diabetes of the young (MODY)
- Original Articles
- Cord blood metabolomic profiling in high risk newborns born to diabetic, obese, and overweight mothers: preliminary report
- Impact of Covid-19 on children and adolescents with type 1 diabetes: lifestyle, telecommunication service, and quality of life
- The diagnostic utility of bioelectrical impedance analysis in distinguishing precocious puberty from premature thelarche
- Infant gonadotropins predict spontaneous puberty in girls with Turner syndrome
- Bioinformatics analysis explores key pathways and hub genes in central precocious puberty
- Impact of growth hormone therapy on bone and body composition in prepubertal children with idiopathic short stature
- Presence of hyperandrogenemia in cases evaluated due to menstrual irregularity, the effect of clinical and/or biochemical hyperandrogenemia on polycystic ovary syndrome
- Cardiac function in children with congenital adrenal hyperplasia
- Short Communication
- Clinical and genetic insights into congenital lipoid adrenal hyperplasia: a case series from a tertiary care center in North India
- Case Reports
- Two families, two pathways: a case series of 46, XY DSD with 17α-hydroxylase deficiency and isolated 17,20-lyase deficiency due to novel CYB5A variant
- Coexistence of SRY, DHX37 and POR gene variants in a patient with 46,XY disorder of sex development
- Diabetes, macrocytosis, and skin changes in large-scale mtDNA deletion
