Predictive factors for lung metastasis in pediatric differentiated thyroid cancer: a clinical prediction study
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Hou-fang Kuang
Abstract
Objectives
The objective of this study was to develop and evaluate the efficacy of a nomogram for predicting lung metastasis in pediatric differentiated thyroid cancer.
Methods
The SEER database was utilized to collect a dataset consisting of 1,590 patients who were diagnosed between January 2000 and December 2019. This dataset was subsequently utilized for the purpose of constructing a predictive model. The model was constructed utilizing a multivariate logistic regression analysis, incorporating a combination of least absolute shrinkage feature selection and selection operator regression models. The differentiation and calibration of the model were assessed using the C-index, calibration plot, and ROC curve analysis, respectively. Internal validation was performed using a bootstrap validation technique.
Results
The results of the study revealed that the nomogram incorporated several predictive variables, namely age, T staging, and positive nodes. The C-index had an excellent calibration value of 0.911 (95 % confidence interval: 0.876–0.946), and a notable C-index value of 0.884 was achieved during interval validation. The area under the ROC curve was determined to be 0.890, indicating its practicality and usefulness in this context.
Conclusions
This study has successfully developed a novel nomogram for predicting lung metastasis in children and adolescent patients diagnosed with thyroid cancer. Clinical decision-making can be enhanced by assessing clinicopathological variables that have a significant predictive value for the probability of lung metastasis in this particular population.
Funding source: Maternal and Child Health Hospital Foundation
Award Identifier / Grant number: 220936007
Acknowledgments
We thank all members of our study team for their wholehearted cooperation.
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Research ethics: Not applicable.
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Informed consent: Not applicable.
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Author contributions: All authors contributed to study design and manuscript writing. Houfang Kuang undertook the research, wrote the main manuscript text, and prepared figures. Wenliang Lu revised the article critically for important intellectual content and final approval of the version to be submitted. All authors reviewed the manuscript.
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Competing interests: The authors state no conflict of interest.
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Research funding: This study was financially support by the foundation from Maternal and Child Health Hospital Foundation (No. 220936007 and No. 220936010).
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Data availability: The study data are from SEER database (https://seer.cancer.gov/).
References
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Supplementary Material
This article contains supplementary material (https://doi.org/10.1515/jpem-2023-0425).
© 2024 Walter de Gruyter GmbH, Berlin/Boston
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Articles in the same Issue
- Frontmatter
- Editorial
- Insulin for “hearts that had lost hope” – on the first pediatric patients and the 1923 Nobel Prize in Physiology or Medicine
- Reviews
- The effect of gonadotropin-releasing hormone analog treatment on the endocrine system in central precocious puberty patients: a meta-analysis
- Artificial intelligence in paediatric endocrinology: conflict or cooperation
- Original Articles
- A pilot study proposing an algorithm for pubertal induction in cerebral palsy
- Thyroid volume in Turkish school-age children living in an iodine-sufficient region
- Hypothyroxinemia and weight velocity in preterm infants
- Factors associated with neonatal hyperinsulinemic hypoglycemia, a case-control study
- Predictive factors for lung metastasis in pediatric differentiated thyroid cancer: a clinical prediction study
- Case Reports
- Two Turkish patients with Primary Coenzyme Q10 Deficiency-7: case report and literature review
- Hereditary spastic paraplegia type 35 in a Turkish girl with fatty acid hydroxylase-associated neurodegeneration
- A case report of odonto-hypophosphatasia with a novel variant in the ALPL gene
- Neuronal ceroid lipofuscinosis type 11 diagnosed patient with bi-allelic variants in GRN gene: case report and review of literature
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