Peripheral arterial disease among children with type 1 diabetes mellitus in a Nigerian teaching hospital
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Gbenga Akinyosoye
,
Ibironke Jadesola Akinola
,
Amotunur Bukola Lamina
Abstract
Objectives
The study aimed to determine the prevalence of PAD in children with T1DM and to correlate PAD with clinical characteristics in children with T1DM.
Methods
A comparative cross-sectional study was conducted involving 90 subjects (forty-five with T1DM and 45 apparently healthy comparative subjects that were matched for age and gender). Systolic blood pressure was measured in all limbs using the pocket Doppler machine (Norton Doppler scan machine). Ankle brachial index (ABI) was calculated as a ratio of ankle to arm systolic blood pressure. Peripheral arterial disease was defined as ABI less than 0.9.
Results
The prevalence of PAD was significantly higher in children with T1DM than in the matched comparison group (37.8% vs. 6.7%, p<0.001). Average values of waist circumference, hip circumference, weight, height and body mass index were comparable in subjects with TIDM and the comparison group (p>0.05). Subjects with PAD had a poorer glucose control evident by higher average values of glycated haemoglobin than those without PAD (13.47 ± 3.2% vs. 8.16 ± 2.3%, p<0.001). There is a strong negative correlation between ABI scores and glycated haemoglobin among subjects with T1DM (r=−0.626, p<0.001).
Conclusions
With these findings, it is recommended that screening for PAD in children who have T1DM and poor glycaemic control should be done early to prevent cardiovascular complications before they arise.
Acknowledgments
The authors appreciate Drs Akanmu Wasiu and Lawan Olaide for their help with sample collection.
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Research funding: None declared.
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Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: Authors state no conflict of interest.
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Informed consent: Informed consent was obtained from all individuals included in this study.
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Ethical approval: Approval was granted by the Health and Research Ethics committee of LASUTH with approval number LREC/06/10/1871.
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Articles in the same Issue
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- Congenital hypothyroidism in children with eutopic gland or thyroid hemiagenesis: prognostic factors for transient vs. permanent hypothyroidism
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- Impact of overweight and obesity on epicardial adipose tissue in children with type 1 diabetes
- Peripheral arterial disease among children with type 1 diabetes mellitus in a Nigerian teaching hospital
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- Clinical correlation of 2D shear wave elastography findings in children with type 1 diabetes mellitus without autoimmune thyroiditis
- Molecular analysis of MKRN3 gene in Turkish girls with sporadic and familial idiopathic central precocious puberty
- Case Reports
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Articles in the same Issue
- Frontmatter
- Reviews
- Approach to nutritional rickets
- Subclinical hyperthyroidism in children
- Original Articles
- Can thyroid elastography with ultrasound be used to stage children with Hashimoto’s thyroiditis?
- Congenital hypothyroidism in children with eutopic gland or thyroid hemiagenesis: prognostic factors for transient vs. permanent hypothyroidism
- Comparison of developmental outcomes in children with permanent and transient congenital hypothyroidism
- Impact of overweight and obesity on epicardial adipose tissue in children with type 1 diabetes
- Peripheral arterial disease among children with type 1 diabetes mellitus in a Nigerian teaching hospital
- The WHO-5 well-being questionnaire in type 1 diabetes: screening for depression in pediatric and young adult subjects
- Clinical correlation of 2D shear wave elastography findings in children with type 1 diabetes mellitus without autoimmune thyroiditis
- Molecular analysis of MKRN3 gene in Turkish girls with sporadic and familial idiopathic central precocious puberty
- Case Reports
- ALG11-CDG: novel variant and review of the literature
- Betamethasone cream to treat diapers rash causing Cushing syndrome
- Rapid-onset obesity, hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome – neuro-endocrine tumours (ROHHAD-NET): case series and learning points
- Lathosterolosis: a rare cholesterol metabolism disorder with a wide range of clinical variability
- Urea as safe treatment for hyponatremia due to syndrome of inappropriate antidiuretic hormone in infant with solitary central incisor and neurofibromatosis-1
