Ethnic diversity and burden of polycystic ovary syndrome among US adolescent females

Jaclyn Khil; Jeanne A. Darbinian; Lynn Guo; Louise C. Greenspan; Nirmala D. Ramalingam; Joan C. Lo

doi:10.1515/jpem-2022-0160

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Ethnic diversity and burden of polycystic ovary syndrome among US adolescent females

Jaclyn Khil , Jeanne A. Darbinian , Lynn Guo , Louise C. Greenspan , Nirmala D. Ramalingam und Joan C. Lo

Veröffentlicht/Copyright: 23. Mai 2022

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Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 35 Heft 6

Abstract

Objectives

Polycystic Ovary Syndrome (PCOS) is a common female endocrine disorder presenting as early as adolescence. Recent data suggest that Asians may be at increased risk. This study examines PCOS prevalence by race/ethnicity in a large, diverse population of adolescent females.

Methods

This retrospective study included 244,642 females (ages 13–17) with well-child visits during 2012–2018 in a Northern California healthcare system. Race/ethnicity and Asian ethnicity were classified using self-reported data. Body mass index was classified as healthy, overweight, and moderate/severe obesity. PCOS was determined by clinical diagnosis within one year of the visit.

Results

The overall prevalence of PCOS was 0.7% and increased substantially with weight. Among those with obesity, PCOS prevalence was 4.2, 2.9, 2.4, 2.1% in Asian/Pacific Islander (PI), Hispanic/Latina, Non-Hispanic White, Black adolescents and 7.8, 6.7, 5.7, 3.4% in South Asian, Chinese, Filipina, Native Hawaiian/PI adolescents, respectively. Compared to White adolescents, Asian/PIs had two-fold higher risk of PCOS, and Hispanic/Latinas had 1.3-fold higher risk. Compared to Chinese adolescents, South Asians had 1.7-fold higher risk, while Native Hawaiian/PIs had half the risk.

Conclusions

The increased burden of diagnosed PCOS in Asian/PI and Hispanic/Latina adolescents, especially those with obesity, calls for further examination and clinical surveillance of at-risk populations.

Keywords: BMI; female sex; obesity; PCOS; pediatric; weight

Joan C. Lo, MD, Research Scientist, Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA, USA; The Permanente Medical Group, Oakland, CA, USA; and Graduate Medical Education, Kaiser Permanente Oakland Medical Center, Oakland, CA, USA, Phone: 510 891 3492, Fax: 510 891 3508, E-mail: Joan.C.Lo@kp.org

Funding source: Kaiser Permanente Northern California Community Health Program

Research funding: This study was funded by Graduate Medical Education Research, which receives support from the Kaiser Permanente Community Health Program.
Author contributions: Jaclyn Khil, Joan Lo, Jeanne Darbinian, Nirmala Ramalingam, and Louise Greenspan conceived and designed the study; Jeanne Darbinian obtained the data, conducted the data analyses, and interpreted the data; Jaclyn Khil, Joan Lo, Lynn Guo, and Louise Greenspan conducted the literature review and interpreted the data; Jaclyn Khil, Joan Lo, Jeanne Darbinian, and Lynn Guo wrote the initial draft of the manuscript. All authors reviewed and edited the manuscript for important intellectual content. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: A waiver of informed consent was obtained due to the nature of the study.
Ethical approval: The study was approved by the Kaiser Permanente Northern California Institutional Review Board (KPNC IRB) with a waiver of informed consent. The study was subsequently reviewed by the KPNC IRB under the Revised Common Rule criteria and met Exempt Category 4iii under 45 CFR 46.104(d).

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Received: 2022-04-01

Accepted: 2022-04-11

Published Online: 2022-05-23

Published in Print: 2022-06-27

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https://doi.org/10.1515/jpem-2022-0160

Schlagwörter für diesen Artikel

BMI; female sex; obesity; PCOS; pediatric; weight