Startseite Genomic landscape of sporadic pediatric differentiated thyroid cancers: a systematic review and meta-analysis
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Genomic landscape of sporadic pediatric differentiated thyroid cancers: a systematic review and meta-analysis

  • Swayamjeet Satapathy und Chandrasekhar Bal EMAIL logo
Veröffentlicht/Copyright: 18. April 2022
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 35 Heft 6

Abstract

Objectives

Differentiated thyroid cancers (DTCs) in the paediatric population differ from that of their adult counterparts in terms of clinicopathological characteristics and treatment outcomes. This systematic review and meta-analysis was conducted to comprehensively evaluate the prevalence of various genetic alterations underlying the pathogenesis of sporadic paediatric DTCs.

Methods

This study followed the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) guidelines. Systematic searches were made on the PubMed and Embase databases using relevant keywords, and articles published until October 15, 2021 were selected. Data on the prevalence of various genetic alterations were extracted from the individual articles. Random-effects model was employed for meta-analysis to generate pooled estimates and their 95% confidence intervals (95% CIs).

Results

Thirty-three articles comprising 1,380 paediatric patients were included. RET rearrangement (pooled prevalence: 24.4%, 95% CI: 19.1–30.1) was observed to be the most common genetic alteration in sporadic paediatric DTCs, closely followed by BRAF point mutation (pooled prevalence: 21.2%, 95% CI: 17.2–25.5). Other common alterations included: NTRK rearrangement (pooled prevalence: 13.5%, 95% CI: 9.5–17.9) and DICER1 mutation (pooled prevalence: 12.5%, 95% CI: 3.6–25.7). RAS and TERT mutations were observed to be relatively uncommon (pooled prevalence: 5.7%, 95% CI: 2.9–9.3, and 2.2%, 95% CI: 0.4–5.5, respectively). There was no evidence of publication bias.

Conclusions

Fusion oncogenes are noted to be the major oncogenic drivers in sporadic paediatric DTCs and underlie their unique behaviour. However, despite the relatively lower frequency of BRAF point mutation compared to adults, it remains a major player in childhood DTCs.

Keywords: fusion oncogene; meta-analysis; mutation; paediatric thyroid cancer; rearrangement; systematic review
Corresponding author: Chandrasekhar Bal, MD, DSc, Professor and Head, Department of Nuclear Medicine, All India Institute of Medical Sciences, Ansari Nagar, 110029, New Delhi, India, Phone: +91 9013775659, E-mail:

  1. Research funding: None declared.

  2. Author contributions: Swayamjeet Satapathy: Literature search, article selection, data extraction, statistical analysis, manuscript writing. Chandrasekhar Bal: Conception, literature search, article selection, data extraction, statistical analysis, interpretation, manuscript refinement, and final approval.

  3. Competing interests: None declared.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/jpem-2021-0741).

Received: 2021-12-09
Accepted: 2022-03-28
Published Online: 2022-04-18
Published in Print: 2022-06-27

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

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  2. Review Articles
  3. The genetic elucidation of monogenic obesity in the Arab world: a systematic review
  4. Global perspective on pediatric growth hormone registries: a systematic review
  5. Mini Review
  6. Considering metformin as a second-line treatment for children and adolescents with prediabetes
  7. Original Articles
  8. Central adrenal insufficiency screening with morning plasma cortisol and ACTH levels in Prader–Willi syndrome
  9. Clinical characteristics and genetics analysis for the ITD of congenital hypothyroidism
  10. Genomic landscape of sporadic pediatric differentiated thyroid cancers: a systematic review and meta-analysis
  11. The role of circulating miRNAs in leptin resistance in obese children
  12. Relationship between height age, bone age and chronological age in normal children in the context of nutritional and pubertal status
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  17. Glycemic control among children with type 1 diabetes mellitus and its determinants in a resource-limited setting
  18. Letter to the Editor
  19. Anxiety, pediatric type 1 diabetes and COVID-19 lockdown
  20. Short Communication
  21. Ethnic diversity and burden of polycystic ovary syndrome among US adolescent females
  22. Case Reports
  23. Feminizing adrenocortical oncocytoma presenting as precocious puberty: a case report and literature review
  24. Novel OTX2 loss of function variant associated with congenital hypopituitarism without eye abnormalities
  25. Bilateral Wilms’ tumor in a child with Denys-Drash syndrome: novel frameshift variant disrupts the WT1 nuclear location signaling region
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https://doi.org/10.1515/jpem-2021-0741
Schlagwörter für diesen Artikel
fusion oncogene; meta-analysis; mutation; paediatric thyroid cancer; rearrangement; systematic review

Artikel in diesem Heft

  1. Frontmatter
  2. Review Articles
  3. The genetic elucidation of monogenic obesity in the Arab world: a systematic review
  4. Global perspective on pediatric growth hormone registries: a systematic review
  5. Mini Review
  6. Considering metformin as a second-line treatment for children and adolescents with prediabetes
  7. Original Articles
  8. Central adrenal insufficiency screening with morning plasma cortisol and ACTH levels in Prader–Willi syndrome
  9. Clinical characteristics and genetics analysis for the ITD of congenital hypothyroidism
  10. Genomic landscape of sporadic pediatric differentiated thyroid cancers: a systematic review and meta-analysis
  11. The role of circulating miRNAs in leptin resistance in obese children
  12. Relationship between height age, bone age and chronological age in normal children in the context of nutritional and pubertal status
  13. Clinical, biochemical, and biomolecular aspects of congenital adrenal hyperplasia in a group of Cameroonian children and adolescents
  14. Ten year analysis of the clinic profile of the tertiary paediatric endocrine service in Western Australia
  15. Postoperative intensive care management and residual endocrinopathy of pediatric supratentorial brain tumors: a retrospective cohort study
  16. Successful telehealth transformation of a pediatric outpatient obesity teaching program due to the COVID-19 pandemic – the “Video KiCK” program
  17. Glycemic control among children with type 1 diabetes mellitus and its determinants in a resource-limited setting
  18. Letter to the Editor
  19. Anxiety, pediatric type 1 diabetes and COVID-19 lockdown
  20. Short Communication
  21. Ethnic diversity and burden of polycystic ovary syndrome among US adolescent females
  22. Case Reports
  23. Feminizing adrenocortical oncocytoma presenting as precocious puberty: a case report and literature review
  24. Novel OTX2 loss of function variant associated with congenital hypopituitarism without eye abnormalities
  25. Bilateral Wilms’ tumor in a child with Denys-Drash syndrome: novel frameshift variant disrupts the WT1 nuclear location signaling region
  26. A very rare cause of arthrogryposis multiplex congenita: a novel mutation in TOR1A
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