Glycated hemoglobin A1c as a screening test for detecting type 2 diabetes mellitus in obese children and adolescents
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Jong Seo Yoon
Abstract
Background:
The diagnostic cutoff points for indicators of type 2 diabetes mellitus (T2DM) in the pediatric population have not been defined thus far.
Methods:
A retrospective, single-center study was conducted from April 2003 to May 2016. We enrolled 236 overweight or obese children and adolescents aged 4–17 years. Thirty-nine (26.9%) of 145 patients had T2DM according to the oral glucose tolerance test results.
Results:
A glycated hemoglobin (HbA1c) level of 6.5% had a sensitivity and specificity of 87.2% and 98.5%, respectively, for detecting T2DM. The optimal HbA1c cutoff level for T2DM was >6.2% (94.7% sensitivity, 95.5% specificity).
Conclusions:
We observed that the use of an HbA1c level of 6.5% had a lower sensitivity for detecting T2DM than an HbA1c level of >6.2%.
Author contributions: J.S. Yoon conceptualized and designed the study, enrolled the subjects, carried out the initial analysis and drafted the initial manuscript; C.H. So conceptualized and designed the study, carried out the initial statistical analysis and reviewed and revised the manuscript; H.S. Lee conceptualized and designed the study, coordinated and supervised data collection and critically reviewed the manuscript; J.S. Hwang made a substantial contribution to the concept and design, acquisition of data, analysis and interpretation of data and reviewed and critically revised important intellectual content. All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2018 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Review
- Review and evaluation of patient-centered psychosocial assessments for children with central precocious puberty or early puberty
- Mini Review
- Childhood obesity: how long should we wait to predict weight?
- Original Articles
- Glycated hemoglobin A1c as a screening test for detecting type 2 diabetes mellitus in obese children and adolescents
- Effect of a multidisciplinary treatment program on eating behavior in overweight and obese preschool children
- Cord blood klotho levels are inversely associated with leptin in healthy Latino neonates at risk for obesity
- Still too little, too late? Ten years of growth hormone therapy baseline data from the NordiNet® International Outcome Study
- Body composition and metabolic health of young male adults with childhood-onset multiple pituitary hormone deficiency after cessation of growth hormone treatment
- Hematuria as an adverse outcome following provocative growth hormone stimulation testing in children
- Bone mineral density comparison of adolescents with constitutional thinness and anorexia nervosa
- Adult height in patients with familial male-limited precocious puberty and the role of an aromatase inhibitor in patient management
- Association between UCP polymorphisms and adipokines with obesity in Mexican adolescents
- Impact of childhood type 1 diabetes on maternal work-family relations
- Case Reports
- Hyperthyroidism in an infant of a mother with autoimmune hypothyroidism with positive TSH receptor antibodies
- Sanjad-Sakati syndrome with macrocytic anemia and failure to thrive: a case from South Jordan
- In iodine-induced thyrotoxicosis, steroid therapy today could keep the surgical knife at bay
- Graves’ disease following allogenic hematopoietic stem cell transplantation for severe aplastic anemia: case report and literature review
Artikel in diesem Heft
- Frontmatter
- Review
- Review and evaluation of patient-centered psychosocial assessments for children with central precocious puberty or early puberty
- Mini Review
- Childhood obesity: how long should we wait to predict weight?
- Original Articles
- Glycated hemoglobin A1c as a screening test for detecting type 2 diabetes mellitus in obese children and adolescents
- Effect of a multidisciplinary treatment program on eating behavior in overweight and obese preschool children
- Cord blood klotho levels are inversely associated with leptin in healthy Latino neonates at risk for obesity
- Still too little, too late? Ten years of growth hormone therapy baseline data from the NordiNet® International Outcome Study
- Body composition and metabolic health of young male adults with childhood-onset multiple pituitary hormone deficiency after cessation of growth hormone treatment
- Hematuria as an adverse outcome following provocative growth hormone stimulation testing in children
- Bone mineral density comparison of adolescents with constitutional thinness and anorexia nervosa
- Adult height in patients with familial male-limited precocious puberty and the role of an aromatase inhibitor in patient management
- Association between UCP polymorphisms and adipokines with obesity in Mexican adolescents
- Impact of childhood type 1 diabetes on maternal work-family relations
- Case Reports
- Hyperthyroidism in an infant of a mother with autoimmune hypothyroidism with positive TSH receptor antibodies
- Sanjad-Sakati syndrome with macrocytic anemia and failure to thrive: a case from South Jordan
- In iodine-induced thyrotoxicosis, steroid therapy today could keep the surgical knife at bay
- Graves’ disease following allogenic hematopoietic stem cell transplantation for severe aplastic anemia: case report and literature review
