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Markers influencing the presence of partial clinical remission in patients with newly diagnosed type 1 diabetes

  • Aleksandra Pyziak , Agnieszka Zmyslowska ORCID logo , Katarzyna Bobeff , Beata Malachowska , Wojciech Fendler , Krystyna Wyka , Anna Baranowska-Jazwiecka , Malgorzata Szymanska , Agnieszka Szadkowska and Wojciech Mlynarski EMAIL logo
Published/Copyright: October 10, 2017
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 30 Issue 11

Abstract

Background:

The aim of the study was to compare the selected markers in children with and without partial clinical remission (CR) of newly diagnosed type 1 diabetes (T1D).

Methods:

The study group consisted of 186 patients (F/M; 87/99) at onset of T1D and 24 months of follow-up. Partial CR was defined as insulin requirement <0.5 IU/kg and glycated hemoglobin (HbA1c) <7%.

Results:

Partial CR was observed in 115/186 (61.83%) of patients. At diagnosis body mass index standard deviation (BMI SDS) was higher among remitters than in non-remitters (p=0.0051) and remitters were younger (p=0.0029). In the follow-up a higher triglyceride concentration in non-remitters compared to remitters (p=0.0455) and a lower high density lipoprotein (HDL) cholesterol level (p=0.0119) were noticed.

Conclusions:

Younger age and higher BMI at diagnosis of T1D can predispose to partial CR in children. In patients with CR of T1D after 2 years of follow-up a lipid profile improvement is observed.

Keywords: BMI; clinical remission; lipids; type 1 diabetes
Corresponding author: Wojciech Mlynarski, MD, PhD, Department of Paediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz, Sporna Str. 36/50, 91-738, Lodz, Poland, Phone: +48 42 6177750, Fax: +48 42 6177798
aAleksandra Pyziak and Agnieszka Zmyslowska contributed equally to this work.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Supplemental Material:

The online version of this article offers supplementary material (https://doi.org/10.1515/jpem-2017-0100).

Received: 2017-3-6
Accepted: 2017-8-28
Published Online: 2017-10-10
Published in Print: 2017-10-26

©2017 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Mini Review
  3. Severe complications after initial management of hyperglycemic hyperosmolar syndrome and diabetic ketoacidosis with a standard diabetic ketoacidosis protocol
  4. Original Articles
  5. Markers influencing the presence of partial clinical remission in patients with newly diagnosed type 1 diabetes
  6. Oral health status of children with type 1 diabetes: a comparative study
  7. The relationship between non-alcoholic fatty liver disease and small intestinal bacterial overgrowth among overweight and obese children and adolescents
  8. High attainment of optimal nutritional and growth status observed among Greek pediatric cystic fibrosis patients: results from the GreeCF study
  9. Secular trends in height, weight and body mass index of primary school children in Turkey between 1993 and 2016
  10. Effects of 1-year growth hormone replacement therapy on thyroid volume and function of the children and adolescents with idiopathic growth hormone deficiency
  11. Thyroid hormone levels in late preterm, early term and term infants: a study with healthy neonates revealing reference values and factors affecting thyroid hormones
  12. Makorin ring finger 3 gene analysis in Koreans with familial precocious puberty
  13. Genetic analysis of fructose-1,6-bisphosphatase (FBPase) deficiency in nine consanguineous Pakistani families
  14. Reassessing the significance of the PAH c.158G>A (p.Arg53His) variant in patients with hyperphenylalaninemia
  15. Case Reports
  16. Sirolimus precipitating diabetes mellitus in a patient with congenital hyperinsulinaemic hypoglycaemia due to autosomal dominant ABCC8 mutation
  17. Persistent de Quervain tenosynovitis induced by somatotropin treatment
  18. Early-onset severe obesity due to complete deletion of the leptin gene in a boy
  19. Congenital cataract with LSS gene mutations: a new case report
https://doi.org/10.1515/jpem-2017-0100
Keywords for this article
BMI; clinical remission; lipids; type 1 diabetes

Articles in the same Issue

  1. Frontmatter
  2. Mini Review
  3. Severe complications after initial management of hyperglycemic hyperosmolar syndrome and diabetic ketoacidosis with a standard diabetic ketoacidosis protocol
  4. Original Articles
  5. Markers influencing the presence of partial clinical remission in patients with newly diagnosed type 1 diabetes
  6. Oral health status of children with type 1 diabetes: a comparative study
  7. The relationship between non-alcoholic fatty liver disease and small intestinal bacterial overgrowth among overweight and obese children and adolescents
  8. High attainment of optimal nutritional and growth status observed among Greek pediatric cystic fibrosis patients: results from the GreeCF study
  9. Secular trends in height, weight and body mass index of primary school children in Turkey between 1993 and 2016
  10. Effects of 1-year growth hormone replacement therapy on thyroid volume and function of the children and adolescents with idiopathic growth hormone deficiency
  11. Thyroid hormone levels in late preterm, early term and term infants: a study with healthy neonates revealing reference values and factors affecting thyroid hormones
  12. Makorin ring finger 3 gene analysis in Koreans with familial precocious puberty
  13. Genetic analysis of fructose-1,6-bisphosphatase (FBPase) deficiency in nine consanguineous Pakistani families
  14. Reassessing the significance of the PAH c.158G>A (p.Arg53His) variant in patients with hyperphenylalaninemia
  15. Case Reports
  16. Sirolimus precipitating diabetes mellitus in a patient with congenital hyperinsulinaemic hypoglycaemia due to autosomal dominant ABCC8 mutation
  17. Persistent de Quervain tenosynovitis induced by somatotropin treatment
  18. Early-onset severe obesity due to complete deletion of the leptin gene in a boy
  19. Congenital cataract with LSS gene mutations: a new case report
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