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High attainment of optimal nutritional and growth status observed among Greek pediatric cystic fibrosis patients: results from the GreeCF study

  • Dimitrios Poulimeneas ORCID logo EMAIL logo , Argiri Petrocheilou , Maria G. Grammatikopoulou , Athanasios G. Kaditis , Ioanna Loukou , Stavros E. Doudounakis , Dimitrios Laggas and Tonia Vassilakou EMAIL logo
Published/Copyright: October 31, 2017
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 30 Issue 11

Abstract

Background:

Pediatric cystic fibrosis (CF) patients suffer high rates of undernutrition, subject to several parameters. We aimed to assess growth and nutritional status of Greek children and adolescents with CF.

Methods:

Eighty-four patients (35 boys) formed the sample. Anthropometrics and FEV1 were measured, growth and weight status were assessed. Body mass index (BMI), arm circumference (MUAC), fat (MUAFA) and muscle (MUAMA) were calculated.

Results:

In the total sample, 6.0% of the patients were underweight, 4.8% stunted, 8.3% wasted and 17.9% in nutritional failure, whereas 59.5% attained the ideal BMI for CF. FEV1 positively associated with BMI (B=0.03, p≤0.003), weight (B=0.03, p≤0.003) and MUAMA z-scores (B=0.04, p≤0.005). Meconium ileus negatively associated with FEV1 (B=−14.17, p≤0.003) and stature (B=−0.65, p≤0.043). Pancreatic insufficiency negatively influenced MUAC and MUAFA z-scores (p≤0.05 for both).

Conclusions:

The examined CF patients appear to be thriving. Unlike published research, the participants’ sex, gene mutation and acquisition of pathogens did not affect growth.

Keywords: cystic fibrosis; growth; lung function; nutritional failure; underweight
Corresponding authors: Dr. Tonia Vassilakou, Department of Nutrition and Biochemistry, National School of Public Health, 196 Alexandras Avenue, 11521, Athens, Greece, Phone: +30213-2010288

Acknowledgments

The authors wish to express their gratitude to Ms. Eugenia Troupi for her organizational and managerial support during the study, Mr. Kimonas Sfiggos for his help with locating patient files, as well as the patients and their guardians for participating in the study.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2017-1-9
Accepted: 2017-9-25
Published Online: 2017-10-31
Published in Print: 2017-10-26

©2017 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Mini Review
  3. Severe complications after initial management of hyperglycemic hyperosmolar syndrome and diabetic ketoacidosis with a standard diabetic ketoacidosis protocol
  4. Original Articles
  5. Markers influencing the presence of partial clinical remission in patients with newly diagnosed type 1 diabetes
  6. Oral health status of children with type 1 diabetes: a comparative study
  7. The relationship between non-alcoholic fatty liver disease and small intestinal bacterial overgrowth among overweight and obese children and adolescents
  8. High attainment of optimal nutritional and growth status observed among Greek pediatric cystic fibrosis patients: results from the GreeCF study
  9. Secular trends in height, weight and body mass index of primary school children in Turkey between 1993 and 2016
  10. Effects of 1-year growth hormone replacement therapy on thyroid volume and function of the children and adolescents with idiopathic growth hormone deficiency
  11. Thyroid hormone levels in late preterm, early term and term infants: a study with healthy neonates revealing reference values and factors affecting thyroid hormones
  12. Makorin ring finger 3 gene analysis in Koreans with familial precocious puberty
  13. Genetic analysis of fructose-1,6-bisphosphatase (FBPase) deficiency in nine consanguineous Pakistani families
  14. Reassessing the significance of the PAH c.158G>A (p.Arg53His) variant in patients with hyperphenylalaninemia
  15. Case Reports
  16. Sirolimus precipitating diabetes mellitus in a patient with congenital hyperinsulinaemic hypoglycaemia due to autosomal dominant ABCC8 mutation
  17. Persistent de Quervain tenosynovitis induced by somatotropin treatment
  18. Early-onset severe obesity due to complete deletion of the leptin gene in a boy
  19. Congenital cataract with LSS gene mutations: a new case report
https://doi.org/10.1515/jpem-2017-0013
Keywords for this article
cystic fibrosis; growth; lung function; nutritional failure; underweight

Articles in the same Issue

  1. Frontmatter
  2. Mini Review
  3. Severe complications after initial management of hyperglycemic hyperosmolar syndrome and diabetic ketoacidosis with a standard diabetic ketoacidosis protocol
  4. Original Articles
  5. Markers influencing the presence of partial clinical remission in patients with newly diagnosed type 1 diabetes
  6. Oral health status of children with type 1 diabetes: a comparative study
  7. The relationship between non-alcoholic fatty liver disease and small intestinal bacterial overgrowth among overweight and obese children and adolescents
  8. High attainment of optimal nutritional and growth status observed among Greek pediatric cystic fibrosis patients: results from the GreeCF study
  9. Secular trends in height, weight and body mass index of primary school children in Turkey between 1993 and 2016
  10. Effects of 1-year growth hormone replacement therapy on thyroid volume and function of the children and adolescents with idiopathic growth hormone deficiency
  11. Thyroid hormone levels in late preterm, early term and term infants: a study with healthy neonates revealing reference values and factors affecting thyroid hormones
  12. Makorin ring finger 3 gene analysis in Koreans with familial precocious puberty
  13. Genetic analysis of fructose-1,6-bisphosphatase (FBPase) deficiency in nine consanguineous Pakistani families
  14. Reassessing the significance of the PAH c.158G>A (p.Arg53His) variant in patients with hyperphenylalaninemia
  15. Case Reports
  16. Sirolimus precipitating diabetes mellitus in a patient with congenital hyperinsulinaemic hypoglycaemia due to autosomal dominant ABCC8 mutation
  17. Persistent de Quervain tenosynovitis induced by somatotropin treatment
  18. Early-onset severe obesity due to complete deletion of the leptin gene in a boy
  19. Congenital cataract with LSS gene mutations: a new case report
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