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Fetal goitrous hypothyroidism treated by intra-amniotic levothyroxine administration: case report and review of the literature

  • Mami Kobayashi EMAIL logo , Hideaki Yagasaki , Tomohiro Saito , Atsushi Nemoto , Atsushi Naito and Kanji Sugita
Published/Copyright: August 3, 2017
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 30 Issue 9

Abstract

Background:

Fetal goitrous hypothyroidism is mainly caused by maternal treatment of Graves’ disease. Fetal goiter sometimes compresses the trachea and esophagus and may cause polyhydramnios, preterm labor, complications of labor and delivery, and neonatal respiratory disorder.

Case presentation:

We report a case of fetal goitrous hypothyroidism in which the mother had Graves’ disease, which was treated with propylthiouracil. Intra-amniotic levothyroxine (L-T4) administration was performed, and the fetal goiter decreased in size. A female infant was delivered without goiter and complications. Thyroid function was within the normal range.

Conclusions:

Previous reports on fetal goitrous hypothyroidism that was treated with intra-amniotic L-T4 showed that patients who had intra-amniotic L-T4 administration were likely to have a good outcome compared with patients who did not have L-T4. Thyroid function of the mother and fetus should be carefully monitored and treated appropriately.

Keywords: fetal goiter; intra-amniotic levothyroxine administration; maternal Graves’ disease
Corresponding author: Mami Kobayashi, PhD, Department of Neonatology, Yamanashi Prefectural Central Hospital, 1-1-1 Fujimi, Kofu, Yamanashi 400-8506, Japan, Phone: +8155-253-7111, Fax: +8155-253-8011

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2017-2-28
Accepted: 2017-7-3
Published Online: 2017-8-3
Published in Print: 2017-8-28

©2017 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. Standard body mass index reference data of prepubescent diabetic Egyptian children
  4. Frequency and risk factors of depression in type 1 diabetes in a developing country
  5. Association of obesity and health related quality of life in Iranian children and adolescents: the Weight Disorders Survey of the CASPIAN-IV study
  6. Association between urinary phthalates and metabolic abnormalities in obese Thai children and adolescents
  7. A pilot study of the effect of human breast milk on urinary metabolome analysis in infants
  8. Assessment of the correlation between the atherogenic index of plasma and cardiometabolic risk factors in children and adolescents: might it be superior to the TG/HDL-C ratio?
  9. Cardiovascular and metabolic risk in pediatric patients with congenital adrenal hyperplasia due to 21 hydroxylase deficiency
  10. Application of povidone-iodine at delivery significantly increases maternal urinary iodine but not neonatal thyrotropin in an area with iodine sufficiency
  11. Influence of topical iodine-containing antiseptics used during delivery on recall rate of congenital hypothyroidism screening program
  12. Applying targeted next generation sequencing to dried blood spot specimens from suspicious cases identified by tandem mass spectrometry-based newborn screening
  13. Short Communication
  14. Initial patient choice of a growth hormone device improves child and adolescent adherence to and therapeutic effects of growth hormone replacement therapy
  15. Case Reports
  16. An occult ectopic parathyroid adenoma in a pediatric patient: a case report and management algorithm
  17. Fetal goitrous hypothyroidism treated by intra-amniotic levothyroxine administration: case report and review of the literature
  18. Carotid intima media thickness in a girl with sitosterolemia carrying a homozygous mutation in the ABCG5 gene
  19. Sirolimus in the treatment of three infants with diffuse congenital hyperinsulinism
https://doi.org/10.1515/jpem-2017-0094
Keywords for this article
fetal goiter; intra-amniotic levothyroxine administration; maternal Graves’ disease

Articles in the same Issue

  1. Frontmatter
  2. Original Articles
  3. Standard body mass index reference data of prepubescent diabetic Egyptian children
  4. Frequency and risk factors of depression in type 1 diabetes in a developing country
  5. Association of obesity and health related quality of life in Iranian children and adolescents: the Weight Disorders Survey of the CASPIAN-IV study
  6. Association between urinary phthalates and metabolic abnormalities in obese Thai children and adolescents
  7. A pilot study of the effect of human breast milk on urinary metabolome analysis in infants
  8. Assessment of the correlation between the atherogenic index of plasma and cardiometabolic risk factors in children and adolescents: might it be superior to the TG/HDL-C ratio?
  9. Cardiovascular and metabolic risk in pediatric patients with congenital adrenal hyperplasia due to 21 hydroxylase deficiency
  10. Application of povidone-iodine at delivery significantly increases maternal urinary iodine but not neonatal thyrotropin in an area with iodine sufficiency
  11. Influence of topical iodine-containing antiseptics used during delivery on recall rate of congenital hypothyroidism screening program
  12. Applying targeted next generation sequencing to dried blood spot specimens from suspicious cases identified by tandem mass spectrometry-based newborn screening
  13. Short Communication
  14. Initial patient choice of a growth hormone device improves child and adolescent adherence to and therapeutic effects of growth hormone replacement therapy
  15. Case Reports
  16. An occult ectopic parathyroid adenoma in a pediatric patient: a case report and management algorithm
  17. Fetal goitrous hypothyroidism treated by intra-amniotic levothyroxine administration: case report and review of the literature
  18. Carotid intima media thickness in a girl with sitosterolemia carrying a homozygous mutation in the ABCG5 gene
  19. Sirolimus in the treatment of three infants with diffuse congenital hyperinsulinism
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