Neck circumference is similarly predicting for impairment of glucose tolerance as classic anthropometric parameters among healthy and obese children and adolescents
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Jennifer Junge
Abstract
Background:
The objective of the study was to investigate the association of neck circumference (NC) to parameters of glucose homeostasis compared to classical anthropometric parameters of lean and obese children.
Methods:
Three dimensional (3D)-body scanning quantified anthropometric (height, weight, NC, hip/waist circumference, BMI) and metabolic parameters (fasting plasma glucose [FPG], insulin, HbA1c, oGTT, HOMA-IR) were determined cross-sectionally in 1542 participants (5–18 years).
Results:
NC was positively correlated with all metabolic parameters, except for FPG. For HbA1c there was only a modestly positive correlation. The associations between NC and glucose parameters were rather weak, while the correlation to insulin parameters were stronger. Overall the strongest association to glucose metabolism parameters was found for waist circumference (WC), except for FPG and 2h-postload glucose. In multiple linear regression analyses, NC provided additional benefit beyond classical anthropometric indices to describe impairment of glucose homeostasis.
Conclusions:
We suggest that NC is comparable or additive to established anthropometric parameters but might not be superior to them. However NC is simple to measure, reproducible and may be considered in clinical practice as an additional measurement tool.
Author contributions: Jennifer Junge: design of the study, statistical analyses, interpretation of data, discussion of results, writing of the manuscript; Christoph Engel: statistical analyses, interpretation of data, critical revision of article; Stephanie Naumann: acquisition of data; Mandy Vogel: data preparation, data preprocessing, data quality; Markus Löffler: conception of 3D-body scanner evaluation; Jürgen Kratzsch: laboratory analyses, critical reading of the manuscript, interpretation of data; Joachim Thiery conception of the study; Wieland Kiess: conception and design of the study, discussion of article, critical revision of article; Antje Körner: interpretation of data, discussion of results, critical revision of article. All authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: The LIFE child study is funded by means of the European Union, by the European Regional Development Fund (ERDF) and by means of the Free State of Saxony within the framework of the excellence initiative for the period 2009–2013. Other official funds from the German Research Foundation (DFG) and the Federal Ministry of Education and Research (BMBF) have been obtained for sub-projects related to intermediate outcomes. Additional funding is being obtained continuously.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Review
- Multiple effects of probiotics on different types of diabetes: a systematic review and meta-analysis of randomized, placebo-controlled trials
- Original Articles
- Oral administration of diluted nasal desmopressin in managing neonatal central diabetes insipidus
- Does body fat percentage predict post-exercise heart rate response in non-obese children and adolescents?
- The relationship between insulin resistance and endothelial dysfunction in obese adolescents
- Neck circumference is similarly predicting for impairment of glucose tolerance as classic anthropometric parameters among healthy and obese children and adolescents
- Reduced bone mineral density in Chinese children with phenylketonuria
- Assessment of stress levels in girls with central precocious puberty before and during long-acting gonadotropin-releasing hormone agonist treatment: a pilot study
- Association study of LIN28B in girls with precocious puberty
- Molecular genetics of growth hormone deficient children: correlation with auxology and response to first year of growth hormone therapy
- Evaluation of factors associated with elevated newborn 17-hydroxyprogesterone levels
- Evaluation of endocrine and metabolic dysfunctions after hematopoietic stem cell transplantation in children: a study from Turkey
- Case Reports
- Opioid-induced hyponatremia in a patient with central diabetes insipidus: independence from ADH
- Deoxyguanosine kinase deficiency: a report of four patients
- Fructose-1,6-bisphosphatase deficiency caused by a novel homozygous Alu element insertion in the FBP1 gene and delayed diagnosis
Artikel in diesem Heft
- Frontmatter
- Review
- Multiple effects of probiotics on different types of diabetes: a systematic review and meta-analysis of randomized, placebo-controlled trials
- Original Articles
- Oral administration of diluted nasal desmopressin in managing neonatal central diabetes insipidus
- Does body fat percentage predict post-exercise heart rate response in non-obese children and adolescents?
- The relationship between insulin resistance and endothelial dysfunction in obese adolescents
- Neck circumference is similarly predicting for impairment of glucose tolerance as classic anthropometric parameters among healthy and obese children and adolescents
- Reduced bone mineral density in Chinese children with phenylketonuria
- Assessment of stress levels in girls with central precocious puberty before and during long-acting gonadotropin-releasing hormone agonist treatment: a pilot study
- Association study of LIN28B in girls with precocious puberty
- Molecular genetics of growth hormone deficient children: correlation with auxology and response to first year of growth hormone therapy
- Evaluation of factors associated with elevated newborn 17-hydroxyprogesterone levels
- Evaluation of endocrine and metabolic dysfunctions after hematopoietic stem cell transplantation in children: a study from Turkey
- Case Reports
- Opioid-induced hyponatremia in a patient with central diabetes insipidus: independence from ADH
- Deoxyguanosine kinase deficiency: a report of four patients
- Fructose-1,6-bisphosphatase deficiency caused by a novel homozygous Alu element insertion in the FBP1 gene and delayed diagnosis
