Startseite Vitamin D status in Egyptian children with type 1 diabetes and the role of vitamin D replacement in glycemic control
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Vitamin D status in Egyptian children with type 1 diabetes and the role of vitamin D replacement in glycemic control

  • Mona Hafez , Mona Hassan , Noha Musa EMAIL logo , Sahar Abdel Atty und Sally Abdel Azim
Veröffentlicht/Copyright: 20. Dezember 2016
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 30 Heft 4

Abstract

Background:

The association of low serum 25 hydroxy cholecalciferol (25OHD) levels with high glucose level and diminished insulin sensitivity suggests that vitamin D (VD) may modulate insulin metabolism. The aim of the study was to screen for vitamin D deficiency (VDD) in pediatric patients with type 1 diabetes (T1D) and study the effect of VD supplementation on their glycemic control and insulin requirements.

Methods:

A prospective cohort study including 50 patients with T1D. VD level was assessed initially and after 3 months of VD supplementation (in those with VDD). HbA1c and insulin requirements were studied at 0, 3 and 6 months of supplementation.

Results:

Fifty patients with T1D were included with mean diabetes duration of 4.11±2.34 years. VD level ranged from 0.2 to 33 ng/mL. VD status correlated significantly with daily insulin dose (p=0.030, r=0.306) and HbA1c (p<0.001, r=0.243). Thirty-five patients (70%) had VDD and were allocated for VD supplementation for 3 months. The mean HbA1c improved significantly after supplementation (p=0.003), followed by a significant deterioration at 6 months with no change in their insulin requirements at 3 or 6 months.

Conclusions:

VD was highly prevalent in Egyptian T1D patients. VD supplementation improved glycemic control at 3 months after therapy with no reduction in insulin requirements.

Keywords: glycemic control; type 1 diabetes; 25OHD; vitamin D supplementation

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. Mona Hafez and Mona Hassan set the study design. Sally Abdel Azim and Noha Musa recruited the patients, collected the samples and supplemented the patients with vitamin D. Sahar Sharaf performed the laboratory assessment. Sally Abdel Azim collected and tabulated the data. Noha Musa, Mona Hafez and Mona Hassan wrote the paper.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2016-7-20
Accepted: 2016-11-3
Published Online: 2016-12-20
Published in Print: 2017-4-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Pediatric endocrinology is pediatrics is public health
  4. Original Articles
  5. Total body fat, abdominal fat, body fat distribution and surrogate markers for health related to adipocyte fatty acid-binding protein (FABP4) in children
  6. Vitamin D supplementation, the metabolic syndrome and oxidative stress in obese children
  7. Vitamin D status in Egyptian children with type 1 diabetes and the role of vitamin D replacement in glycemic control
  8. Cross-sectional analysis of universal vitamin D supplementation in former East Germany during the first year of life
  9. Ethnicity and incidence of congenital hypothyroidism in the capital of Macedonia
  10. Changes of thyroid hormonal status in patients receiving ketogenic diet due to intractable epilepsy
  11. Leptin and adiponectin levels in discordant dichorionic twins at 72 hours of age-associations with anthropometric parameters and insulin resistance
  12. Analysis of growth hormone receptor gene expression in tall and short stature children
  13. Clinical features of girls with short stature among inv (9), Turner (45, X) and control individuals
  14. Hereditary vitamin D-resistant rickets in Lebanese patients: the p.R391S and p.H397P variants have different phenotypes
  15. Associations between obesity, adverse behavioral patterns and cardiovascular risk factors among adolescent inhabitants of a Greek island
  16. Increase of body mass index (BMI) from 1.5 to 3 years of age augments the degree of insulin resistance corresponding to BMI at 12 years of age
  17. Case Reports
  18. The variable clinical phenotype of three patients with hepatic glycogen synthase deficiency
  19. Molecular defects identified by whole exome sequencing in a child with atypical mucopolysaccharidosis IIIB
  20. Clinical presentation and treatment response to diazoxide in two siblings with congenital hyperinsulinism as a result of a novel compound heterozygous ABCC8 missense mutation
  21. Cushing’s syndrome in infancy due to ectopic ACTH secretion by a sacro-coccygeal teratoma
  22. Letters to the Editor
  23. Growth-hormone deficiency in mitochondrial disorders
  24. Response to Growth hormone deficiency in mitochondrial disorders
https://doi.org/10.1515/jpem-2016-0292
Schlagwörter für diesen Artikel
glycemic control; type 1 diabetes; 25OHD; vitamin D supplementation

Artikel in diesem Heft

  1. Frontmatter
  2. Editorial
  3. Pediatric endocrinology is pediatrics is public health
  4. Original Articles
  5. Total body fat, abdominal fat, body fat distribution and surrogate markers for health related to adipocyte fatty acid-binding protein (FABP4) in children
  6. Vitamin D supplementation, the metabolic syndrome and oxidative stress in obese children
  7. Vitamin D status in Egyptian children with type 1 diabetes and the role of vitamin D replacement in glycemic control
  8. Cross-sectional analysis of universal vitamin D supplementation in former East Germany during the first year of life
  9. Ethnicity and incidence of congenital hypothyroidism in the capital of Macedonia
  10. Changes of thyroid hormonal status in patients receiving ketogenic diet due to intractable epilepsy
  11. Leptin and adiponectin levels in discordant dichorionic twins at 72 hours of age-associations with anthropometric parameters and insulin resistance
  12. Analysis of growth hormone receptor gene expression in tall and short stature children
  13. Clinical features of girls with short stature among inv (9), Turner (45, X) and control individuals
  14. Hereditary vitamin D-resistant rickets in Lebanese patients: the p.R391S and p.H397P variants have different phenotypes
  15. Associations between obesity, adverse behavioral patterns and cardiovascular risk factors among adolescent inhabitants of a Greek island
  16. Increase of body mass index (BMI) from 1.5 to 3 years of age augments the degree of insulin resistance corresponding to BMI at 12 years of age
  17. Case Reports
  18. The variable clinical phenotype of three patients with hepatic glycogen synthase deficiency
  19. Molecular defects identified by whole exome sequencing in a child with atypical mucopolysaccharidosis IIIB
  20. Clinical presentation and treatment response to diazoxide in two siblings with congenital hyperinsulinism as a result of a novel compound heterozygous ABCC8 missense mutation
  21. Cushing’s syndrome in infancy due to ectopic ACTH secretion by a sacro-coccygeal teratoma
  22. Letters to the Editor
  23. Growth-hormone deficiency in mitochondrial disorders
  24. Response to Growth hormone deficiency in mitochondrial disorders
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