Abstract
Diabetic ketoacidosis (DKA) is a complex metabolic state characterized by hyperglycemia, metabolic acidosis and ketonuria. Cerebral edema is the most common rare complication of DKA in children. The objective of the study was to emphasize the importance of careful evaluation and monitoring for signs and symptoms of cerebral edema in all children undergoing treatment for DKA. We present a case of 11-year-old girl with a history of diabetes mellitus type I (T1DM) who presented with severe DKA complicated by hypovolemic shock, cerebral edema and hematemesis. Considering the fact that complications of DKA are rare and require a high index of clinical suspicion, early recognition and treatment are crucial for avoiding permanent damage.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Raghupathy P. Diabetic ketoacidosis in children and adolescents. Indian J Endocrinol Metab 2015;19(Suppl 1):S55–7.10.4103/2230-8210.155403Search in Google Scholar PubMed PubMed Central
2. Tahirovic H, Toromanovic A, Drop D, Hasanovic E. Ketoacidosis at onset of type 1 diabetes mellitus in children and Bosnia and Herzegovina: frequency and clinical presentation. J Clin Endocrinol Metab 2007;20:1137–40.10.1515/JPEM.2007.20.10.1137Search in Google Scholar PubMed
3. Wolfsdorf J, Glaser N, Sperling MA; American Diabetes Association. Diabetic ketoacidosis in infants, children, and adolescents: a consensus statement from the American Diabetes Association. Diabetes Care 2006;29:1150–9.10.2337/dc06-9909Search in Google Scholar
4. Dunger DB, Sperling MA, Acerini CL, Bohn DJ, Daneman D, et al. European Society for Paediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society consensus statement on diabetic ketoacidosis in children and adolescents. Pediatrics 2004;113:e133–40.10.1542/peds.113.2.e133Search in Google Scholar PubMed
5. Cebeci AN, Guven A, Kirmizibekmez H, Yildiz M, Dursun F. Clinical features and management of diabetic ketoacidosis in different age groups of children: children less than 5 years of age are at higher risk of metabolic decompensation. J Pediatr Endocrinol Metab 2012;25:917–25.10.1515/jpem-2012-0110Search in Google Scholar PubMed
6. Glaser NS, Ghetti S, Casper TC, Dean JM, Kuppermann N, et al. Pediatric diabetic ketoacidosis, fluid therapy and cerebral injury: the design of a factorial randomized controlled trial. Pediatr Diabetes 2013;12:513–7.10.1111/pedi.12027Search in Google Scholar PubMed PubMed Central
7. Krane EJ, Rockoff MA, Wallman JK, Wolfsdorf JI. Subclinical brain swelling in children during treatment of diabetic ketoacidosis. N Engl J Med 1985;312:1147–51.10.1056/NEJM198505023121803Search in Google Scholar PubMed
8. Hoffman WH, Steinhart CM, el Gammal T, Steele S, Cuadrado AR, et al. Cranial CT in children and adolescents with diabetic ketoacidosis. AJNR Am J Neuroradiol 1988;9:733–9.Search in Google Scholar
9. Edge JA, Hawkins MM, Winter DL, Dunger DB. The risk and outcome of cerebral oedema developing during diabetic ketoacidosis. Arch Dis Child 2001;85:16–22.10.1136/adc.85.1.16Search in Google Scholar PubMed PubMed Central
10. Marcin JP, Glaser N, Barnett P, McCaslin I, Nelson D, et al. Factors associated with adverse outcomes in children with diabetic ketoacidosis-related cerebral edema. J Pediatr 2002;141:793–7.10.1067/mpd.2002.128888Search in Google Scholar PubMed
11. Glaser N, Barnett P, McCaslin I, Nelson D, Traino J, et al. Risk factors for cerebral edema in children with diabetic ketoacidosis. The Pediatric Emergency Medicine Collaborative Research Committee of the American Academy of Pediatrics. N Engl J Med 2001;344:264–9.10.1056/NEJM200101253440404Search in Google Scholar PubMed
12. Lawrence SE, Cummings EA, Gaboury I, Daneman D. Population-based study of incidence and risk factors for cerebral edema in pediatric diabetic ketoacidosis. J Pediatr 2005;146:688–92.10.1016/j.jpeds.2004.12.041Search in Google Scholar
13. Bureau MA, Bégin R, Berthiaume Y, Shapcott D, Khoury K, et al. Cerebral hypoxia from bicarbonate infusion in diabetic acidosis. J Pediatr 1980;96:968–73.10.1016/S0022-3476(80)80619-6Search in Google Scholar
14. Edge JA, Jakes RW, Roy Y, Hawkins M, Winter D, et al. The UK case-control study of cerebral oedema complicating diabetic ketoacidosis in children. Diabetologia 2006;49:2002–9.10.1007/s00125-006-0363-8Search in Google Scholar
15. Bialo SR, Agrawal S, Boney CM, Quintos JB. Rare complications of pediatric diabetic ketoacidosis. World J Diabetes 2015;6: 167–74.10.4239/wjd.v6.i1.167Search in Google Scholar
16. Hoorn EJ, Carlotti AP, Costa LA, MacMahon B, Bohn G, et al. Preventing a drop in effective plasma osmolality to minimize the likelihood of cerebral edema during treatment of children with diabetic ketoacidosis. J Pediatr 2007;150:467–73.10.1016/j.jpeds.2006.11.062Search in Google Scholar
17. Petzold S, Kapellen T, Siekmeyer M, Hirsch W, Bartelt H, et al. Acute cerebral infatction and extra pontine myelinolysis in children with new onset type 1 diabetes mellitus. Pediatr Diabetes 2011;12:513–17.10.1111/j.1399-5448.2010.00732.xSearch in Google Scholar
18. Mahoney CP, Vlcek BW, DelAguila M. Risk factors for developing brain herniation during diabetic ketoacidosis. Pediatr Neurol 1999;21:721–7.10.1016/S0887-8994(99)00079-XSearch in Google Scholar
19. Glaser N. Cerebral injury and cerebral edema in children with diabetic ketoacidosis: could cerebral ischemia and reperfusion injury be involved? Pediatr Diabetes 2009;10:534–41.10.1111/j.1399-5448.2009.00511.xSearch in Google Scholar PubMed
20. Glaser NS, Wootton-Gorges SL, Buonocore MH, Tancredi DJ, Marcin JP, et al. Subclinical cerebral edema in children with diabetic ketoacidosis randomized to 2 different rehydration protocols. Pediatrics 2013;131:73–80.10.1542/peds.2012-1049Search in Google Scholar PubMed PubMed Central
21. Muir AB, Quisling RG, Yang MC, Rosenbloom AL. Cerebral edema in childhood diabetic ketoacidosis: natural history, radiographic findings, and early identification. Diabetes Care 2004;27: 1541–6.10.2337/diacare.27.7.1541Search in Google Scholar PubMed
22. Wolfsdorf JI. The International Society of Pediatric and Adolescent Diabetes guidelines for management of diabetic ketoacidosis: do the guidelines need to be modified? Pediatr Diabetes 2014;15:277–86.10.1111/pedi.12154Search in Google Scholar PubMed
23. Franklin B, Liu J, Ginsberg-Fellner F. Cerebral edema and ophthalmoplegia reversed by mannitol in a new case of insulin-dependent diabetes mellitus. Pediatrics 1982;69:87–90.10.1542/peds.69.1.87Search in Google Scholar
24. Kamat P, Vats A, Gross M, Checchia PA. Use of hypertonic saline for the treatment of altered mental status associated with diabetic ketoacidosis. Pediatr Crit Care Med 2003;4:239–42.10.1097/01.PCC.0000059340.19010.CESearch in Google Scholar PubMed
25. Güven A, Hancili S, Karatoprak EY, Tasel B. Symptomatic cerebral infarction in a child with severe diabetic ketoacidosis. J Pediatr Endocr Met 2014;27:1001–4.10.1515/jpem-2014-0037Search in Google Scholar PubMed
26. Mulder L, Onur O, Kleis L, Borders H, Cemeroglu AP. Atypical neurologic presentations of new onset type 1 diabetes mellitus in pediatric age group: a report of five unusual cases and review of the literature. J Pediatr Endocrinol Metab 2014;27:749–56.10.1515/jpem-2013-0312Search in Google Scholar PubMed
27. Yaroglu Kazanci S, Yesilbas O, Ersoy M, Kihtir HS, Yildirim HM, et al. Cerebral infarction and femoral venous thrombosis detected in a patient with diabetic ketoacidosis and heterozygous factor V Leiden G1691A and PAI-1 4G/5G mutations. J Pediatr Endocrinol Metab 2015;28:1183–6.10.1515/jpem-2015-0056Search in Google Scholar PubMed
28. Foster JR, Morrison G, Fraser DD. Diabetic ketoacidosis-associated stroke in children and youth. Stroke Res Treat 2011;2011:219706.10.4061/2011/219706Search in Google Scholar PubMed PubMed Central
29. Curtis JR, Bohn D, Daneman D. Use of hypertonic saline in the treatment of cerebral edema in diabetic ketoacidosis (DKA). Pediatr Diabetes 2001;2:191–4.10.1034/j.1399-5448.2001.20409.xSearch in Google Scholar PubMed
30. Buendgens L, Koch A, Tacke F. Prevention of stress-related ulcer bleeding at the intensive care unit: risks and benefits of stress ulcer prophylaxis. World J Crit Care Med 2016;5:57–64.10.5492/wjccm.v5.i1.57Search in Google Scholar PubMed PubMed Central
©2016 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Original Articles
- Decreased undercarboxylated osteocalcin in children with type 2 diabetes mellitus
- Evaluation of left and right ventricular functions using conventional and tissue Doppler echocardiography in children with type 1 diabetes mellitus
- Prevalence of psychosocial morbidity in children with type 1 diabetes mellitus: a survey from Northern India
- Increased GLP-1 response to oral glucose in pre-pubertal obese children
- Prevalence of idiopathic intracranial hypertension and associated factors in obese children and adolescents
- Idiopathic postprandial hyperinsulinaemic hypoglycaemia
- Feeding, eating and behavioral disturbances in Prader-Willi syndrome and non-syndromal obesity
- Interpretation of thyroid glands in a group of healthy children: real-time ultrasonography elastography study
- Ghrelin, insulin-like growth factor I and adipocytokines concentrations in born small for gestational age prepubertal children after the catch-up growth
- Zoledronate for Osteogenesis imperfecta: evaluation of safety profile in children
- Elevated serum adiponectin is related to elevated serum ferritin and interleukin-6 in β-thalassaemia major children
- GCK mutations in Chinese MODY2 patients: a family pedigree report and review of Chinese literature
- Cystinosis in Eastern Turkey
- Microarray analysis of slipped capital femoral epiphysis growth plates
- Case Reports
- Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: report of three cases from Iran
- Type 1 diabetes and GAD65 limbic encephalitis: a case report of a 10-year-old girl
- A novel splice site mutation in the GNPTAB gene in an Iranian patient with mucolipidosis II α/β
- Parent observed neuro-behavioral and pro-social improvements with oxytocin following surgical resection of craniopharyngioma
- A fatal outcome of complicated severe diabetic ketoacidosis in a 11-year-old girl
Articles in the same Issue
- Frontmatter
- Original Articles
- Decreased undercarboxylated osteocalcin in children with type 2 diabetes mellitus
- Evaluation of left and right ventricular functions using conventional and tissue Doppler echocardiography in children with type 1 diabetes mellitus
- Prevalence of psychosocial morbidity in children with type 1 diabetes mellitus: a survey from Northern India
- Increased GLP-1 response to oral glucose in pre-pubertal obese children
- Prevalence of idiopathic intracranial hypertension and associated factors in obese children and adolescents
- Idiopathic postprandial hyperinsulinaemic hypoglycaemia
- Feeding, eating and behavioral disturbances in Prader-Willi syndrome and non-syndromal obesity
- Interpretation of thyroid glands in a group of healthy children: real-time ultrasonography elastography study
- Ghrelin, insulin-like growth factor I and adipocytokines concentrations in born small for gestational age prepubertal children after the catch-up growth
- Zoledronate for Osteogenesis imperfecta: evaluation of safety profile in children
- Elevated serum adiponectin is related to elevated serum ferritin and interleukin-6 in β-thalassaemia major children
- GCK mutations in Chinese MODY2 patients: a family pedigree report and review of Chinese literature
- Cystinosis in Eastern Turkey
- Microarray analysis of slipped capital femoral epiphysis growth plates
- Case Reports
- Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: report of three cases from Iran
- Type 1 diabetes and GAD65 limbic encephalitis: a case report of a 10-year-old girl
- A novel splice site mutation in the GNPTAB gene in an Iranian patient with mucolipidosis II α/β
- Parent observed neuro-behavioral and pro-social improvements with oxytocin following surgical resection of craniopharyngioma
- A fatal outcome of complicated severe diabetic ketoacidosis in a 11-year-old girl