Interpretation of thyroid glands in a group of healthy children: real-time ultrasonography elastography study
-
Nursel Yurttutan
,
Gulay Gungor
Abstract
Background:
This study aimed to determine the strain index (SI) of normal thyroid parenchyma in a group of healthy children, using ultrasound elastography (USE).
Methods:
The participants consisted of 54 healthy children. The USE of the normal thyroid parenchyma was performed by using the Hitachi Hi VisionPreirus model ultrasonography (US) device. By following sinusoidal waves at the base of the screen, regular and slight compressions and decompressions were made by the transducer. After the regular sinusoidal waves were acquired, standard region of interest (ROI) circles were used to measure the SI values of the thyroid glands by placing one ROI on a superficial part of the normal thyroid gland parenchyma and the other on the adjacent soft tissue at the same depth (within 10-mm proximity). Three measurements were obtained for each (right and left) thyroid gland, and the mean value was used for statistics.
Results:
The mean SI value of normal thyroid glands was 0.54±0.38 for the whole group. There was no statistically significant difference between girls and boys on the basis of age, weight, height, BMI (body mass index), and thyroid SI values (p=0.15, p=0.18, p=0.12, p=0.31, and p=0.96, respectively). No correlation was found between thyroid gland SI values and each of the following variables: age (r=0.22, p=0.15), gender (r=0.007, p=0.96), and BMI (r=0.26, p=0.09).
Conclusions:
The study determined the normal elasticity values of thyroid glands in healthy children. Such information can serve as a baseline from which thyroid diseases can be examined.
Acknowledgments:
The English in this document has been checked by at least two professional editors, both native speakers of English.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Al Nofal A, Gionfriddo MR, Javed A, Haydour Q, Brito JP, et al. Accuracy of thyroid nodule sonography for the detection of thyroid cancer in children: systematic review and meta-analysis. Clin Endocrinol (Oxf) 2016;84:423–30.10.1111/cen.12786Suche in Google Scholar PubMed
2. Pearce EN, Farwell AP, Braverman LE. Thyroiditis. N Engl J Med 2003;348:2646–55.10.1056/NEJMra021194Suche in Google Scholar PubMed
3. Kim SJ, Kim EK, Park CS, Chung WY, Oh KK, et al. Ultrasound-guided fine-needle aspiration biopsy in nonpalpable thyroid nodules: is it useful in infracentimetric nodules? Yonsei Med J 2003;44:635–40.10.3349/ymj.2003.44.4.635Suche in Google Scholar PubMed
4. Bamber J, Cosgrove D, Dietrich CF, Fromageau J, Bojunga J, et al. EF SUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 1: basic principles and technology. Ultraschall Med 2013;34:169–84.10.1055/s-0033-1335205Suche in Google Scholar PubMed
5. Asteria C, Giovanardi A, Pizzocaro A, Cozzaglio L, Morabito A, et al. US-elastography in the differential diagnosis of benign and malignant thyroid nodules. Thyroid 2008;18:523–31.10.1089/thy.2007.0323Suche in Google Scholar PubMed
6. Rago T, Santini F, Scutari M, Pinchera A, Vitti P. Elastography: new developments in ultrasound for predicting malignancy in thyroid nodules. J Clin Endocrinol Metab 2007;92:2917–22.10.1210/jc.2007-0641Suche in Google Scholar PubMed
7. Kim I, Kim EK, Yoon JH, Han KH, Son EJ, et al. Diagnostic role of conventional ultrasonography and shearwave elastography in asymptomatic patients with diffuse thyroid disease: initial experience with 57 patients. Yonsei Med J 2014;55:247–53.10.3349/ymj.2014.55.1.247Suche in Google Scholar PubMed PubMed Central
8. Taş F, Bulut S, Eğilmez H, Oztoprak I, Ergür AT, et al. Normal thyroid volume by ultrasonography in healthy children. Ann Trop Paediatr 2002;22:375–9.10.1179/027249302125002047Suche in Google Scholar PubMed
9. Garra BS. Imaging and estimation of tissue elasticity by ultrasound. Ultrasound 2007;23:255–68.10.1097/ruq.0b013e31815b7ed6Suche in Google Scholar PubMed
10. Franchi-Abella S, Elie C, Correas JM. Ultrasound elastography: advantages, limitations and artefacts of the different techniques from a study on a phantom. Diagn Interv Imaging 2013;94:497–501.10.1016/j.diii.2013.01.024Suche in Google Scholar PubMed
11. Onur MR, Poyraz AK, Ucak EE, Bozgeyik Z, Özercan IH, et al. Semiquantitative strain elastography of livermasses. J Ultrasound Med 2012;31:1061–7.10.7863/jum.2012.31.7.1061Suche in Google Scholar PubMed
12. Niedziela M. Pathogenesis, diagnosis and management of thyroid nodules in children. Endocr Relat Cancer 2006;13:427–53.10.1677/erc.1.00882Suche in Google Scholar PubMed
13. Grigsby PW, Gal-or A, Michalski JM, Doherty GM. Childhood and adolescent thyroid carcinoma. Cancer 2002;95:724–9.10.1002/cncr.10725Suche in Google Scholar PubMed
14. Brown RS. Autoimmune thyroiditis in childhood. J Clin Res Pediatr Endocrinol 2013;1:45–9.10.4274/jcrpe.855Suche in Google Scholar PubMed PubMed Central
15. Hemminki K, Li X, Sundquist J, Sundquist K. The epidemiology of Graves’ disease: evidence of a genetic and an environmental contribution. J Autoimmun 2010;34:J307–13.10.1016/j.jaut.2009.11.019Suche in Google Scholar PubMed
16. Brix TH, Hegedüs L. Twin studies as a model for exploring the aetiology of autoimmune thyroid disease. Clin Endocrinol 2012;76:457–64.10.1111/j.1365-2265.2011.04318.xSuche in Google Scholar PubMed
17. Moon WJ, Baek JH, Jung SL, Kim DW, Kim EK, et al. Ultrasonography and the ultrasound-based management of thyroid nodules: consensus statement and recommendations. Korean J Radiol 2011;12:1–14.10.3348/kjr.2011.12.1.1Suche in Google Scholar PubMed PubMed Central
18. Lyshchik A, Higashi T, Asato R, Tanaka S, Ito J, et al. Thyroid gland tumor diagnosis at US elastography. Radiology 2005;237:202–11.10.1148/radiol.2363041248Suche in Google Scholar PubMed
19. Xing P, Wu L, Zhang C, Li S, Liu C, et al. Differentiation of benign from malignant thyroid lesions. Calculation of the strain index on thyroid sonoelastography. J Ultrasound Med 2011;30:663–9.10.7863/jum.2011.30.5.663Suche in Google Scholar PubMed
20. Wang HL, Zhang S, Xin XJ, Zhao LH, Li CX, et al. Application of real-time ultrasound elastography in diagnosing benign and malignant thyroid solid nodules. Cancer Biol Med 2012;9:124–7.Suche in Google Scholar
21. Ning CP, Jiang SQ, Zhang T, Sun LT, Liu YJ, et al. The value of strain index in differential diagnosis of thyroid solid nodules. Eur J Radiol 2012;81:286–91.10.1016/j.ejrad.2010.12.010Suche in Google Scholar PubMed
22. Menzilcioglu MS, Duymus M, Gungor G, Citil S, Sahin T, et al. The value of real-time ultrasound elastography in chronic autoimmune thyroiditis. Br J Radiol 2014;87:20140604.10.1259/bjr.20140604Suche in Google Scholar PubMed PubMed Central
©2016 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Original Articles
- Decreased undercarboxylated osteocalcin in children with type 2 diabetes mellitus
- Evaluation of left and right ventricular functions using conventional and tissue Doppler echocardiography in children with type 1 diabetes mellitus
- Prevalence of psychosocial morbidity in children with type 1 diabetes mellitus: a survey from Northern India
- Increased GLP-1 response to oral glucose in pre-pubertal obese children
- Prevalence of idiopathic intracranial hypertension and associated factors in obese children and adolescents
- Idiopathic postprandial hyperinsulinaemic hypoglycaemia
- Feeding, eating and behavioral disturbances in Prader-Willi syndrome and non-syndromal obesity
- Interpretation of thyroid glands in a group of healthy children: real-time ultrasonography elastography study
- Ghrelin, insulin-like growth factor I and adipocytokines concentrations in born small for gestational age prepubertal children after the catch-up growth
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- Elevated serum adiponectin is related to elevated serum ferritin and interleukin-6 in β-thalassaemia major children
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- Cystinosis in Eastern Turkey
- Microarray analysis of slipped capital femoral epiphysis growth plates
- Case Reports
- Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: report of three cases from Iran
- Type 1 diabetes and GAD65 limbic encephalitis: a case report of a 10-year-old girl
- A novel splice site mutation in the GNPTAB gene in an Iranian patient with mucolipidosis II α/β
- Parent observed neuro-behavioral and pro-social improvements with oxytocin following surgical resection of craniopharyngioma
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Artikel in diesem Heft
- Frontmatter
- Original Articles
- Decreased undercarboxylated osteocalcin in children with type 2 diabetes mellitus
- Evaluation of left and right ventricular functions using conventional and tissue Doppler echocardiography in children with type 1 diabetes mellitus
- Prevalence of psychosocial morbidity in children with type 1 diabetes mellitus: a survey from Northern India
- Increased GLP-1 response to oral glucose in pre-pubertal obese children
- Prevalence of idiopathic intracranial hypertension and associated factors in obese children and adolescents
- Idiopathic postprandial hyperinsulinaemic hypoglycaemia
- Feeding, eating and behavioral disturbances in Prader-Willi syndrome and non-syndromal obesity
- Interpretation of thyroid glands in a group of healthy children: real-time ultrasonography elastography study
- Ghrelin, insulin-like growth factor I and adipocytokines concentrations in born small for gestational age prepubertal children after the catch-up growth
- Zoledronate for Osteogenesis imperfecta: evaluation of safety profile in children
- Elevated serum adiponectin is related to elevated serum ferritin and interleukin-6 in β-thalassaemia major children
- GCK mutations in Chinese MODY2 patients: a family pedigree report and review of Chinese literature
- Cystinosis in Eastern Turkey
- Microarray analysis of slipped capital femoral epiphysis growth plates
- Case Reports
- Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy: report of three cases from Iran
- Type 1 diabetes and GAD65 limbic encephalitis: a case report of a 10-year-old girl
- A novel splice site mutation in the GNPTAB gene in an Iranian patient with mucolipidosis II α/β
- Parent observed neuro-behavioral and pro-social improvements with oxytocin following surgical resection of craniopharyngioma
- A fatal outcome of complicated severe diabetic ketoacidosis in a 11-year-old girl
