Startseite Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder
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Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder

  • Fatih Gurbuz EMAIL logo , Berrak Bilginer Gurbuz , Gonca Gul Celik , Veli Yildirim , Seyit Ahmet Ucakturk , Gulsah Seydaoglu , Eda Mengen Ucakturk ORCID logo , Ali Kemal Topaloglu und Bilgin Yuksel
Veröffentlicht/Copyright: 15. August 2015

Abstract

The purpose of this study was to determine the levels of leptin, ghrelin, and nesfatin-1 to elucidate the causes of poor appetite and growth retardation in patients receiving methylphenidate therapy for attention deficit hyperactivity disorder. The study was performed on 89 male subjects; 48 patients and 41 healthy controls, aged 7–14 years. Following treatment, patients’ leptin levels increased and ghrelin levels decreased while no significant change was found in nesfatin-1 levels. Of the 48 patients, 34 developed lack of appetite. In patients who developed lack of appetite, body weight SDS, body mass index (BMI), and BMI SDS were statistically significantly reduced; moreover, height SDS was reduced, though not to a statistically significant extent. This study attempted to elucidate the mechanisms that mediate the association between methylphenidate and appetite and growth, for which no studies have yet to be published.


Corresponding author: Fatih Gurbuz, MD, Number of ESPE Membership: 123115 Cukurova University Medical Faculty, Department of Pediatric Endocrinology, Adana 01330, Turkey, Tel: +90 322 3386060 /3252, Mobile phone: +09 505 7077366, Fax: +90 322 3387717, E-mail:

Acknowledgments

This study was supported by the Cukurova University Scientific Research Projects, TURKEY, Project No: TF2012LTP28.

Disclosure statement: The authors have nothing to disclose.

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Received: 2015-4-22
Accepted: 2015-7-20
Published Online: 2015-8-15
Published in Print: 2016-1-1

©2016 by De Gruyter

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