Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder
-
Fatih Gurbuz
, Berrak Bilginer Gurbuz
, Ali Kemal Topaloglu
Abstract
The purpose of this study was to determine the levels of leptin, ghrelin, and nesfatin-1 to elucidate the causes of poor appetite and growth retardation in patients receiving methylphenidate therapy for attention deficit hyperactivity disorder. The study was performed on 89 male subjects; 48 patients and 41 healthy controls, aged 7–14 years. Following treatment, patients’ leptin levels increased and ghrelin levels decreased while no significant change was found in nesfatin-1 levels. Of the 48 patients, 34 developed lack of appetite. In patients who developed lack of appetite, body weight SDS, body mass index (BMI), and BMI SDS were statistically significantly reduced; moreover, height SDS was reduced, though not to a statistically significant extent. This study attempted to elucidate the mechanisms that mediate the association between methylphenidate and appetite and growth, for which no studies have yet to be published.
Acknowledgments
This study was supported by the Cukurova University Scientific Research Projects, TURKEY, Project No: TF2012LTP28.
Disclosure statement: The authors have nothing to disclose.
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©2016 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- EDITORIAL
- Newborn screening of metabolic disorders
- Current and future perspective of newborn screening: an Indian scenario
- Hawkinsinuria in two unrelated Greek newborns: identification of a novel variant, biochemical findings and treatment
- Leptin and neuropeptide Y levels in newborns
- Markers of bone metabolism, serum leptin levels and bone mineral density in preterm babies
- Adipokines in umbilical cord blood from children born large for gestational age
- REVIEW
- Diabetes insipidus in children
- ORIGINAL ARTICLES
- Essential oils reduce autonomous response to pain sensation during self-monitoring of blood glucose among children with diabetes
- The prevalence of melanocortin-4 receptor gene mutations in Slovak obese children and adolescents
- Physical activity does not attenuate the relationship between daily cortisol and metabolic syndrome in obese youth
- Evaluation of the tshr gene reveals polymorphisms associated with typical symptoms in primary congenital hypothyroidism
- The effect of tamoxifen on pubertal bone development in adolescents with pubertal gynecomastia
- Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder
- CASE REPORTS
- An unusual case of hereditary nephrogenic diabetes insipidus (HNDI) affecting mother and daughter
- Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome and celiac disease in a 13-year-old girl: further evidence for autoimmunity?
- Prepubertal gynecomastia and chronic lavender exposure: report of three cases
- An adolescent girl referred with Cushing syndrome – does she or does she not have the syndrome?
Artikel in diesem Heft
- Frontmatter
- EDITORIAL
- Newborn screening of metabolic disorders
- Current and future perspective of newborn screening: an Indian scenario
- Hawkinsinuria in two unrelated Greek newborns: identification of a novel variant, biochemical findings and treatment
- Leptin and neuropeptide Y levels in newborns
- Markers of bone metabolism, serum leptin levels and bone mineral density in preterm babies
- Adipokines in umbilical cord blood from children born large for gestational age
- REVIEW
- Diabetes insipidus in children
- ORIGINAL ARTICLES
- Essential oils reduce autonomous response to pain sensation during self-monitoring of blood glucose among children with diabetes
- The prevalence of melanocortin-4 receptor gene mutations in Slovak obese children and adolescents
- Physical activity does not attenuate the relationship between daily cortisol and metabolic syndrome in obese youth
- Evaluation of the tshr gene reveals polymorphisms associated with typical symptoms in primary congenital hypothyroidism
- The effect of tamoxifen on pubertal bone development in adolescents with pubertal gynecomastia
- Effects of methylphenidate on appetite and growth in children diagnosed with attention deficit and hyperactivity disorder
- CASE REPORTS
- An unusual case of hereditary nephrogenic diabetes insipidus (HNDI) affecting mother and daughter
- Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome and celiac disease in a 13-year-old girl: further evidence for autoimmunity?
- Prepubertal gynecomastia and chronic lavender exposure: report of three cases
- An adolescent girl referred with Cushing syndrome – does she or does she not have the syndrome?