Rare and curable renin-mediated hypertension: a series of six cases and a literature review
-
Wei-Jun Gu
,
Jun Dong
Abstract
Background: Reninoma is an extremely rare renal tumor characterized by excessive renin secretion causing secondary hypertension and hypokalemia. Reninoma is a benign and highly manageable lesion if it is discovered early and removed surgically.
Methods: We report six cases of reninoma and provide a literature review on this rare disease, highlighting the diagnostic evaluation and follow-up of each patient.
Results and conclusions: Reninoma should be considered in young adults with elevated renin activity and refractory hypertension. Imaging studies and selective venous catheterization are often helpful in identifying the lesion. In most cases of reninoma presenting with renin-mediated hypertension, conservative surgical treatment should be considered to remove the small, superficial lesion.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Saito T, Fukamizu A, Okada K, Ishikawa S, Iwamoto Y, et al. Ectopic production of renin by ileal carcinoma. Endocrinol Jpn 1989;36:117–24.10.1507/endocrj1954.36.117Search in Google Scholar
2. Pursell RN, Quinlan PM. Secondary hypertension due to a renin-producing teratoma. Am J Hypertens 2003;16:592–5.10.1016/S0895-7061(03)00865-3Search in Google Scholar
3. Wong L, Hsu TH, Perlroth MG, Hofmann LV, Haynes CM, et al. Reninoma: case report and literature review. J Hypertens 2008;26:368–73.10.1097/HJH.0b013e3282f283f3Search in Google Scholar
4. Corvol P, Ménard J. Renin inhibition: immunological procedures and renin inhibitor peptides. Kidney Int 1988;26(Supp l):S73–9.Search in Google Scholar
5. Lin SY, Liu WY, Chen WC, Chen RH. Secondary hypertension due to a renin-secreting juxtaglomerular cell tumor. J Formos Med Assoc 2010;109:237–40.10.1016/S0929-6646(10)60047-2Search in Google Scholar
6. Gottardo F, Cesari M, Morra A, Gardiman M, Fassina A, et al. A kidney tumor in an adolescent with severe hypertension and hypokalemia: an uncommon case – case report and review of the literature on reninoma. Urol Int 2010;85:121–4.10.1159/000314339Search in Google Scholar
7. Mete UK, Niranjan J, Kusum J, Rajesh LS, Goswami AK, et al. Reninoma treated with nephron-sparing surgery. Urology 2003;61:1259iii-v.10.1016/S0090-4295(03)00104-3Search in Google Scholar
8. Sakata R, Shimoyamada H, Yanagisawa M, Murakami T, Makiyama K, et al. Nonfunctioning juxtaglomerular cell tumor. Case Rep Pathol 2013;2013:973865.10.1155/2013/973865Search in Google Scholar PubMed PubMed Central
9. Endoh Y, Motoyama T, Hayami S, Kihara I. Juxtaglomerular cell tumor of the kidney: report of a nonfunctioning variant. Pathol Int 1997;47:393–6.10.1111/j.1440-1827.1997.tb04513.xSearch in Google Scholar PubMed
10. Henderson NL, Mason RC. Juxtaglomerular cell tumor in pregnancy. Obstet Gynecol 2001;98:943–5.Search in Google Scholar
11. Liborio AB, Marques Fde O, Testagrossa L, Leite CA, Leitao AA, et al. Malignant hypertension with intestinal ischemia secondary to juxtaglomerular cell tumor. Am J Kidney Dis 2005;46:957–61.10.1053/j.ajkd.2005.07.032Search in Google Scholar PubMed
12. Kim HJ, Kim CH, Choi YJ, Ayala AG, Amirikachi M, et al. Juxtaglomerular cell tumor of kidney with CD34 and CD117 immunoreactivity: report of 5 cases. Arch Pathol Lab Med 2006;130:707–11.10.5858/2006-130-707-JCTOKWSearch in Google Scholar PubMed
13. Brand G, Vandongen R, Beilin LJ, Matz L. Juxtaglomerular tumour: diagnostic renal vein renin measurements obscured by chronic captopril therapy. Aust NZ J Med 1985;15:755–7.Search in Google Scholar
14. Corvol P, Pinet F, Plouin PF, Bruneval P, Menard J. Renin-secreting tumors. Endocrinol Metab Clin North Am 1994;23:255–70.10.1016/S0889-8529(18)30096-3Search in Google Scholar
15. Hanna W, Tepperman B, Logan AG, Robinette MA, Colapinto R, et al. Juxtaglomerular cell tumour (reninoma) with paroxysmal hypertension. Can Med Assoc J 1979;120:957–9.Search in Google Scholar
16. Duan X, Bruneval P, Hammadeh R, Fresco R, Eble JN, et al. Meastatic juxtaglomerular cell tumor in a 52-year-old man. Am J Surg Pathol 2004;28:1098–102.10.1097/01.pas.0000126722.29212.a7Search in Google Scholar PubMed
17. Beaudoin J, Périgny M, Têtu B, Lebel M. A patient with a juxtaglomerular cell tumor with histological vascular invasion. Nat Clin Pract Nephrol 2008;4:458–62.10.1038/ncpneph0890Search in Google Scholar PubMed
©2016 by De Gruyter
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Articles in the same Issue
- Frontmatter
- REVIEW
- Obesity-associated sympathetic overactivity in children and adolescents: the role of catecholamine resistance in lipid metabolism
- MINI REVIEW
- Idiopathic infantile hypercalcemia: case report and review of the literature
- ORIGINAL ARTICLES
- Levothyroxine replacement in primary congenital hypothyroidism: the higher the initial dose the higher the rate of overtreatment
- Effect of auditory guided imagery on glucose levels and on glycemic control in children with type 1 diabetes mellitus
- Kidney injury molecule-1 and neutrophil gelatinase associated lipocalin in normoalbuminuric diabetic children
- Use of the triglyceride to HDL cholesterol ratio for assessing insulin sensitivity in overweight and obese children in rural Appalachia
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- Barriers in communication and available resources to facilitate conversation about infertility with girls diagnosed with Turner syndrome
- Analysis of the PAX8 gene in 32 children with thyroid dysgenesis and functional characterization of a promoter variant
- Decrease of small dense LDL and lipoprotein-associated phospholipase A2 due to human growth hormone treatment in short children with growth hormone deficiency and small for gestational age status
- Rare and curable renin-mediated hypertension: a series of six cases and a literature review
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- Vulvar fetal rhabdomyoma mimicking 46XX sex differentiation disorder
- Simultaneous occurrence of diabetic ketoacidosis, thyroid storm, and multiple cerebral infarctions due to Moyamoya disease
- Brown-Vialetto-Van Laere syndrome: two siblings with a new mutation and dramatic therapeutic effect of high-dose riboflavin
- Lipomatous nevus and urethral caruncle mistaken for ambiguous genitalia in a female infant
- Thyrotropin-secreting pituitary adenoma in an 11-year-old boy with type 1 autoimmune polyglandular syndrome
- Changes in facial appearance from neonate to adult in 3-M syndrome patient with novel CUL7 gene mutations
