Carotid intima media thickness in obese children: is there an association with hyperlipidemia?
-
Zehra Esra Önal
,
Levent Soydan
Abstract
Background: We aimed to evaluate the association between hyperlipidemia and carotid intima media thickness in obese children, compared to non-obese ones.
Methods: Two hundred (110 girls, 90 boys) children aged between 6 and 15 years participated in this study. The obese group included 53 girls, 47 boys whose body mass indices (BMI) above 95th percentile, the control group included 57 girls, 43 boys who had normal weight. Fasting total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) levels were measured. Carotid intima media thickness (cIMT) was performed with neck ultrasound.
Results: The median thickness of right, left and mean carotis intima media were statistically higher in the study group, compared to the control group. The mean cholesterol, triglyceride, HDL-C, LDL-C levels of the study group were statistically higher, compared to the control group. There was no relationship between BMI and left carotis intima media thickness, but there was statistically significant relationship between BMI and right, mean cIMTs in the study group. There was no correlation between serum lipid levels and cIMTs in the study group. The mean atherogenic index of the study group was statistically higher, compared to the control group. There was no statistical correlation between atherogenic index and cIMTs in both of the groups.
Conclusions: We observed that obese children had higher carotis intima media thicknesses. Carotis intima media thickness related to obesity can play an important role in future pre-atherosclerotic changes. Large population based studies are required to confirm this associaton.
References
1. Ferroni P, Basili S, Fako A, Davi G. Inflammation, insulin resistance and obesity. Curr Atheroscler rep 2004;6:424–31.10.1007/s11883-004-0082-xSearch in Google Scholar
2. Lakka TA, Lakka HM, Salonen R, Kaplan GA, Salonen JT. Abdominal obesity is associated with accelerated progression of carotid atherosclerosis in men. Atherosclerosis 2001;154:497–504.10.1016/S0021-9150(00)00514-1Search in Google Scholar
3. De Michele M, Panico S, Iannuzzi A, Celentana E, Ciardullo AV, et al. Association of obesity and central fat distribution with carotid artery wall thickening in middle-aged women. Stroke 2002;33:2923–8.10.1161/01.STR.0000038989.90931.BESearch in Google Scholar
4. Chambless LE, Heiss G, Falsom AR, Rosamond W, Szklo M, et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors:the atherosclerosis risk in communities (ARIC) study 1987–1999. Am J Epidemiol 1997;146:483–94.10.1093/oxfordjournals.aje.a009302Search in Google Scholar
5. O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, et al. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular health study collaborative research group. N Engl J Med 1999;340:14–22.10.1056/NEJM199901073400103Search in Google Scholar
6. Litwin N, Niemirska A. Intima-media thickness measurements in children with cardiovascular risk factors. Pediatr Nephrol 2009;24:707–19.10.1007/s00467-008-0962-3Search in Google Scholar
7. Kawamato R, Ohtsuka N, Ninomiya D, Nakamura S. Association of obesity and visceral fat distribution with intima-media thickness of carotid arteries in middle-aged and older persons. Intern Med 2008;47:143–7.10.2169/internalmedicine.47.0478Search in Google Scholar
8. Kim SK, Park SW, Kim SH, Cha BS, Lee HC, et al. Visceral fat amount is associated with carotid atherosclerosis even in type 2 diabetic men with a normal waist circumference. Int J Obes (Lond) 2009;33:131–5.10.1038/ijo.2008.222Search in Google Scholar
9. Gnasso A, Irace C, Mattioli PL, Pujia A. Carotid intima-media thickness and coronary heart disease risk factors. Atherosclerosis 1996;119:7–15.10.1016/0021-9150(95)05625-4Search in Google Scholar
10. Raitakari OT, Jounala M, Köhönen M, Taittonen L, Laitinen T, et al. Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the cardiovascular risk in young finns study. J Am Med Assoc 2003;290:2273–83.10.1001/jama.290.17.2277Search in Google Scholar PubMed
11. Caserta CA, Pendino GM, Amante A, Vacalebre C, Fiorillo MT, et al. Cardiovascular risk factors, nonalcoholic fatty liver disease and carotid artery intima-media thickness in an adolescent population in southern Italy. Am J Epidemiol 2010;171:1195–202.10.1093/aje/kwq073Search in Google Scholar PubMed
12. Lee YJ, Nam JM, Kim HC, Hur NW, Suh I. The association between obesity indices in adolescence and carotid intima-media thickness in young adults. J Prev Med Public Health 2008;41:107–14.10.3961/jpmph.2008.41.2.107Search in Google Scholar PubMed
13. Leite A, Santos A, Monteiro M, Gomes L, Veloso M, et al. Impact of overweight and obesity in carotid intima-media thickness of Portugese adolescents. Acta Paediatr 2012;101:e115–21.10.1111/j.1651-2227.2011.02503.xSearch in Google Scholar PubMed
14. Stabouli S, Kotsis V, Karagianni C, Zokopoulas N, Konstantopoulas A. Blood pressure and carotid artery intima-media thickness in children and adolescents; the role of obesity. Hellenic J Cardiol 2012;53:41–7.Search in Google Scholar
15. Kusters DM, Wiegman A, Kostelein JJ, Hutten BA. Carotid intima-media thickness in children with familial hypercholesterolemia. Circle Res 2014;114:307–10.10.1161/CIRCRESAHA.114.301430Search in Google Scholar PubMed
16. Reinehr T, Wunsch R, Putter C, Scherog A. Relationship between carotid intima-media thickness and metabolic syndrome in adolescents. J Pediatr 2013;163:327–32.10.1016/j.jpeds.2013.01.032Search in Google Scholar PubMed
17. Beauloye V, Zech F, Tran HT, Clapyt P, Maes M, et al. Determinants of early atherosclerosis in obese children and adolescents. J Clin Endocrinol Metab 2007;92:3025–32.10.1210/jc.2007-0619Search in Google Scholar PubMed
18. Chaubey S, Nitsch D, Altmann D, Ebrahim S. Differing effect of modifiable cardiovascular risk factors on intima-media thickening and plaque formation at different sites of the arterial vasculature. Heart 2010;96:1579–85.10.1136/hrt.2009.188219Search in Google Scholar PubMed
19. Rodrigues Hernandez SA, Kroon AA, van Boxtel MP, Mess WH, Lodder J, et al. Is there a side predilection for cerebrovascular disease? Hypertension 2003;42:56–60.10.1161/01.HYP.0000077983.66161.6FSearch in Google Scholar PubMed
20. Pahkala K, Laitinen TT, Heinonen OJ, Viikari JS, Ronnemaa T, et al. Association of fitness with Vascular Intıma-media thickness and elasticity in adolescence. Pediatrics 2013;132:e77–84.10.1542/peds.2013-0041Search in Google Scholar PubMed
21. Meyer AA, Kundt G, Lenschaw U, Schuff-Werner P, Kienast W. Improvement of early vascular changes and cardiovascular risk factors in obese children after a six-month exercise programm. J Am Coll Cardiol 2006;48:1865–70.10.1016/j.jacc.2006.07.035Search in Google Scholar PubMed
22. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents, national heart, lung and blood ınstitute. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics 2011;128: S 213–56.10.1542/peds.2009-2107CSearch in Google Scholar PubMed PubMed Central
23. Pacifico L, Bonci E, Andreoli G, Romaggioli S, Di Miscio R, et al. Association of serum triglyceride to HDL cholesterol ratio with carotid artery intima-media thickness, insulin resistance and nonalcoholic fatty liver disease in children and adolescents. Nutr Metab Cardiovasc Dis 2014;24:737–43.10.1016/j.numecd.2014.01.010Search in Google Scholar PubMed
24. Gazolla FM, Neves Bordallo MA, Madura IR, de Miranda Carvalho CN, Vieira Monteiro AM, et al. Association between cardiovascular risk factors and carotid intima-media thickness in prepubertal Brazilion children. J Pediatr Endocrinol Metab 2015;28:579–87.10.1515/jpem-2014-0116Search in Google Scholar PubMed
25. Okur I, Tumer L, Ezgu FS, Yeşilkaya E, Aral A, et al. Oxidized low density lipoprotein levels and carotid intima-media thickness as markers of early atherosclerosis in prepubertal obese children. J Pediatr Endocrinal Metab 2013;26:657–62.10.1515/jpem-2012-0374Search in Google Scholar PubMed
©2016 by De Gruyter
Articles in the same Issue
- Frontmatter
- REVIEW
- Obesity-associated sympathetic overactivity in children and adolescents: the role of catecholamine resistance in lipid metabolism
- MINI REVIEW
- Idiopathic infantile hypercalcemia: case report and review of the literature
- ORIGINAL ARTICLES
- Levothyroxine replacement in primary congenital hypothyroidism: the higher the initial dose the higher the rate of overtreatment
- Effect of auditory guided imagery on glucose levels and on glycemic control in children with type 1 diabetes mellitus
- Kidney injury molecule-1 and neutrophil gelatinase associated lipocalin in normoalbuminuric diabetic children
- Use of the triglyceride to HDL cholesterol ratio for assessing insulin sensitivity in overweight and obese children in rural Appalachia
- Carotid intima media thickness in obese children: is there an association with hyperlipidemia?
- Schoolchildren born VLBW or VLGA show height-related changes in body composition and muscle function but no evidence of metabolic syndrome risk factors. Results from the NEOLONG study
- Topical dihydrotestosterone to treat micropenis secondary to partial androgen insensitivity syndrome (PAIS) before, during, and after puberty – a case series
- Urinary myo-inositol levels in Japanese schoolchildren with normal glucose tolerance
- Barriers in communication and available resources to facilitate conversation about infertility with girls diagnosed with Turner syndrome
- Analysis of the PAX8 gene in 32 children with thyroid dysgenesis and functional characterization of a promoter variant
- Decrease of small dense LDL and lipoprotein-associated phospholipase A2 due to human growth hormone treatment in short children with growth hormone deficiency and small for gestational age status
- Rare and curable renin-mediated hypertension: a series of six cases and a literature review
- CASE REPORTS
- Vulvar fetal rhabdomyoma mimicking 46XX sex differentiation disorder
- Simultaneous occurrence of diabetic ketoacidosis, thyroid storm, and multiple cerebral infarctions due to Moyamoya disease
- Brown-Vialetto-Van Laere syndrome: two siblings with a new mutation and dramatic therapeutic effect of high-dose riboflavin
- Lipomatous nevus and urethral caruncle mistaken for ambiguous genitalia in a female infant
- Thyrotropin-secreting pituitary adenoma in an 11-year-old boy with type 1 autoimmune polyglandular syndrome
- Changes in facial appearance from neonate to adult in 3-M syndrome patient with novel CUL7 gene mutations
Articles in the same Issue
- Frontmatter
- REVIEW
- Obesity-associated sympathetic overactivity in children and adolescents: the role of catecholamine resistance in lipid metabolism
- MINI REVIEW
- Idiopathic infantile hypercalcemia: case report and review of the literature
- ORIGINAL ARTICLES
- Levothyroxine replacement in primary congenital hypothyroidism: the higher the initial dose the higher the rate of overtreatment
- Effect of auditory guided imagery on glucose levels and on glycemic control in children with type 1 diabetes mellitus
- Kidney injury molecule-1 and neutrophil gelatinase associated lipocalin in normoalbuminuric diabetic children
- Use of the triglyceride to HDL cholesterol ratio for assessing insulin sensitivity in overweight and obese children in rural Appalachia
- Carotid intima media thickness in obese children: is there an association with hyperlipidemia?
- Schoolchildren born VLBW or VLGA show height-related changes in body composition and muscle function but no evidence of metabolic syndrome risk factors. Results from the NEOLONG study
- Topical dihydrotestosterone to treat micropenis secondary to partial androgen insensitivity syndrome (PAIS) before, during, and after puberty – a case series
- Urinary myo-inositol levels in Japanese schoolchildren with normal glucose tolerance
- Barriers in communication and available resources to facilitate conversation about infertility with girls diagnosed with Turner syndrome
- Analysis of the PAX8 gene in 32 children with thyroid dysgenesis and functional characterization of a promoter variant
- Decrease of small dense LDL and lipoprotein-associated phospholipase A2 due to human growth hormone treatment in short children with growth hormone deficiency and small for gestational age status
- Rare and curable renin-mediated hypertension: a series of six cases and a literature review
- CASE REPORTS
- Vulvar fetal rhabdomyoma mimicking 46XX sex differentiation disorder
- Simultaneous occurrence of diabetic ketoacidosis, thyroid storm, and multiple cerebral infarctions due to Moyamoya disease
- Brown-Vialetto-Van Laere syndrome: two siblings with a new mutation and dramatic therapeutic effect of high-dose riboflavin
- Lipomatous nevus and urethral caruncle mistaken for ambiguous genitalia in a female infant
- Thyrotropin-secreting pituitary adenoma in an 11-year-old boy with type 1 autoimmune polyglandular syndrome
- Changes in facial appearance from neonate to adult in 3-M syndrome patient with novel CUL7 gene mutations
