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Waist-to-height ratio as a marker of low-grade inflammation in obese children and adolescents

  • Carolina Caminiti EMAIL logo , Marisa Armeno und Carmen S. Mazza
Veröffentlicht/Copyright: 17. Februar 2016
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 29 Heft 5

Abstract

Background: The epidemic of childhood obesity is associated with early atherosclerosis. Several reports have related this event to low-grade inflammation described in obesity. CRP and IL6 are markers that correlate with adiposity. The waist-to-height ratio (WtHR) is an anthropometric marker associated with insulin resistance and inflammation. The objective of this study was to assess the correlation between WtHR, metabolic complications and pro-inflammatory factors in obese children and adolescents.

Methods: Weight, height, waist circumference, glycemia, insulin, CRP, TNF-α and IL-6 were measured in the baseline sample in 280 patients 6–19 years of age with overweight or obesity (OW/OB) and 112 normal-weight controls. Logistic regression was performed using WtHR as an independent variable. p>0.05 STATA11.

Results: Mean WtHR was 0.6±0.06 in OW/OB and 0.43±0.02 in controls (p<0.01). WtHR was increased in 93% of the OW/OB vs. 2% of the controls. In the OW/OB inflammatory markers were significantly increased (p<0.01) compared to the controls (CRP 2.2 vs. 0.8; Il-6 2.9 vs. 2.1; and TNF-α 6.2 vs. 5.5). In the WtHR>0.5, insulin resistence and inflammatory markers were significantly increased (p<0.01) compared to the WtHR<0.5 (HOMA 3.4 vs. 1.4; CRP 2.3 vs. 0.6; Il-6 2.9 vs. 2.1; and TNF-α 6.4 vs. 5.55). In logistic regression, a significant independent association was found between WtHR with CRP (OR1.47), IL6 (OR1.60) and TNF-α (OR1.79).

Conclusions: Obese children and adolescents have high inflammatory markers that may increase cardiovascular risk. WtHR is associated with low-grade inflammation and may be considered a relevant anthropometric marker in the clinical practice.

Keywords: inflammation; pediatric obesity; waist-to-height ratio
Corresponding author: Carolina Caminiti, Hospital J. P. Garrahan, Nutrition Department, Combate de los Pozos 1881, CP1245 CABA, Buenos Aires, Argentina, E-mail:

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Received: 2015-10-26
Accepted: 2015-12-7
Published Online: 2016-2-17
Published in Print: 2016-5-1

©2016 by De Gruyter

Artikel in diesem Heft

  1. Frontmatter
  2. Review
  3. Resistance to thyroid hormone α, revelation of basic study to clinical consequences
  4. Original Articles
  5. Improved molecular diagnosis of patients with neonatal diabetes using a combined next-generation sequencing and MS-MLPA approach
  6. Safety and metabolic impact of Ramadan fasting in children and adolescents with type 1 diabetes
  7. Waist-to-height ratio as a marker of low-grade inflammation in obese children and adolescents
  8. Classification and clinical characterization of metabolically “healthy” obese children and adolescents
  9. Long-term BH4 (sapropterin) treatment of children with hyperphenylalaninemia – effect on median Phe/Tyr ratios
  10. Compound heterozygous mutations (p.T561M and c.2422delT) in the TPO gene associated with congenital hypothyroidism
  11. Prevalence and clinical features of polycystic ovarian syndrome in adolescents with previous childhood growth hormone deficiency
  12. Urate crystals deposition in the feet of overweight juveniles and those with symptomatic hyperuricemia: a dual-energy CT study
  13. A novel ALMS1 homozygous mutation in two Turkish brothers with Alström syndrome
  14. Novel AVPR2 mutation causing partial nephrogenic diabetes insipidus in a Japanese family
  15. Pituitary gigantism: a retrospective case series
  16. Case Reports
  17. A novel OTX2 gene frameshift mutation in a child with microphthalmia, ectopic pituitary and growth hormone deficiency
  18. A novel nonsense mutation in the WFS1 gene causes the Wolfram syndrome
  19. A 33-year-old male patient with paternal derived duplication of 14q11.2–14q22.1~22.3: clinical course, phenotypic and genotypic findings
  20. Familial Turner syndrome: the importance of information
  21. De novo mutation of PHEX in a type 1 diabetes patient
  22. Congenital hypothyroidism and thyroid dyshormonogenesis: a case report of siblings with a newly identified mutation in thyroperoxidase
https://doi.org/10.1515/jpem-2014-0526
Schlagwörter für diesen Artikel
inflammation; pediatric obesity; waist-to-height ratio

Artikel in diesem Heft

  1. Frontmatter
  2. Review
  3. Resistance to thyroid hormone α, revelation of basic study to clinical consequences
  4. Original Articles
  5. Improved molecular diagnosis of patients with neonatal diabetes using a combined next-generation sequencing and MS-MLPA approach
  6. Safety and metabolic impact of Ramadan fasting in children and adolescents with type 1 diabetes
  7. Waist-to-height ratio as a marker of low-grade inflammation in obese children and adolescents
  8. Classification and clinical characterization of metabolically “healthy” obese children and adolescents
  9. Long-term BH4 (sapropterin) treatment of children with hyperphenylalaninemia – effect on median Phe/Tyr ratios
  10. Compound heterozygous mutations (p.T561M and c.2422delT) in the TPO gene associated with congenital hypothyroidism
  11. Prevalence and clinical features of polycystic ovarian syndrome in adolescents with previous childhood growth hormone deficiency
  12. Urate crystals deposition in the feet of overweight juveniles and those with symptomatic hyperuricemia: a dual-energy CT study
  13. A novel ALMS1 homozygous mutation in two Turkish brothers with Alström syndrome
  14. Novel AVPR2 mutation causing partial nephrogenic diabetes insipidus in a Japanese family
  15. Pituitary gigantism: a retrospective case series
  16. Case Reports
  17. A novel OTX2 gene frameshift mutation in a child with microphthalmia, ectopic pituitary and growth hormone deficiency
  18. A novel nonsense mutation in the WFS1 gene causes the Wolfram syndrome
  19. A 33-year-old male patient with paternal derived duplication of 14q11.2–14q22.1~22.3: clinical course, phenotypic and genotypic findings
  20. Familial Turner syndrome: the importance of information
  21. De novo mutation of PHEX in a type 1 diabetes patient
  22. Congenital hypothyroidism and thyroid dyshormonogenesis: a case report of siblings with a newly identified mutation in thyroperoxidase
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