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Subclinical hypothyroidism in childhood and adolescense

  • Gonul Catli , Ayhan Abaci EMAIL logo , Atilla Büyükgebiz und Ece Bober
Veröffentlicht/Copyright: 25. August 2014
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 27 Heft 11-12

Abstract

Subclinical hypothyroidism (SH) is defined as a serum thyroid-stimulating hormone (TSH) level above the reference range with normal serum free thyroxin (sT4) and free triiodothyronine (sT3) levels. The prevalence of SH in children and adolescents is reported between 1.7% and 9.5%. Hashimoto’s thyroiditis is the most prevalent cause of SH in children. Although it has been suggested that SH is entirely an asymptomatic laboratory diagnosis, typical hypothyroid symptoms as well have been reported in some patients. Results of the adult studies on SH revealed that SH had unfavorable effects on cardiovascular system (atherosclerosis); metabolic parameters (dyslipidemia, insulin resistance, etc.); neuromuscular system; and cognitive functions in the long term. The number of studies investigating the effect of childhood SH on growth, bone maturation, lipid parameters, carbohydrate metabolism, neuromuscular system, and cognitive and cardiac function is limited. Knowledge about the natural history of SH is unclear even though there are numerous studies upon this subject. In children and adults, treatment of SH with L-T4 is still a matter of debate, and there is no consensus on this issue yet.

Keywords: childhood; subclinical hypothyroidism; treatment
Corresponding author: Dr. Ayhan Abaci, Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, İzmir, Turkey, Phone: +90-232-412-6076, Fax: +90-232-412-6076, E-mail:

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Received: 2014-2-20
Accepted: 2014-7-22
Published Online: 2014-8-25
Published in Print: 2014-11-1

©2014 by De Gruyter

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https://doi.org/10.1515/jpem-2014-0089
Schlagwörter für diesen Artikel
childhood; subclinical hypothyroidism; treatment

Artikel in diesem Heft

  1. Frontmatter
  2. Highlight: Cushing syndrome
  3. Fundamental principles of clinical and biochemical evaluation underlie the diagnosis and therapy of Cushing’s syndrome
  4. Cushing syndrome secondary to CRH-producing Wilms tumor in a 6 year old
  5. Cushing’s disease presenting as cholestatic hepatitis
  6. How early can one diagnose Cushing’s disease? An early diagnosis in a case of prepubertal Cushing’s disease
  7. Review article
  8. Subclinical hypothyroidism in childhood and adolescense
  9. Original articles
  10. Energy substrate metabolism in pyruvate dehydrogenase complex deficiency
  11. Chromosome 6q24 transient neonatal diabetes mellitus and protein sensitive hyperinsulinaemic hypoglycaemia
  12. Measures of pituitary gland and stalk: from neonate to adolescence
  13. Are preterm newborns who have relative hyperthyrotropinemia at increased risk of brain damage?
  14. Pseudohypoparathyroidism vs. tricho-rhino-phalangeal syndrome: patient reclassification
  15. Association of serum 25-hydroxyvitamin D with race/ethnicity and constitutive skin color in urban schoolchildren
  16. A nonsense thyrotropin receptor gene mutation (R609X) is associated with congenital hypothyroidism and heart defects
  17. Acanthosis nigricans, vitamin D, and insulin resistance in obese children and adolescents
  18. Clinical characteristics and chromosome 11p15 imprinting analysis of Silver-Russell syndrome – a Chinese experience
  19. Change in reference body mass index percentiles and deviation in overweight and obesity over 3 years in Turkish children and adolescents
  20. Long-term outcomes of pediatric Graves’ disease
  21. Accessibility of the reference center as a protective factor against ketoacidosis at the onset of diabetes in children
  22. Vitamin D, parathormone, and insulin resistance in children born large for gestational age
  23. Prevalence of vitamin D deficiency in apparently healthy children in north India
  24. Prevalence of autoantibodies in type 1 diabetes patients and its association with the clinical presentation – UAE Eastern Region experience
  25. Clinical and molecular studies related to bone metabolism in patients with congenital adrenal hyperplasia
  26. Islet neogenesis-associated protein-related pentadecapeptide improves the function of allograft after islets transplantation
  27. Anti-Mullerian hormone may be a useful adjunct in the diagnosis of polycystic ovary syndrome in nonobese adolescents
  28. Early infant feeding practice and childhood obesity: the relation of breast-feeding and timing of solid food introduction with childhood obesity
  29. Late onset X-linked adrenal hypoplasia congenita with hypogonadotropic hypgonadism due to a novel 4-bp deletion in exon 2 of NR0B1
  30. The correlation between GnRH stimulation testing and obstetric ultrasonographic parameters in precocious puberty
  31. The DATAC study: a new growth database. Description of the epidemiology, diagnosis and therapeutic attitude in a group of Spanish children with short stature
  32. Concentrations of tumour necrosis factor-α and its soluble receptors in the serum of teenagers with atherosclerosis risk factors: obesity or obesity combined with hypertension
  33. Are HDL levels lower in children with type 1 diabetes and concurrent celiac disease compared with children with type 1 diabetes only?
  34. Patient reports
  35. Hereditary vitamin D rickets: a case series in a family
  36. Two heterozygous mutations of the AMH gene in a Japanese patient with persistent Müllerian duct syndrome
  37. Two case reports of severe pediatric hyperosmolar hyperglycemia and diabetic ketoacidosis accompanied with rhabdomyolysis and acute renal failure
  38. Acquired hypothyroidism due to iodine deficiency in an American child
  39. Continuous subcutaneous IGF-1 therapy via insulin pump in a patient with Donohue syndrome
  40. Amylase/creatinine clearance ratio in diabetic ketoacidosis: a case report
  41. Worsening hypertriglyceridemia with oral contraceptive pills in an adolescent with HIV-associated lipodystrophy: a case report and review of the literature
  42. Congenital hyperinsulinism in a newborn with a novel homozygous mutation (p.Q392H) in the ABCC8 gene
  43. Short communications
  44. Polyglandular autoimmune syndrome type I – a novel AIRE mutation in a North American patient
  45. Post-hemorrhagic hydrocephalus and diabetes insipidus in preterm infants
  46. Two novel mutations in acid α-glucosidase gene in two patients with Pompe disease
  47. Letter to the Editor
  48. And what about septin 9 (SEPT9) as a binding partner of survivin in heart regeneration?
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Heruntergeladen am 3.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/jpem-2014-0089/html?lang=de
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