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Concentrations of tumour necrosis factor-α and its soluble receptors in the serum of teenagers with atherosclerosis risk factors: obesity or obesity combined with hypertension

  • Anna Obuchowicz EMAIL logo , Maria Kniażewska , Joanna Żmudzińska-Kitczak , Katarzyna Urban and Anna Gonciarz-Majda
Published/Copyright: August 15, 2014

Abstract

Introduction: Obesity and hypertension are recognised risk factors for the development of atherosclerosis. It has not been proven whether their co-existence increases the synthesis of pro-inflammatory TNF-α and what the levels of soluble receptors of this cytokine (sTNF-R) are. This study is aimed to investigate whether there exists a relationship between TNF-α and sTNF-R concentrations in blood serum with the occurrence of obesity or obesity combined with primary hypertension in teenagers.

Material and method: 68 persons, aged 9–17, including 32 persons with primary obesity (Group I) and 36 with primary obesity combined with primary hypertension (Group II). TNF-α (pg/mL) and sTNF-R (ng/mL) concentrations were determined in serum samples using the ELISA method with sets of reagents manufactured by Bender Med Systems GmbH.

Results: No significant differences in TNF-α, sTNF-R, glucose or insulin concentrations were found between Group I and Group II. These concentrations were not correlated with the age and the nutritional status of the patients or with each other in either of the groups.

Conclusion: Both obese teenagers and teenagers exhibiting obesity combined with hypertension (as two atherosclerosis risk factors) are characterised by comparable concentrations of TNF-α and its soluble receptors.


Corresponding author: Anna Obuchowicz, Chair, Department of Pediatrics in Bytom, Medical University of Silesia, Katowice, Poland, E-mail:

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Received: 2013-12-16
Accepted: 2014-7-3
Published Online: 2014-8-15
Published in Print: 2014-11-1

©2014 by De Gruyter

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