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Plasma leptin and adiponectin concentrations correlate with cardiometabolic risk and systemic inflammation in healthy, non-obese children

  • Dimitrios A. Stakos EMAIL logo , Helena I. Papaioannou , Iliana Angelidou , Elpis Mantadakis , Emmanuel Paraskakis , Christina Tsigalou and Athanasios Chatzimichael
Published/Copyright: October 23, 2013

Abstract

Background: Plasma adipocytokines are associated with metabolic profile and cardiovascular risk in obese children.

Objective: To investigate the association of plasma leptin and adiponectin concentrations with cardiometabolic risk profile and systemic inflammation in non-obese children.

Subjects: We studied 170 healthy, non-obese children (86 males, mean age 10±2 years).

Methods: Children’s current body mass index (BMI), plasma leptin and adiponectin concentrations, lipid profile, fasting plasma glucose and high sensitivity C reactive protein (hsCRP) were measured.

Results: After adjustment for age, gender and BMI, plasma leptin concentrations were positively associated with hsCRP (t=2.72, p=0.009) and fasting plasma glucose (t=4.27, p<0.0001); plasma adiponectin concentrations were negatively associated with hsCRP (t=–3.31, p=0.0016); and positively with high density lipoprotein cholesterol (t=2.32, p=0.02). Children in the highest quartile of leptin/adiponectin (L/A) ratio demonstrated significantly higher BMI, systolic blood pressure, hsCRP, triglycerides and fasting glucose and the lowest high density lipoprotein (HDL) compared to lower L/A ratio quartiles.

Conclusions: Alterations in plasma leptin and adiponectin may help to reclassify non-obese children, detecting those with more unfavorable risk profiles independent of BMI status.


Corresponding author: Dimitrios A. Stakos, Assistant Professor of Cardiology, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, 68100, Greece, Phone: +30 25510 74291, Fax: +30 25510 76245, E-mail:

Acknowledgments

We would like to thank Dr George Chalikias for his valuable contribution to the analysis of the data and graphic presentation.

Conflict of interest statement:

The authors declare that they have no conflict of interest.

References

1. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, et al. Prevalence of overweight and obesity in the United States, 1999–2004. J Am Med Assoc 2006;295:1549–55.Search in Google Scholar

2. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, et al. Obesity and the metabolic syndrome in children and adolescents. N Engl J Med 2004;350:2362–74.Search in Google Scholar

3. Hannon TS, Rao G, Arslanian SA. Childhood obesity and type 2 diabetes mellitus. Pediatrics 2005;116:473–80.Search in Google Scholar

4. Romero-Corral A, Somers VK, Sierra-Johnson J, Korenfeld Y, Boarin S, et al. Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality. Eur Heart J 2010;31:737–46.Search in Google Scholar

5. Steinberger J, Daniels SR, Eckel RH, Hayman L, Lustig RH, et al. Progress and challenges in metabolic syndrome in children and adolescents: a scientific statement from the American Heart Association Atherosclerosis, Hypertension, and Obesity in the Young Committee of the Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; and Council on Nutrition, Physical Activity, and Metabolism. Circulation 2009;119:628–47.Search in Google Scholar

6. Jéquier E. Leptin signaling, adiposity, and energy balance. Lipids and insulin resistance: the role of fatty acid metabolism and fuel partitioning. Ann NY Acad Sci 2002;967:379–88.Search in Google Scholar

7. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 2002;8:731–7.Search in Google Scholar

8. Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, et al. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 2001;50:1126–33.Search in Google Scholar

9. Matsuzawa Y, Funahashi T, Nakamura T. Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann NY Acad Sci 1999;892:146–54.Search in Google Scholar

10. Leyva F, Godsland IF, Ghatei M, Proudler AJ, Aldis S, et al. Hyperleptinemia as a component of a metabolic syndrome of cardiovascular risk. Arterioscler Thromb Vasc Biol 1998;18:928–33.Search in Google Scholar

11. Okamoto Y, Kihara S, Funahashi T, Matsuzawa Y, Libby P. Adiponectin: a key adipocytokine in metabolic syndrome. Clin Sci 2006;110:267–78.Search in Google Scholar

12. Ogden CL, Carroll MD, Flegal KM. High body mass index for age among US children and adolescents, 2003–2006. J Am Med Assoc 2008;299:2401–5.Search in Google Scholar

13. Miller M, Stone NJ, Ballantyne C, Bittner V, Criqui MH, et al. Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association. Circulation 2011;123:2292–333.Search in Google Scholar

14. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114:555–76.Search in Google Scholar

15. Zimmet P, Alberti KG, Kaufman F, Tajima N, Silink M, et al. The metabolic syndrome in children and adolescents – an IDF consensus report. Pediatr Diabetes 2007;8:299–306.Search in Google Scholar

16. Jolliffe CJ, Janssen I. Development of age-specific adolescent metabolic syndrome criteria that are linked to the adult treatment panel III and International Diabetes Federation criteria. J Am Coll Cardiol 2007;49:891–8.Search in Google Scholar

17. Shaibi GQ, Cruz ML, Weigensberg MJ, Toledo-Corral CM, Lane CJ, et al. Adiponectin independently predicts metabolic syndrome in overweight Latino youth. J Clin Endocrinol Metab 2007;92:1809–13.Search in Google Scholar

18. Gilardini L, McTernan PG, Girola A, da Silva NF, Alberti L, et al. Adiponectin is a candidate marker of metabolic syndrome in obese children and adolescents. Atherosclerosis 2006;189:401–407.Search in Google Scholar

19. Valle M, Martos R, Gascón F, Cañete R, Zafra MA, et al. Low-grade systemic inflammation, hypoadiponectinemia and a high concentration of leptin are present in very young obese children, and correlate with metabolic syndrome. Diabetes Metab 2005;31:55–62.Search in Google Scholar

20. Papoutsakis C, Yannakoulia M, Ntalla I, Dedoussis GV. Metabolic syndrome in a Mediterranean pediatric cohort: prevalence using International Diabetes Federation-derived criteria and associations with adiponectin and leptin. Metabolism 2012;61:140–5.Search in Google Scholar

21. Nishina M, Kikuchi T, Yamazaki H, Kameda K, Hiura M, et al. Relationship among systolic blood pressure, serum insulin and leptin, and visceral fat accumulation in obese children. Hypertens Res 2003;26:281–8.Search in Google Scholar

22. Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, et al. Plasma leptin levels in healthy children and adolescents: dependence of body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab 1997;82:2904–10.Search in Google Scholar

23. Fleisch AF, Agarwal N, Roberts MD, Han JC, Theim KR, et al. Influence of serum leptin on weight and body fat growth in children at high risk for adult obesity. J Clin Endocrinol Metab 2007;92:948–54.Search in Google Scholar

24. Oda N, Imamura S, Fujita T, Uchida Y, Inagaki K, et al. The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metabolism 2008;57:268–73.Search in Google Scholar

25. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. Low-grade systemic inflammation in overweight children. Pediatrics 2001;107:E13.Search in Google Scholar

26. Chen K, Li F, Li J, Cai H, Strom S, et al. Induction of leptin resistance through direct interaction of C-reactive protein with leptin. Nat Med 2006;12:425–32.Search in Google Scholar

27. Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, et al. Leptin regulates proinflammatory immune responses. FASEB J 1998;12:57–65.Search in Google Scholar

28. Järvisalo MJ, Harmoinen A, Hakanen M, Paakkunainen U, Viikari J, et al. Elevated serum C-reactive protein levels and early arterial changes in healthy children. Arterioscler Thromb Vasc Biol 2002;22:1323–8.Search in Google Scholar

29. Kowalska I, Straczkowski M, Nikolajuk A, Adamska A, Karczewska-Kupczewska M, et al. Insulin resistance, serum adiponectin, and proinflammatory markers in young subjects with the metabolic syndrome. Metabolism 2008;57:1539–44.Search in Google Scholar

30. Oliveira AC, Oliveira AM, Almeida MS, Silva AM, Adan L, et al. Alanine aminotransferase and high sensitivity C-reactive protein: correlates of cardiovascular risk factors in youth. J Pediatr 2008;152:337–42.Search in Google Scholar

31. Singhal A, Farooqi IS, Cole TJ, O’Rahilly S, Fewtrell M, et al. Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease? Circulation 2002;106:1919–24.Search in Google Scholar

32. Emerging Risk Factors Collaboration, Sarwar N, Gao P, Seshasai SR, et al. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 2010;375:2215–22.Search in Google Scholar

33. Lawes CM, Parag V, Bennett DA, Suh I, Lam TH, et al. Blood glucose and risk of cardiovascular disease in the Asia Pacific region. Diabetes Care 2004;27:2836–42.Search in Google Scholar

Received: 2013-5-19
Accepted: 2013-9-11
Published Online: 2013-10-23
Published in Print: 2014-03-01

©2014 by Walter de Gruyter Berlin Boston

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