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The relationship between thyroid dose and diagnosis of primary hypothyroidism in pediatric brain tumor patients receiving craniospinal irradiation

  • Christine Lauro EMAIL logo , Margaret E. Macy , Philip Zeitler , Jennifer Backus , Pamela Mettler , Nicholas Foreman and Arthur K. Liu
Published/Copyright: September 20, 2013
Journal of Pediatric Endocrinology and Metabolism
From the journal Journal of Pediatric Endocrinology and Metabolism Volume 27 Issue 3-4

Abstract

Purpose: The aim of this work is to determine if a relationship exists between thyroid dose and incidence of primary hypothyroidism (PH) in children undergoing craniospinal irradiation (CSI).

Methods: A total of 22 patients received CSI with evaluable thyroid dose information. All patients received concurrent chemotherapy and 21 patients (95%) received adjuvant chemotherapy. Median follow-up was 42.9 months.

Results: The incidence of PH in our cohort was 59% at a median time after radiotherapy of 3.5 years (range: 8 months to 7.5 years). Mean thyroid dose appeared to best predict for PH, with a median of 2080 cGy for patients with PH versus 1736 cGy for children without PH (p=0.057). There was no association between the rate of PH and sex, age, CSI dose, minimum thyroid dose and maximum thyroid dose.

Conclusions: A relationship may exist between the mean thyroid dose and incidence of PH in patients undergoing CSI. Thus, new strategies to protect the thyroid gland may be warranted.

Keywords: children; craniospinal irradiation; hypothyroidism; late effects; medulloblastoma
Corresponding author: Christine Lauro, MD, University of Colorado-Radiation Oncology, Mail Stop F706 1665 Aurora Court, Suite 1032, Aurora, CO 80045, USA, Phone: +1-720-848-0106, Fax: +1-720-848-0222, E-mail:

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Received: 2013-2-25
Accepted: 2013-8-20
Published Online: 2013-09-20
Published in Print: 2014-03-01

©2014 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/jpem-2013-0063
Keywords for this article
children; craniospinal irradiation; hypothyroidism; late effects; medulloblastoma

Articles in the same Issue

  1. Masthead
  2. Masthead
  3. Images in pediatric endocrinology
  4. Leprechaunism (Donohue syndrome): report of a case in a newborn
  5. Original articles
  6. Children and adolescents with type 1 diabetes in Germany are more overweight than healthy controls: results comparing DPV database and CrescNet database
  7. Age of onset of pubertal maturation of Thai boys
  8. Plasma leptin and adiponectin concentrations correlate with cardiometabolic risk and systemic inflammation in healthy, non-obese children
  9. Early differentiation between good and poor response to growth hormone therapy in short children born small for gestational age (SGA) to improve the outcome of poor responders
  10. Children and adolescents with type 1 diabetes mellitus have a sixfold greater risk for prolonged QTc interval
  11. Effect of micronutrient supplementation on height velocity of underprivileged girls in comparison with un-supplemented healthy controls
  12. Insulin resistance in young adults born small for gestational age (SGA)
  13. The effect of childhood obesity on cardiac functions
  14. Adiponectin serum concentrations in newborn at delivery appear to be of fetal origin
  15. Thalassaemic Osteopathy: a cross-sectional preliminary study from Sri Lanka
  16. Health-related quality of life in Turner syndrome and the influence of key features
  17. Clinical analysis on 33 patients with hypothalamic syndrome in Chinese children
  18. The relationship between thyroid dose and diagnosis of primary hypothyroidism in pediatric brain tumor patients receiving craniospinal irradiation
  19. Molecular characterization of Chilean patients with a clinical diagnosis of Noonan syndrome
  20. Expensive therapies in children: benefit versus cost of combined treatment of recombinant human growth hormone and gonadotropin-releasing hormone analogue in girls with poor height potential
  21. The absence of mutations in homeobox candidate genes HOXA3, HOXB3, HOXD3 and PITX2 in familial and sporadic thyroid hemiagenesis
  22. A truncating DUOX2 mutation (R434X) causes severe congenital hypothyroidism
  23. Heterozygous GHR gene mutation in a child with idiopathic short stature
  24. A novel compound mutation of CYP27B1 in a Chinese family with vitamin D-dependent rickets type 1A
  25. A de novo mutation of DAX1 in a boy with congenital adrenal hypoplasia without hypogonadotropic hypogonadism
  26. Patient reports
  27. Hypercalcemia and osteolytic lesions as presenting symptoms of acute lymphoblastic leukemia in childhood. The use of zoledronic acid and review of the literature
  28. Preterm ovarian hyperstimulation syndrome presented with vaginal bleeding: a case report
  29. Pituitary stalk lesion in a 13-year-old female
  30. Radiologic manifestation of a BCS1L-mutated patient
  31. Permanent neonatal diabetes mellitus caused by a novel mutation in the KCNJ11 gene
  32. NKX2-1 mutations in brain-lung-thyroid syndrome: a case series of four patients
  33. A teenage boy with hypocalcemia after radioablation for Graves’ disease
  34. Short communication
  35. A common thyroid peroxidase gene mutation (G319R) in Turkish patients with congenital hypothyroidism could be due to a founder effect
  36. Letter to the Editor
  37. Endometriosis and migraine: what is there behind the scenes?
  38. 10.1515/jpem-2014-0999
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