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Children and adolescents with type 1 diabetes mellitus have a sixfold greater risk for prolonged QTc interval

  • Assimina Galli-Tsinopoulou EMAIL logo , Aikaterini Chatzidimitriou , Ioannis Kyrgios , Israel Rousso , George Varlamis und Kyriaki Karavanaki
Veröffentlicht/Copyright: 14. Oktober 2013
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 27 Heft 3-4

Abstract

Background: QT-wave abnormalities have been detected in type 1 diabetes mellitus (T1DM). Prolongation of the heart rate corrected QT interval (QTc) has been associated with cardiovascular mortality. We evaluated how often QT/QTc abnormalities are present in youth with T1DM and if they are associated with disease parameters.

Methods: Sixty-two T1DM youngsters and equal age- and gender-matched controls were studied. Demographic, anthropometric, and laboratory data were determined. QT was measured on a 12-lead resting electrocardiogram. QTc was calculated using Bazett’s formula.

Results: T1DM patients had significantly longer QT/QTc than controls, but significance disappeared after adjustment for confounders. Abnormally prolonged QTc≥440 ms was observed six times more frequently in those with T1DM. QT was correlated with age, age at disease onset, but not with glycated hemoglobin or diabetes duration; QTc was only correlated with pubertal stage.

Conclusions: T1DM youths have a sixfold increased risk for QT/QTc prolongation and should have regular follow-up for cardiac autonomic dysfunction.

Keywords: children and adolescents; electrocardiographic abnormalities; QTc interval; QT interval; type 1 diabetes mellitus
Corresponding author: Assimina Galli-Tsinopoulou, Faculty of Medicine, 4th Department of Pediatrics, Aristotle University of Thessaloniki, Papageorgiou General Hospital, Ring Road Nea Efkarpia, 564 03 Thessaloniki, Greece, Phone: +30 2310 991537, Fax: +30 2310 991537, E-mail:

Acknowledgments

The study was supported by the Research Committee of the Aristotle University of Thessaloniki (Project: Postgraduate. course “Adolescent medicine,” code project 83023, Principal Investigator: Assistant Professor Assimina Galli-Tsinopoulou). The authors thank all children and adolescents who participated in the study as well as their parents/guardians.

Conflict of interest statement

The authors have no conflicts of interest to disclose.

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Received: 2013-5-18
Accepted: 2013-9-11
Published Online: 2013-10-14
Published in Print: 2014-03-01

©2014 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/jpem-2013-0193
Schlagwörter für diesen Artikel
children and adolescents; electrocardiographic abnormalities; QTc interval; QT interval; type 1 diabetes mellitus

Artikel in diesem Heft

  1. Masthead
  2. Masthead
  3. Images in pediatric endocrinology
  4. Leprechaunism (Donohue syndrome): report of a case in a newborn
  5. Original articles
  6. Children and adolescents with type 1 diabetes in Germany are more overweight than healthy controls: results comparing DPV database and CrescNet database
  7. Age of onset of pubertal maturation of Thai boys
  8. Plasma leptin and adiponectin concentrations correlate with cardiometabolic risk and systemic inflammation in healthy, non-obese children
  9. Early differentiation between good and poor response to growth hormone therapy in short children born small for gestational age (SGA) to improve the outcome of poor responders
  10. Children and adolescents with type 1 diabetes mellitus have a sixfold greater risk for prolonged QTc interval
  11. Effect of micronutrient supplementation on height velocity of underprivileged girls in comparison with un-supplemented healthy controls
  12. Insulin resistance in young adults born small for gestational age (SGA)
  13. The effect of childhood obesity on cardiac functions
  14. Adiponectin serum concentrations in newborn at delivery appear to be of fetal origin
  15. Thalassaemic Osteopathy: a cross-sectional preliminary study from Sri Lanka
  16. Health-related quality of life in Turner syndrome and the influence of key features
  17. Clinical analysis on 33 patients with hypothalamic syndrome in Chinese children
  18. The relationship between thyroid dose and diagnosis of primary hypothyroidism in pediatric brain tumor patients receiving craniospinal irradiation
  19. Molecular characterization of Chilean patients with a clinical diagnosis of Noonan syndrome
  20. Expensive therapies in children: benefit versus cost of combined treatment of recombinant human growth hormone and gonadotropin-releasing hormone analogue in girls with poor height potential
  21. The absence of mutations in homeobox candidate genes HOXA3, HOXB3, HOXD3 and PITX2 in familial and sporadic thyroid hemiagenesis
  22. A truncating DUOX2 mutation (R434X) causes severe congenital hypothyroidism
  23. Heterozygous GHR gene mutation in a child with idiopathic short stature
  24. A novel compound mutation of CYP27B1 in a Chinese family with vitamin D-dependent rickets type 1A
  25. A de novo mutation of DAX1 in a boy with congenital adrenal hypoplasia without hypogonadotropic hypogonadism
  26. Patient reports
  27. Hypercalcemia and osteolytic lesions as presenting symptoms of acute lymphoblastic leukemia in childhood. The use of zoledronic acid and review of the literature
  28. Preterm ovarian hyperstimulation syndrome presented with vaginal bleeding: a case report
  29. Pituitary stalk lesion in a 13-year-old female
  30. Radiologic manifestation of a BCS1L-mutated patient
  31. Permanent neonatal diabetes mellitus caused by a novel mutation in the KCNJ11 gene
  32. NKX2-1 mutations in brain-lung-thyroid syndrome: a case series of four patients
  33. A teenage boy with hypocalcemia after radioablation for Graves’ disease
  34. Short communication
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  36. Letter to the Editor
  37. Endometriosis and migraine: what is there behind the scenes?
  38. 10.1515/jpem-2014-0999
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