Startseite The relationship between adiposity and stature in prepubertal children with celiac disease
Artikel
Lizenziert
Nicht lizenziert Erfordert eine Authentifizierung

The relationship between adiposity and stature in prepubertal children with celiac disease

  • Benjamin Udoka Nwosu EMAIL logo , Rachel I. Snook und Louise Maranda
Veröffentlicht/Copyright: 24. Mai 2013
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 26 Heft 9-10

Abstract

Background and aim: The pathogenesis of short stature in celiac disease (CD) is unknown. Obese children are generally taller than their non-obese peers; however, the role of adiposity on stature in CD is unclear. Our aim was to determine the association between adiposity and stature in CD.

Subjects and methods: We compared the anthropometric characteristics of prepubertal children of ages 3–12 years, with biopsy-proven CD (n=40) and who were not on gluten-free diet, to same aged, prepubertal non-CD children (n=50). Body mass index (BMI) was calculated using the formula weight/height2. Sex-adjusted midparental target height (MPTH) standard deviation score (SDS) was calculated using National Children Health Statistics data for 18-year-old adults. Data were expressed as mean±standard deviation.

Results: CD subjects had significantly lower BMI SDS than controls (0.61±1.22 vs. 1.28±1.60, p=0.027) but were not significantly shorter than the controls (–0.05±1.21 vs. 0.21±1.71, p=0.41). When the patients were subdivided into the normal-weight and overweight/obese groups, the normal-weight CD patients were of similar height as the normal-weight controls (p=0.76) but were significantly shorter than both the overweight/obese controls (p<0.001) and overweight/obese CD children (p<0.001). Interestingly, the overweight/obese CD children were significantly taller than the normal-weight controls (p=0.003). The MPTH SDS did not differ between the groups.

Conclusions: Overweight/obese prepubertal children with CD were taller than both their normal-weight CD peers and the normal-weight controls, but were of similar height as the overweight/obese control subjects.

Keywords: celiac disease; obesity; stature
Corresponding author: Benjamin U. Nwosu, MD, Associate Professor, Division of Endocrinology, Department of Pediatrics, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA, Phone: +508-334-7872, Fax: +508-856-4287, E-mail:

This study was supported in part by a grant to Benjamin U. Nwosu from the Department of Pediatrics and the Faculty Diversity Scholars Program, University of Massachusetts Medical School, Worcester, MA. BUN is a member of the UMass Diabetes and Endocrine Research Center (DK32520). We thank Mr. Francis M. Wanjau for his help with data management.

References

1. Fasano A. Should we screen for coeliac disease? Yes. Br Med J 2009;339:b3592.10.1136/bmj.b3592Suche in Google Scholar

2. Corazza GR, Di Sario A, Sacco G, Zoli G, Treggiari EA, et al. Subclinical coeliac disease: an anthropometric assessment. J Intern Med 1994;236:183–7.10.1111/j.1365-2796.1994.tb01281.xSuche in Google Scholar

3. Valletta E, Fornaro M, Cipolli M, Conte S, Bissolo F, et al. Celiac disease and obesity: need for nutritional follow-up after diagnosis. Eur J Clin Nutr 2010;64:1371–2.10.1038/ejcn.2010.161Suche in Google Scholar

4. Telega G, Bennet TR, Werlin S. Emerging new clinical patterns in the presentation of celiac disease. Arch Pediatr Adolesc Med 2008;162:164–8.10.1001/archpediatrics.2007.38Suche in Google Scholar

5. Venkatasubramani N, Szabo S, Werlin SL. Autoimmune hepatitis in a child with chronic hepatitis B virus infection. J Pediatr Gastroenterol Nutr 2009;49:639–41.10.1097/MPG.0b013e3181903fbdSuche in Google Scholar

6. Reilly NR, Aguilar K, Hassid BG, Cheng J, Defelice AR, et al. Celiac disease in normal-weight and overweight children: clinical features and growth outcomes following a gluten-free diet. J Pediatr Gastroenterol Nutr 2011;53:528–31.10.1097/MPG.0b013e3182276d5eSuche in Google Scholar

7. Venkatasubramani N, Telega G, Werlin SL. Obesity in pediatric celiac disease. J Pediatr Gastroenterol Nutr 2010;51:295–7.10.1097/MPG.0b013e3181d1365aSuche in Google Scholar

8. Verkasalo M, Kuitunen P, Leisti S, Perheentupa J. Growth failure from symptomless celiac disease: a study of 14 patients. Helv Paediatr Acta 1978;33:489–95.Suche in Google Scholar

9. Bottaro G, Cataldo F, Rotolo N, Spina M, Corazza GR. The clinical pattern of subclinical/silent celiac disease: an analysis on 1026 consecutive cases. Am J Gastroenterol 1999;94:691–6.10.1016/S0002-9270(98)00819-3Suche in Google Scholar

10. Meazza C, Pagani S, Laarej K, Cantoni F, Civallero P, et al. Short stature in children with coeliac disease. Pediatr Endocrinol Rev 2009;6:457–63.Suche in Google Scholar

11. Assiri AM. Isolated short stature as a presentation of celiac disease in Saudi children. Pediatr Rep 2010;2:e4.10.4081/pr.2010.e4Suche in Google Scholar PubMed PubMed Central

12. Vanderschueren L, Wolter R, Molla A, Eggermont E, Eeckels R. Plasma growth hormone in coeliac disease. Helv Paediatr Acta 1973;28:349–57.Suche in Google Scholar

13. Peracchi M, Molteni N, Cantalamessa L, Bardella MT, Peracchi G, et al. Abnormal growth hormone responsiveness to stimuli in women with active celiac sprue. Am J Gastroenterol 1992;87:580–3.Suche in Google Scholar

14. Lecornu M, David L, Francois R. Low serum somatomedin activity in celiac disease: a misleading aspect in growth failure from asymptomatic celiac disease. Helv Paediatr Acta 1978;33: 509–16.Suche in Google Scholar

15. Bresson JL, Prevot C, Rappaport R, Czernichow P, Schmitz J, et al. [Circulating somatomedin activity and growth hormone secretion: changes during late diagnosed celiac disease and effects of treatment]. Arch Fr Pediatr 1979;36:XIII–VIII.Suche in Google Scholar

16. Federico G, Favilli T, Cinquanta L, Ughi C, Saggese G. Effect of celiac disease and gluten-free diet on growth hormone-binding protein, insulin-like growth factor-I, and insulin-like growth factor-binding proteins. Horm Res 1997;48:108–14.10.1159/000185499Suche in Google Scholar PubMed

17. Dickey W, Kearney N. Overweight in celiac disease: prevalence, clinical characteristics, and effect of a gluten-free diet. Am J Gastroenterol 2006;101:2356–9.10.1111/j.1572-0241.2006.00750.xSuche in Google Scholar PubMed

18. Owen DA, Thorlakson TK, Walli JE. Celiac disease in a patient with morbid obesity. Arch Intern Med 1980;140:1380–1.10.1001/archinte.1980.00330210128039Suche in Google Scholar

19. Semeraro LA, Barwick KW, Gryboski JD. Obesity in celiac sprue. J Clin Gastroenterol 1986;8:177–80.10.1097/00004836-198604000-00015Suche in Google Scholar PubMed

20. Conti Nibali S, Magazzu G, De Luca F. Obesity in a child with untreated coeliac disease. Helv Paediatr Acta 1987;42:45–8.Suche in Google Scholar

21. Czaja-Bulsa G, Garanty-Bogacka B, Syrenicz M, Gebala A. Obesity in an 18-year-old boy with untreated celiac disease. J Pediatr Gastroenterol Nutr 2001;32:226.10.1097/00005176-200102000-00031Suche in Google Scholar PubMed

22. Franzese A, Iannucci MP, Valerio G, Ciccimarra E, Spaziano M, et al. Atypical celiac disease presenting as obesity-related liver dysfunction. J Pediatr Gastroenterol Nutr 2001;33:329–32.10.1097/00005176-200109000-00019Suche in Google Scholar PubMed

23. Shalitin S, Phillip M. Role of obesity and leptin in the pubertal process and pubertal growth – a review. Int J Obes Relat Metab Disord 2003;27:869–74.10.1038/sj.ijo.0802328Suche in Google Scholar PubMed

24. Lustig RH, Weiss, R. Pediatric endocrinology, 3rd ed. Philadelphia: Saunders, 2008.Suche in Google Scholar

25. Jin L, Burguera BG, Couce ME, Scheithauer BW, Lamsan J, et al. Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of a regulatory role for leptin on pituitary cell proliferation. J Clin Endocrinol Metab 1999;84:2903–11.Suche in Google Scholar

26. Lebrethon MC, Vandersmissen E, Gerard A, Parent AS, Junien JL, et al. In vitro stimulation of the prepubertal rat gonadotropin-releasing hormone pulse generator by leptin and neuropeptide Y through distinct mechanisms. Endocrinology 2000;141:1464–9.10.1210/endo.141.4.7432Suche in Google Scholar PubMed

27. Yu WH, Kimura M, Walczewska A, Karanth S, McCann SM. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA 1997;94:1023–8.10.1073/pnas.94.3.1023Suche in Google Scholar PubMed PubMed Central

28. Maor GR, Segev Y, Phillip M. Leptin acts as a growth factor on the chondrocytes of skeletal growth centers. J Bone Miner Res 2002;17:1034–43.10.1359/jbmr.2002.17.6.1034Suche in Google Scholar PubMed

29. Biason-Lauber A, Zachmann M, Schoenle EJ. Effect of leptin on CYP17 enzymatic activities in human adrenal cells: new insight in the onset of adrenarche. Endocrinology 2000;141:1446–54.10.1210/endo.141.4.7402Suche in Google Scholar PubMed

30. Genazzani AR, Pintor C, Corda R. Plasma levels of gonadotropins, prolactin, thyroxine, and adrenal and gonadal steroids in obese prepubertal girls. J Clin Endocrinol Metab 1978;47:974–9.10.1210/jcem-47-5-974Suche in Google Scholar

31. De Simone M, Farello G, Palumbo M, Gentile T, Ciuffreda M, et al. Growth charts, growth velocity and bone development in childhood obesity. Int J Obes Relat Metab Disord 1995;19:851–7.Suche in Google Scholar

32. Ravelli A, Bolognini S, Gambarotti M, Villanacci V. Variability of histologic lesions in relation to biopsy site in gluten-sensitive enteropathy. Am J Gastroenterol 2005;100:177–85.10.1111/j.1572-0241.2005.40669.xSuche in Google Scholar

33. Kav T, Sivri B. Is enteroscopy necessary for diagnosis of celiac disease? World J Gastroenterol 2012;18:4095–101.10.3748/wjg.v18.i31.4095Suche in Google Scholar

34. Hill ID, Dirks MH, Liptak GS, Colletti RB, Fasano A, et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2005;40:1–19.10.1097/00005176-200501000-00001Suche in Google Scholar

35. Barlow SE. Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report. Pediatrics 2007;120(Suppl 4):S164–92.10.1542/peds.2007-2329CSuche in Google Scholar

36. Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, et al. 2000 CDC Growth Charts for the United States: methods and development. Vital Health Stat 11 2002:1–190.Suche in Google Scholar

37. Wales JK, Wit J-M, Rogol AD. Pediatric endocrinology and growth, 2nd ed. New York: Saunders Scientific Publications, 2002.Suche in Google Scholar

38. Killeen J, Vanderburg D, Harlan WR. Application of weight-height ratios and body indices to juvenile populations – the National Health Examination Survey Data. J Chronic Dis 1978;31: 529–37.10.1016/0021-9681(78)90040-1Suche in Google Scholar

39. Himes JH, Roche AF. Subcutaneous fatness and stature: relationship from infancy to adulthood. Hum Biol 1986;58: 737–50.Suche in Google Scholar

40. Lazarus R, Baur L, Webb K, Blyth F. Adiposity and body mass indices in children: Benn’s index and other weight for height indices as measures of relative adiposity. Int J Obes Relat Metab Disord 1996;20:406–12.Suche in Google Scholar

41. Hattori K, Hirohara T. Age change of power in weight/height(p) indices used as indicators of adiposity in Japanese. Am J Hum Biol 2002;14:275–9.10.1002/ajhb.10037Suche in Google Scholar PubMed

42. Freedman DS, Thornton JC, Mei Z, Wang J, Dietz WH, et al. Height and adiposity among children. Obes Res 2004;12:846–53.10.1038/oby.2004.102Suche in Google Scholar PubMed

43. Cheng J, Brar PS, Lee AR, Green PH. Body mass index in celiac disease: beneficial effect of a gluten-free diet. J Clin Gastroenterol 2010;44:267–71.10.1097/MCG.0b013e3181b7ed58Suche in Google Scholar PubMed

44. Ertekin V, Orbak Z, Selimoglu MA, Yildiz L. Serum leptin levels in childhood celiac disease. J Clin Gastroenterol 2006;40:906–9.10.1097/01.mcg.0000225513.20913.6aSuche in Google Scholar PubMed

45. Maccario M, Ramunni J, Oleandri SE, Procopio M, Grottoli S, et al. Relationships between IGF-I and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients. Int J Obes Relat Metab Disord 1999;23:612–8.10.1038/sj.ijo.0800889Suche in Google Scholar PubMed

Received: 2012-10-4
Accepted: 2013-4-15
Published Online: 2013-05-24
Published in Print: 2013-10-01

©2013 by Walter de Gruyter Berlin Boston

Artikel in diesem Heft

  1. Masthead
  2. Masthead
  3. Review article
  4. Tamoxifen therapy for the management of pubertal gynecomastia: a systematic review
  5. Images in pediatric endocrinology
  6. Solitary median maxillary central incisor, a clinical predictor of hypoplastic anterior pituitary, ectopic neurohypophysis and growth hormone deficiency
  7. A rare case of granuloma annulare in a 6-year-old child with type 1 diabetes
  8. Original articles
  9. The arginine stimulation test: timing of peak is not a helpful parameter in the diagnosis of growth hormone deficiency
  10. The relationship between adiposity and stature in prepubertal children with celiac disease
  11. Influence of micronutrient status and socioeconomic gradient on growth indices of 2–18-year-old Indian girls
  12. Phosphotyrosine phosphatases in GH-stimulated skin fibroblasts from children with idiopathic short stature
  13. The relation between salivary cortisol and the metabolic syndrome score in girls
  14. Association of vitamin D concentrations with adiposity indices among preadolescent children in Korea
  15. Association of serum resistin levels with metabolic syndrome and early atherosclerosis in obese Chinese children
  16. Characteristics of infants at risk of hypoglycaemia secondary to being ‘infant of a diabetic mother’
  17. Parental dyadic coping in families of children and adolescents with type 1 diabetes
  18. Pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) syndrome is associated with severe chronic inflammation and cardiomyopathy, and represents a new monogenic autoinflammatory syndrome
  19. Effect of insulin therapy on IGF-1 level in children with new-onset type 1 diabetes mellitus: a comparison between DKA and non-DKA
  20. Mutation analysis of the SRD5A2, AR and SF-1 genes in 52 Chinese boys with hypospadias
  21. Sexual development in prepubertal obese boys: a 4-year longitudinal study
  22. Genetic diagnosis of one family with incomplete clinical data
  23. Patient reports
  24. Complete androgen insensitivity syndrome and discordant Müllerian remnants: two cases with novel mutation in the androgen receptor
  25. Psychosexual outcomes in three siblings with partial androgen insensitivity syndrome: impact of nature versus nurture
  26. Ambiguous genitalia in a 48, XXYY newborn: a casual relationship or a coincidence?
  27. Gonadal function of beta-thalassemics following stem cell transplantation conditioned with myeloablative and reduced intensity regimens
  28. Significant testicular enlargement in a 6.5-year-old boy with monorchism and testicular microlithiasis
  29. Report of the first case of precocious puberty in Rett syndrome
  30. Type II vitamin D-dependent rickets with diabetic ketoacidosis
  31. Pituitary gigantism presenting with depressive mood disorder and diabetic ketoacidosis in an Asian adolescent
  32. A rare association between Rathke’s cyst and hypophysitis in a patient with delayed sex development and growth failure
  33. Diabetes mellitus with Laron syndrome: case report
  34. Wegener granulomatosis as an uncommon cause of panhypopituitarism in childhood
  35. Rare cases of autoimmune hypothyroidism in young children
  36. Cushing syndrome related to leukemic infiltration of the central nervous system: a case report and a possible role of LIF
  37. Early presentation of bilateral gonadoblastomas in a Denys-Drash syndrome patient: a cautionary tale for prophylactic gonadectomy
  38. Identification of a novel homozygous mutation (S144I) in a Malay patient with maple syrup urine disease
  39. Virilization in two pre-pubertal children exposed to topical androgen
  40. A family with Camurati-Engelman disease. The role of the missense p.R218C mutation in TGFB1 in bones and endocrine glands
  41. Short communications
  42. Plasma ceramides are elevated in female children and adolescents with type 2 diabetes
  43. Assessment of contractility and myocardial function in small and appropriate for gestational age premature neonates using the stress-velocity relationship and tissue Doppler imaging immediately after birth
  44. Letter to the Editors
  45. Homeostasis model assessment of insulin resistance may not be reliable to evaluate insulin sensitivity in young obese children
  46. Type 1 diabetes in women with endometriosis: what is the risk of occurrence?
  47. How should we manage vitamin D-deficient adolescents?
  48. Should neonatal hyperparathyroidism associated with mucolipidosis II/III be treated pharmacologically?a
https://doi.org/10.1515/jpem-2012-0312
Schlagwörter für diesen Artikel
celiac disease; obesity; stature

Artikel in diesem Heft

  1. Masthead
  2. Masthead
  3. Review article
  4. Tamoxifen therapy for the management of pubertal gynecomastia: a systematic review
  5. Images in pediatric endocrinology
  6. Solitary median maxillary central incisor, a clinical predictor of hypoplastic anterior pituitary, ectopic neurohypophysis and growth hormone deficiency
  7. A rare case of granuloma annulare in a 6-year-old child with type 1 diabetes
  8. Original articles
  9. The arginine stimulation test: timing of peak is not a helpful parameter in the diagnosis of growth hormone deficiency
  10. The relationship between adiposity and stature in prepubertal children with celiac disease
  11. Influence of micronutrient status and socioeconomic gradient on growth indices of 2–18-year-old Indian girls
  12. Phosphotyrosine phosphatases in GH-stimulated skin fibroblasts from children with idiopathic short stature
  13. The relation between salivary cortisol and the metabolic syndrome score in girls
  14. Association of vitamin D concentrations with adiposity indices among preadolescent children in Korea
  15. Association of serum resistin levels with metabolic syndrome and early atherosclerosis in obese Chinese children
  16. Characteristics of infants at risk of hypoglycaemia secondary to being ‘infant of a diabetic mother’
  17. Parental dyadic coping in families of children and adolescents with type 1 diabetes
  18. Pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) syndrome is associated with severe chronic inflammation and cardiomyopathy, and represents a new monogenic autoinflammatory syndrome
  19. Effect of insulin therapy on IGF-1 level in children with new-onset type 1 diabetes mellitus: a comparison between DKA and non-DKA
  20. Mutation analysis of the SRD5A2, AR and SF-1 genes in 52 Chinese boys with hypospadias
  21. Sexual development in prepubertal obese boys: a 4-year longitudinal study
  22. Genetic diagnosis of one family with incomplete clinical data
  23. Patient reports
  24. Complete androgen insensitivity syndrome and discordant Müllerian remnants: two cases with novel mutation in the androgen receptor
  25. Psychosexual outcomes in three siblings with partial androgen insensitivity syndrome: impact of nature versus nurture
  26. Ambiguous genitalia in a 48, XXYY newborn: a casual relationship or a coincidence?
  27. Gonadal function of beta-thalassemics following stem cell transplantation conditioned with myeloablative and reduced intensity regimens
  28. Significant testicular enlargement in a 6.5-year-old boy with monorchism and testicular microlithiasis
  29. Report of the first case of precocious puberty in Rett syndrome
  30. Type II vitamin D-dependent rickets with diabetic ketoacidosis
  31. Pituitary gigantism presenting with depressive mood disorder and diabetic ketoacidosis in an Asian adolescent
  32. A rare association between Rathke’s cyst and hypophysitis in a patient with delayed sex development and growth failure
  33. Diabetes mellitus with Laron syndrome: case report
  34. Wegener granulomatosis as an uncommon cause of panhypopituitarism in childhood
  35. Rare cases of autoimmune hypothyroidism in young children
  36. Cushing syndrome related to leukemic infiltration of the central nervous system: a case report and a possible role of LIF
  37. Early presentation of bilateral gonadoblastomas in a Denys-Drash syndrome patient: a cautionary tale for prophylactic gonadectomy
  38. Identification of a novel homozygous mutation (S144I) in a Malay patient with maple syrup urine disease
  39. Virilization in two pre-pubertal children exposed to topical androgen
  40. A family with Camurati-Engelman disease. The role of the missense p.R218C mutation in TGFB1 in bones and endocrine glands
  41. Short communications
  42. Plasma ceramides are elevated in female children and adolescents with type 2 diabetes
  43. Assessment of contractility and myocardial function in small and appropriate for gestational age premature neonates using the stress-velocity relationship and tissue Doppler imaging immediately after birth
  44. Letter to the Editors
  45. Homeostasis model assessment of insulin resistance may not be reliable to evaluate insulin sensitivity in young obese children
  46. Type 1 diabetes in women with endometriosis: what is the risk of occurrence?
  47. How should we manage vitamin D-deficient adolescents?
  48. Should neonatal hyperparathyroidism associated with mucolipidosis II/III be treated pharmacologically?a
Jetzt anmelden und 20% sparen
Institutioneller Zugang
Wie funktioniert Authentifizierung?
Haben Sie eine Idee, wie wir unsere Website verbessern können?
Bitte schreiben Sie uns.
© 2025 De Gruyter Brill
Heruntergeladen am 7.9.2025 von https://www.degruyterbrill.com/document/doi/10.1515/jpem-2012-0312/html?lang=de
Button zum nach oben scrollen