Startseite Effect of insulin therapy on IGF-1 level in children with new-onset type 1 diabetes mellitus: a comparison between DKA and non-DKA
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Effect of insulin therapy on IGF-1 level in children with new-onset type 1 diabetes mellitus: a comparison between DKA and non-DKA

  • Siamak Shiva EMAIL logo , Haleh Behbod und Robabeh Ghergherechi
Veröffentlicht/Copyright: 17. Mai 2013
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 26 Heft 9-10

Abstract

Background and objective: The issue of insulin-like growth factor 1 (IGF-1) and diabetes in adults and type 2 diabetes has been well investigated. A few studies have investigated the serum IGF-1 level at the onset of type 1 diabetes mellitus (T1DM) in children. In the present study, we investigated the IGF-1 level of T1DM children before and after insulin therapy.

Subjects and methods: Between August 2011 and October 2012, 62 children with newly diagnosed T1DM were recruited. Serum IGF-1 levels were compared before and 1 month after insulin therapy between diabetic ketoacidosis (DKA) and non-DKA patients.

Results: Thirty-one patients without DKA (18 girls and 13 boys, mean age 8.8±3.01 years) and 31 patients with DKA (18 girls and 13 boys, mean age 8.3±3.7 years) were studied. The mean IGF-1 in the DKA group was lower than that in the non-DKA group; however, this difference was not statistically significant (p=0.10). Serum IGF-1 levels increased significantly 1 month after insulin therapy in both the DKA (p<0.001) and non-DKA (p<0.001) groups.

Conclusion: Serum IGF-1 level is reduced in new-onset T1DM children. A significant increase in serum IGF-1 level can occur with insulin therapy in both DKA and non-DKA children.

Keywords: children; diabetic ketoacidosis; insulin like growth factor 1; newly diagnosed diabetes
Corresponding author: Siamak Shiva, Pediatric Health Research Center, Tabriz Children’s Hospital, Sheshgelan Str, Tabriz 5136735886, IR Iran, Phone: +98 914 4053982, Fax: +98 411 5262280, E-mail:

The authors acknowledge the Pediatric Health Research Center for financial support, the Danesh Pathobiology Center, and Dr. Poorebrahim for the kind cooperation in this project.

References

1. DIAMOND Project Group. Incidence and trends of childhood type 1 diabetes worldwide 1990–1999. Diabet Med 2006;23:857–66.10.1111/j.1464-5491.2006.01925.xSuche in Google Scholar PubMed

2. Wolfsdorf J, Graig M, Daneman D, Dunger D, Edge J, et al. ISPAD clinical practice consensus guidelines 2009. Chapter 10: diabetic ketoacidosis. Pediatr Diabetes 2009;10(Suppl 12):118–33.10.1111/j.1399-5448.2009.00569.xSuche in Google Scholar PubMed

3. Usher-Smith JA, Thompson M, Ercole A, Walter FM. Variations between countries in the frequency of diabetic ketoacidosis at first presentation of type 1 diabetes in children: a systematic review. Diabetologica 2012;55:2878–94.10.1007/s00125-012-2690-2Suche in Google Scholar PubMed PubMed Central

4. Frystyk J. Free insulin-like growth factor – measurements and relationships to growth hormone secretion and glucose homeostasis. Growth Hormone IGF Res 2004;14:337–75.10.1016/j.ghir.2004.06.001Suche in Google Scholar PubMed

5. Chiarelli F, Giannini C, Mohn A. Growth, growth factors and diabetes. Eur J Endocrinol 2004;151:U109–17.10.1530/eje.0.151u109Suche in Google Scholar PubMed

6. Vella A, Bouatina-Naji N, Heude B, Cooper JD, Lowe CE, et al. Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes. Diabetologica 2008;51:811–5.10.1007/s00125-008-0970-7Suche in Google Scholar PubMed PubMed Central

7. Fowlkes JL, Bunn C, Thrailkill KM. Contributions of the insulin/insulin-like growth factor-1 axis to diabetic osteopathy. J Diabetes Metab 2011;S1-003:2155–6.10.4172/2155-6156.S1-003Suche in Google Scholar PubMed PubMed Central

8. Merinee T. The interface between diabetic retinopathy, diabetes management, and insulin-like growth factors. J Clin Endocrinol Metab 1997;82:2806–8.10.1210/jcem.82.9.4265Suche in Google Scholar PubMed

9. Peczynska J, Urban M, Glowinska B, Urban B. Growth hormone, insulin-like growth factor and insulin-like growth factor binding protein in young type 1 diabetes patients with the onset of diabetic angiopathy. Pol Merkur Lekarski 2003;14:336–9.Suche in Google Scholar

10. Muniyappa R, Sowers JR. Endothelial insulin and IGF-1 receptor: when yes means no. Diabetes 2012;61:2225–7.10.2337/db12-0654Suche in Google Scholar PubMed PubMed Central

11. Duarte AI, Petit GH, Ranganathan S, Li JY, Oliveira CR, et al. IGF-1 protects against diabetic features in an in vivo model of Huntington’s disease. Exp Neurol 2011;231:314–9.10.1016/j.expneurol.2011.06.016Suche in Google Scholar PubMed

12. Faerch L, Juul A, Pedersen-Bjergaard U, Thorsteinsson B. Association of IGF1 with glycemic control and occurrence of severe hypoglycemia in patients with type 1 diabetes mellitus. Endocr Connect 2012;1:31–6.10.1530/EC-12-0012Suche in Google Scholar

13. Colao A, Di Somma C, Cascella T, Pivonello R, Vitale G, et al. Relationships between serum IGF1 levels, blood pressure, and glucose tolerance: an observational, exploratory study in 404 subjects. Eur J Endocrinol 2008;159:389–97.10.1530/EJE-08-0201Suche in Google Scholar

14. Schneider HJ, Friedrich N, Klotsche J, Schipf S, Nauck M, et al. Prediction of incident diabetes mellitus by baseline IGF1 levels. Eur J Endocrinol 2011;164:223–9.10.1530/EJE-10-0963Suche in Google Scholar

15. Strasser-Vogel B, Blum WE, Past R, Kessler U, Hoeflich A, et al. Insulin-like growth factor (IGF)-I and II and IGF-binding proteins-1,-2, and-3 in children and adolescents with diabetes mellitus: correlations with metabolic control and height attainment. J Clin Endocrinol Metab 1995;80:1207–13.Suche in Google Scholar

16. Shishko PI, Dreval AV, Abugova IA, Zajarny IU, Goncharov VC. Insulin-like growth factors and binding proteins in patients with recent-onset type 1 (insulin-dependent) diabetes mellitus: influence of diabetes control and intraportal insulin infusion. Diabetes Res Clin Pract 1994;25:1–12.10.1016/0168-8227(94)90155-4Suche in Google Scholar

17. Bereket A, Lang CH, Blethen SL, Gelato MC, Fan J, et al. Effect of insulin on the insulin-like growth factor system in children with new-onset insulin-dependent diabetes mellitus. J Clinendocrinol Metab 1995;80:1312–7.Suche in Google Scholar

18. Kabir G, Hossain M, Faruque MO, Hassan N, Hassan Z, et al. Association of serum free IGF-1 and IGFBP-1 with insulin sensitivity in impaired glucose tolerance (IGT). Int J Diabetes Mellit 2010;2:144–7.10.1016/j.ijdm.2010.09.003Suche in Google Scholar

19. Teppala S, Shankar A. Association between serum IGF-1 and diabetes among U.S. adults. Diabetes Care 2010;33:2257–9.10.2337/dc10-0770Suche in Google Scholar PubMed PubMed Central

20. Yagasaki H, Kobayashi K, Saitou T, Nagamine K, Nitsui Y, et al. Nocturnal blood glucose and IGFBP-1 changes in type 1 diabetes: differences in the dawn phenomenon between insulin regimens. Exp Clin Endocrinol Diabetes 2010;118:195–9.10.1055/s-0029-1239518Suche in Google Scholar PubMed

21. Barg E, Wikiera B, Bieniasz J, Wasikowa R. Estimation of IGF-1 and IGFBP-3 concentrations in serum in children with diabetes type 1 and growth disorders. Endocrinol Diabetol Chor Przemiany Materii Wieku Rozw 2001;7:75–9.Suche in Google Scholar

22. Bereket A, Lang CH, Wilson TA. Alterations in the growth hormone-insulin-like growth factor axis in insulin dependent diabetes mellitus. Horm Metab Res. 1999;31:172–81.10.1055/s-2007-978716Suche in Google Scholar PubMed

23. Cianfarani S, Bonfanti R, Bitti ML, Germani D, Boemi S, et al. Growth and insulin-like growth factors (IGFs) in children with insulin-dependent diabetes mellitus at the onset of disease: evidence for normal growth, age dependency of the IGF system alterations, and presence of a small (approximately 18-kilodalton) IGF-binding protein-3 fragment in serum. J Clin Endocrinol Metab 2000;85:4162–7.10.1210/jcem.85.11.6996Suche in Google Scholar PubMed

24. Clemmons DR. The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity. J Clin Invest 2004;113:25–7.10.1172/JCI20660Suche in Google Scholar PubMed PubMed Central

25. Sesti G, Sciacqua A, Cardellini M, Marini MA, Maio R, et al. Plasma concentration of IGF-I is independently associated with insulin sensitivity in subjects with different degrees of glucose tolerance. Diabetes Care 2005;28:120–5.10.2337/diacare.28.1.120Suche in Google Scholar PubMed

26. Mohamed-Ali V, Pinkney J. Therapeutic potential of insulin-like growth factor-1 in patients with diabetes mellitus. Treat Endocrinol 2002;1:399–410.10.2165/00024677-200201060-00005Suche in Google Scholar PubMed

Received: 2013-2-10
Accepted: 2013-4-22
Published Online: 2013-05-17
Published in Print: 2013-10-01

©2013 by Walter de Gruyter Berlin Boston

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https://doi.org/10.1515/jpem-2013-0057
Schlagwörter für diesen Artikel
children; diabetic ketoacidosis; insulin like growth factor 1; newly diagnosed diabetes

Artikel in diesem Heft

  1. Masthead
  2. Masthead
  3. Review article
  4. Tamoxifen therapy for the management of pubertal gynecomastia: a systematic review
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  6. Solitary median maxillary central incisor, a clinical predictor of hypoplastic anterior pituitary, ectopic neurohypophysis and growth hormone deficiency
  7. A rare case of granuloma annulare in a 6-year-old child with type 1 diabetes
  8. Original articles
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  10. The relationship between adiposity and stature in prepubertal children with celiac disease
  11. Influence of micronutrient status and socioeconomic gradient on growth indices of 2–18-year-old Indian girls
  12. Phosphotyrosine phosphatases in GH-stimulated skin fibroblasts from children with idiopathic short stature
  13. The relation between salivary cortisol and the metabolic syndrome score in girls
  14. Association of vitamin D concentrations with adiposity indices among preadolescent children in Korea
  15. Association of serum resistin levels with metabolic syndrome and early atherosclerosis in obese Chinese children
  16. Characteristics of infants at risk of hypoglycaemia secondary to being ‘infant of a diabetic mother’
  17. Parental dyadic coping in families of children and adolescents with type 1 diabetes
  18. Pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) syndrome is associated with severe chronic inflammation and cardiomyopathy, and represents a new monogenic autoinflammatory syndrome
  19. Effect of insulin therapy on IGF-1 level in children with new-onset type 1 diabetes mellitus: a comparison between DKA and non-DKA
  20. Mutation analysis of the SRD5A2, AR and SF-1 genes in 52 Chinese boys with hypospadias
  21. Sexual development in prepubertal obese boys: a 4-year longitudinal study
  22. Genetic diagnosis of one family with incomplete clinical data
  23. Patient reports
  24. Complete androgen insensitivity syndrome and discordant Müllerian remnants: two cases with novel mutation in the androgen receptor
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