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Evaluation of neutrophil gelatinase-associated lipocalin in normoalbuminuric normotensive type 1 diabetic adolescents
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Korcan Demir
Published/Copyright:
May 10, 2012
Abstract
Aims: The aims of this study were to determine neutrophil gelatinase-associated lipocalin (NGAL) levels in normoalbuminuric and normotensive adolescents with type 1 diabetes and to assess the relationship between NGAL and clinical and laboratory variables.
Methods: Forty-six adolescents with type 1 diabetes [male/female (M/F) ratio, 24/22; median age, 14.5 years; range, 12.2–16 years; diabetes duration, 4.8 years; range, 2.6–6.7 years; hemoglobin A1c (HbA1c), 7.9%; range, 7.2%–9.2%] and 21 healthy controls (M/F, 7/14; median age, 14.8 years; range, 13.6–15.5 years) were compared regarding clinical, laboratory, and ambulatory blood pressure monitoring variables.
Results: Median blood and urine glucose, HbA1c, urine NGAL/creatinine ratio [13.2 (range, 8.3–43.1) vs. 4.8 (range, 2.9–20.2), p=0.015], and daytime systolic and diastolic blood pressure (BP) standard deviation score and BP loads were found higher in diabetic adolescents. Urine NGAL levels were found to be correlated with albumin/creatinine ratio (r=0.452, p=0.002), whereas plasma NGAL levels were correlated with nighttime systolic BP load (r=0.309, p=0.037). Patients with high-normal albuminuria (n=6) had higher urine NGAL levels [48.7 ng/mL (range, 27.9–149.1 ng/mL) vs. 14.3 ng/mL (range, 3.5–41 ng/mL), p=0.014] and urine NGAL/creatinine ratio [39.3 ng/mg (range, 21.1–126.3 ng/mg) vs. 11.8 ng/mg (range, 6.3–40.9 ng/mg), p=0.03] compared with those of controls and higher urine NGAL levels compared with that of diabetic adolescents with low-normal albuminuria [n=40, 11.2 ng/mL (range, 6–23.4 ng/mL), p=0.004].
Conclusions: Normoalbuminuric and normotensive adolescents with type 1 diabetes have elevated urinary NGAL values, which might indicate kidney injury.
Keywords: adolescent; ambulatory blood pressure measurement; microalbuminuria; neutrophil gelatinase-associated lipocalin; type 1 diabetes
Received: 2011-12-20
Accepted: 2012-3-24
Published Online: 2012-05-10
Published in Print: 2012-06-01
©2012 by Walter de Gruyter Berlin Boston
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Keywords for this article
adolescent;
ambulatory blood pressure measurement;
microalbuminuria;
neutrophil gelatinase-associated lipocalin;
type 1 diabetes
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