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Environmental and genetic factors influence age at menarche in women with polycystic ovary syndrome
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Jessica Carroll
Published/Copyright:
April 19, 2012
Abstract
Objective: We hypothesized that body mass index (BMI) and DNA variants would predict age at menarche in polycystic ovarian syndrome (PCOS).
Subjects: Subjects aged 18–45 years with PCOS defined by the National Institutes of Health criteria (n=522) and controls with regular menstrual cycles and no hyperandrogenism (n=472) were studied.
Methods: Age at menarche was compared between PCOS cases and controls and examined as a function of multiple parameters.
Results: There was a strong inverse relationship between BMI and age at menarche in PCOS (r=–0.32, p=5×10–11). The chromosome 6 rs7759938-T variant was associated with earlier age at menarche in women with PCOS (12.60±0.09 vs. 13.41±0.23 years; genotype TT vs. CC; p=0.006). Age at menarche was predicted by PCOS status (β=0.512, p<0.001), reported weight group at 10–14 years (β=–0.432, p<0.001), current BMI (β=–0.0202, p=0.01), and genotype (β=0.169, p=0.02).
Conclusions: Age at menarche in women with PCOS is influenced by BMI and genetic variants near LIN28B.
Received: 2012-2-17
Accepted: 2012-3-10
Published Online: 2012-04-19
Published in Print: 2012-06-01
©2012 by Walter de Gruyter Berlin Boston
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