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Growth failure in children with cystic fibrosis
-
Alessandra Scaparrotta
,
Sabrina Di Pillo
Veröffentlicht/Copyright:
11. Mai 2012
Abstract
Poor linear growth and inadequate weight gain are very common problems in cystic fibrosis (CF) children. The most important factors involved in growth failure are undernutrition or malnutrition, chronic inflammation, lung disease, and corticosteroid treatment. Nutritional support and pharmacological therapy with recombinant human growth hormone are essential for a good management of children with CF, although these children are shorter and lighter than healthy children, and despite the catch-up growth observed after diagnosis, deficit in length/height and weight continues to be seen until adulthood. Early diagnosis is essential to ensure better nutritional status and growth, potentially associated with better respiratory function and prognosis. The aims of this review are try to explain etiology and pathogenetic mechanisms of growth failure in CF children and clarify their role in the disease morbidity and in clinical outcome, especially in relation to progressive decline of pulmonary function.
Received: 2012-1-17
Accepted: 2012-4-2
Published Online: 2012-05-11
Published in Print: 2012-06-01
©2012 by Walter de Gruyter Berlin Boston
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Schlagwörter für diesen Artikel
cystic fibrosis;
growth failure;
growth hormone;
nutritional support;
pathogenesis
Artikel in diesem Heft
- Masthead
- Masthead
- Reviews
- Growth failure in children with cystic fibrosis
- Approach to the management of slipped capital femoral epiphysis and primary hyperparathyroidism
- Original Articles
- Thyroid developmental anomalies among first-degree relatives of children with thyroid dysgenesis and congenital hypothyroidism
- TSHR is the main causative locus in autosomal recessively inherited thyroid dysgenesis
- When to operate on ovarian cysts in children?
- Partial anomalous pulmonary venous return is common in Turner syndrome
- Uterine development in patients with Turner syndrome: Relation to hormone replacement therapy and karyotype
- Ovarian and uterine ultrasonography and relation to puberty in healthy girls between 6 and 16 years in the Turkish population: a cross-sectional study
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- Environmental and genetic factors influence age at menarche in women with polycystic ovary syndrome
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- Bone metabolism biomarkers, body weight, and bone age in healthy Brazilian male adolescents
- Safety and efficacy of a 1-year treatment with zoledronic acid compared with pamidronate in children with osteogenesis imperfecta
- Evaluation and comparison of safety, convenience and cost of administering intravenous pamidronate infusions to children in the home and ambulatory care settings
- Clinical profile and etiologies of children with central diabetes insipidus: a single-center experience from Turkey
- Audiologic evaluation in pediatric patients with type 1 diabetes mellitus
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- Evaluation of neutrophil gelatinase-associated lipocalin in normoalbuminuric normotensive type 1 diabetic adolescents
- The association of serum lipocalin-2 levels with metabolic and clinical parameters in obese children: a pilot study
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- Patient Reports
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- The earlier described mutation (c.307C>T [p.R103X]) in the SRD5A2 gene causing a 46,XY female phenotype
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- Meetings
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