Correction of hypoxic effects on target organs in pneumonia with phytotherapy

Alla Philippova; Raisa Aringazina; Roberto Lozano; Yuliya Tikhonova

doi:10.1515/jcim-2024-0214

Article

Correction of hypoxic effects on target organs in pneumonia with phytotherapy

Alla Philippova , Raisa Aringazina , Roberto Lozano and Yuliya Tikhonova

Published/Copyright: December 17, 2024

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From the journal Journal of Complementary and Integrative Medicine Volume 22 Issue 1

Abstract

Objectives

This study aims to investigate the molecular mechanisms of the combination of stellasterin, quercetin, and kaempferol – components of the phytopreparation ginseng (trade name Panax) – in the treatment of tissue hypoxia occurring in patients with viral and bacterial pneumoni.

Methods

An analytical single-center method of network pharmacology was utilized, involving 110 individuals divided into two subgroups: placebo and Panax phytopreparation. The therapy course lasted 2 months, after which physical (forced vital capacity, respiratory volume, oxygen saturation) and laboratory (total ATPase, Na+/K+-ATPase, glucose, leukocytes) parameters were evaluated.

Results

The administration of kaempferol, stellasterin, and quercetin increased the activity of total ATPase compared to baseline measurements in pneumonia patients with respiratory insufficiency, as well as compared to the placebo group. Thus, phytopreparations capable of controlling or limiting inflammatory reactions in various types of pneumonia and accompanying hypoxia represent promising adjunctive therapy.

Conclusions

Given the increasing incidence of viral and bacterial pneumonia, there is a growing need to develop new treatment strategies for patients and improve hypoxia outcomes.

Keywords: tissue hypoxia; oxygen deprivation; respiratory acidosis; pneumonia; ginseng; phytotherapy

Corresponding author: Roberto Lozano, Department of Pharmacy, University Clinical Hospital Lozano Blesa, Zaragoza, Spain, E-mail: robertolozano1@gmx.com

Research ethics: The study protocol was approved by the Ethics Committee of University Clinical Hospital Lozano Blesa (protocol No. 532 of 2 Apr 2020). The study was conducted in accordance with the rules of the Declaration of Helsinki.
Informed consent: All subjects gave written informed consent prior to participation.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Use of Large Language Models, AI and Machine Learning Tools: None declared.
Conflict of interests: This research has no conflict of interests.
Research funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Data availability: Not applicable.

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Received: 2024-10-28

Accepted: 2024-11-28

Published Online: 2024-12-17

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Articles in the same Issue

https://doi.org/10.1515/jcim-2024-0214

Keywords for this article

tissue hypoxia; oxygen deprivation; respiratory acidosis; pneumonia; ginseng; phytotherapy