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Terpene-based novel invasomes: pioneering cancer treatment strategies in traditional medicine

  • Renu Dwivedi , Rajni Bala EMAIL logo , Reecha Madaan , Sumitra Singh and Rakesh K. Sindhu EMAIL logo
Published/Copyright: July 12, 2024
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 22 Issue 1

Abstract

Health care workers have faced a significant challenge because of the rise in cancer incidence around the world during the past 10 years. Among various forms of malignancy skin cancer is most common, so there is need for the creation of an efficient and safe skin cancer treatment that may offer targeted and site-specific tumor penetration, and reduce unintended systemic toxicity. Nanocarriers have thus been employed to get around the issues with traditional anti-cancer drug delivery methods. Invasomes are lipid-based nanovesicles having small amounts of terpenes and ethanol or a mixture of terpenes and penetrate the skin more effectively. Compared to other lipid nanocarriers, invasomes penetrate the skin at a substantially faster rate. Invasomes possess a number of advantages, including improved drug effectiveness, higher compliance, patient convenience, advanced design, multifunctionality, enhanced targeting capabilities, non-invasive delivery methods, potential for combination therapies, and ability to overcome biological barriers,. These attributes position invasomes as a promising and innovative platform for the future of cancer treatment. The current review provides insights into invasomes, with a fresh organizational scheme and incorporates the most recent cancer research, including their composition, historical development and methods of preparation, the penetration mechanism involving effect of various formulation variables and analysis of anticancer mechanism and the application of invasomes.

Keywords: invasomes; cancer; terpenes; ethanol; phospholipids; nano-vesicles
Corresponding authors: Rajni Bala, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India, E-mail: ; and Rakesh K. Sindhu, School of Pharmacy, Sharda University, Gautam Buddha Nagar, Greater Noida, Uttar Pradesh, 201310, India, E-mail:

Acknowledgments

The authors are thankful to Chitkara College of Pharmacy, Chitkara University, Punjab, India for providing various resources to complete the current article.

  1. Research ethics: Not applicable.

  2. Informed consent: Not applicable.

  3. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  4. Competing interests: The authors state no conflict of interest.

  5. Research funding: None declared.

  6. Data availability: Within the manuscript.

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Received: 2024-04-25
Accepted: 2024-06-20
Published Online: 2024-07-12

© 2024 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Terpene-based novel invasomes: pioneering cancer treatment strategies in traditional medicine
  4. Mind-body practices for people living with dementia and their family carers: a systematic review
  5. Methodological advances in formulation and assay of herbal resources-based topical drug delivery systems
  6. Research Articles
  7. A potential therapeutic role of resveratrol in mitigating hepatotoxicity induced by paracetamol and alcohol
  8. A preclinical study on effect of betanin on sodium fluoride induced hepatorenal toxicity in Wistar rats
  9. Phytochemical characterization and evaluation of the biological activity spectrum of ethanolic fruit extract of Garcinia indica: a less explored plant of Ayurveda
  10. Scientific investigation on antibacterial, antioxidant, cytotoxic effects and TLC bioautography of Terminalia schimperiania stem bark extracts
  11. Albizia ferruginea (Guill. & Perr.) Benth. leaf abates deregulation of P53, IRS, HsD17β2, FTO, and CYP11a genes in polycystic ovarian syndrome rat
  12. Vernonia amygdalina aqueous leaf extract modulates metformin pharmacokinetics, inhibits CYP3A4 and CYP2C9 enzymes in streptozotocin-induced diabetic rats
  13. Quantitative determination of the antibacterial activity of licorice (Glycyrrhiza glabra) and tetracycline gel against Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg) and Prevotella intermedia (Pi) – a microbiological in vitro study
  14. In-silico screening of bioactive compounds of Moringa oleifera as potential inhibitors targeting HIF-1α/VEGF/GLUT-1 pathway against breast cancer
  15. Isolation, structural characterization, and molecular docking studies on the bioactive compound from n-Hexane extract of Emilia sonchifolia (L.) DC against the pancreatic cancer target Aurora 2 Kinase
  16. The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial
  17. Evaluation of gastric tolerability for long-term use of diclofenac and celecoxib in male albino rats and potential gastroprotective benefits of royal jelly: a randomized controlled trial
  18. The efficacy of thread embedding acupuncture on pain score, neck disability index, and pressure pain threshold for myofascial pain therapy in the upper trapezius muscle
  19. Correction of hypoxic effects on target organs in pneumonia with phytotherapy
https://doi.org/10.1515/jcim-2024-0131
Keywords for this article
invasomes; cancer; terpenes; ethanol; phospholipids; nano-vesicles

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Terpene-based novel invasomes: pioneering cancer treatment strategies in traditional medicine
  4. Mind-body practices for people living with dementia and their family carers: a systematic review
  5. Methodological advances in formulation and assay of herbal resources-based topical drug delivery systems
  6. Research Articles
  7. A potential therapeutic role of resveratrol in mitigating hepatotoxicity induced by paracetamol and alcohol
  8. A preclinical study on effect of betanin on sodium fluoride induced hepatorenal toxicity in Wistar rats
  9. Phytochemical characterization and evaluation of the biological activity spectrum of ethanolic fruit extract of Garcinia indica: a less explored plant of Ayurveda
  10. Scientific investigation on antibacterial, antioxidant, cytotoxic effects and TLC bioautography of Terminalia schimperiania stem bark extracts
  11. Albizia ferruginea (Guill. & Perr.) Benth. leaf abates deregulation of P53, IRS, HsD17β2, FTO, and CYP11a genes in polycystic ovarian syndrome rat
  12. Vernonia amygdalina aqueous leaf extract modulates metformin pharmacokinetics, inhibits CYP3A4 and CYP2C9 enzymes in streptozotocin-induced diabetic rats
  13. Quantitative determination of the antibacterial activity of licorice (Glycyrrhiza glabra) and tetracycline gel against Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg) and Prevotella intermedia (Pi) – a microbiological in vitro study
  14. In-silico screening of bioactive compounds of Moringa oleifera as potential inhibitors targeting HIF-1α/VEGF/GLUT-1 pathway against breast cancer
  15. Isolation, structural characterization, and molecular docking studies on the bioactive compound from n-Hexane extract of Emilia sonchifolia (L.) DC against the pancreatic cancer target Aurora 2 Kinase
  16. The impact of Omega-3 supplementation on arrhythmia reduction in acute coronary syndrome patients: a randomized clinical trial
  17. Evaluation of gastric tolerability for long-term use of diclofenac and celecoxib in male albino rats and potential gastroprotective benefits of royal jelly: a randomized controlled trial
  18. The efficacy of thread embedding acupuncture on pain score, neck disability index, and pressure pain threshold for myofascial pain therapy in the upper trapezius muscle
  19. Correction of hypoxic effects on target organs in pneumonia with phytotherapy
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