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Oleaster oil (Olea europaea sylvestris) effects on the efficiency of the reproductive system of diet-induced obese male Wistar rats

  • Kahina Hamenni , Fatima Zohra Chenni EMAIL logo , Abdelkrim Benalia , Abdelhammid Djebbar , Yassine Merad , Kheira Rebbah , Samira Meziani , Abderrahmane Belhorma , Khadidja Aberkane , Zohra Mekkiou and Onyinye Ezeh Mason
Published/Copyright: September 4, 2023
Journal of Complementary and Integrative Medicine
From the journal Journal of Complementary and Integrative Medicine Volume 20 Issue 4

Abstract

Objectives

Obesity is the result of oxidative stress (OS), which appears to be linked to male infertility. Oleaster oil has multiple therapeutic virtues due to its richness in natural bioactive compounds. This study aimed to evaluate the effect of Algerian oleaster oil on the reproductive system effectiveness of diet-induced obese male Wistar rats.

Methods

The oil was extracted with an oleodoseur from the oleaster fruits. Rats were fed for 28 weeks two diets: a normal diet (NC group, n=8) and a high-fat, high-sucrose diet (HFHS group, n=32). The obese rats in the HFHS group were then split into three groups at random: the HFHS group, which continued to receive the HFHS diet; the HFHS L-OO group; and the HFHS H-OO group, which received for 6 weeks, respectively, in combination with the HFHS diet, oleaster oil at 1.5 and 3 mL/100 g body weight (BW). Then, the animals were sacrificed. Semen and testes were removed for semen analysis, OS, and histopathological evaluation.

Results

The oleaster oil diet induces an improvement in sperm count and viability and a decrease in the percentage of fragmented sperm DNA compared to the group fed the HFHS diet, preserving the testes against OS with a highly significant decrease in testicular MDA. This beneficial effect of oleaster oil on the reproductive efficiency of rats fed the HFHS diet was dose-dependent.

Conclusions

The results showed that the oil decreased body weight, prevented OS and improved male reproductive indicators in HFHS-fed animals. The potential positive effects of oleaster oil on fertility biomarkers may be attributed to its ability to mitigate OS.

Keywords: Olea europaea sylvestris ; obese male; oleaster oil; reproductive system
Corresponding author: Fatima Zohra Chenni, Senior lecturer, Department of Biology, Djillali Liabes University of Sidi Bel Abbes, Faculty of Natural Sciences and life, Biotoxicology laboratory, WA 6009, Sidi Bel Abbes, Algeria, E-mail:

Acknowledgments

The authors would gratefully thank Professor Abbassia DEMMOUCHE from Djilali Liabes Sidi Bel Abbes university and Omar KHAROUBI from Oran 1 university for all the support and help.

  1. Ethical approval: The Institutional Ethical Committee for Animal Research approved the entire experiment (the ethical approval number 45/DGLPAG/DVA.SDA.14).

  2. Author contributions: Hamenni K & Chenni F.Z. designed the study. Hamenni K. performed the statistical analysis. Hamenni K & Chenni F.Z. performed the manuscript preparation. Hamenni K performed the analysis of the oil extract. Chenni F.Z. and Ezeh Mason O. participated in the manuscript editing and reviewing. All authors performed the experimental studies. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Research funding: None declared.

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Supplementary Material

This article contains supplementary material (https://doi.org/10.1515/jcim-2023-0126).

Received: 2023-05-05
Accepted: 2023-08-06
Published Online: 2023-09-04

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/jcim-2023-0126
Keywords for this article
Olea europaea sylvestris; obese male; oleaster oil; reproductive system

Articles in the same Issue

  1. Frontmatter
  2. Reviews
  3. Plants with potential anti-ulcerogenic activity and possible mechanism of actions based on their phyto-constitutional profile
  4. Ayurvedic medicine for the treatment of chronic rhinosinusitis: a systematic review of randomized and non-randomized trials
  5. The roles of HDAC with IMPDH and mTOR with JAK as future targets in the treatment of rheumatoid arthritis with combination therapy
  6. Research Articles
  7. Alterations in expression of α1-adrenergic receptors possibly are involved in prevention of age-associated apoptosis in rat hippocampus by treadmill exercise
  8. A solid lipid particle formulation of long pepper extract reduces pain and astrocyte activation in a rat model of neuropathic pain
  9. Modulation of glucose metabolism-related genes in diabetic rats treated with herbal synthetic anti-diabetic compound (α-HSA): insights from transcriptomic profiling
  10. Gastroprotective and ulcer healing effects of Nauclea pobeguinii (Rubiaceae) on experimentally induced gastric ulcers in male Wistar rats
  11. Blood pressure lowering effects of Vernonia amygdalina Del. Aqueous fraction on hypertensive Wistar Kyoto rats
  12. Oleaster oil (Olea europaea sylvestris) effects on the efficiency of the reproductive system of diet-induced obese male Wistar rats
  13. Antidiarrheal activity of Bridelia ferruginea bark methanolic extract involves modulation ATPases in mice and inhibition of muscarinic acetylcholine receptor (M3) and prostaglandin E2 receptor 3 (EP3) in silico
  14. Optimization of total phenolic content, total flavonoid content and anti-gout properties of polyherbal formulation
  15. Fast improvements in functional status after osteopathic manipulative treatment based on myofascial release in patients with moderate or severe fibromyalgia: a retrospective study
  16. Causes of adverse outcomes in acute intestinal obstruction
  17. Scopoletin a potential phytochemical therapy for antitubercular treatment drug induced liver injury (ATT-DILI) model in Wistar rats
  18. Non-monotonic dose-response of di-(2-ethylhexyl) phthalate isolated from Penicillium citrinum XT6 on adipogenesis and expression of PPARγ and GLUT4 in 3T3-L1 adipocytes
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