Startseite Plants with potential anti-ulcerogenic activity and possible mechanism of actions based on their phyto-constitutional profile
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Plants with potential anti-ulcerogenic activity and possible mechanism of actions based on their phyto-constitutional profile

  • Ekta S. Keny und Pravin Popatrao Kale EMAIL logo
Veröffentlicht/Copyright: 14. Februar 2022
Journal of Complementary and Integrative Medicine
Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 20 Heft 4

Abstract

Gastric ulcer, the most common disorder of the digestive tract is formed due to an imbalance between acid and mucus content of the stomach. However, the currently used western therapeutic regimens have many drawbacks like adverse effects, recurrence of gastric ulcers, are expensive, and also, may have interactions with other drugs. Hence, there is a need for effective alternative therapy. Medicinal herbs have been used since ancient times to treat several diseases and are also evidenced to be effective against gastric ulcers. It is also evident that medicinal herbs have been proved to be equally effective or superior as compared to the existing synthetic medicines. In this review, five herbs have been taken into consideration and assumed to be effective against gastric ulcers. Abrus mollis, Korean Thistle (Cirsium japonicum var. maackii), Astralagus complanatus Bunge, Bauhinia monandra, and Embelia ribes Burm f. are the herbs whose data is been collected and reviewed for their potential gastro-protective action. Although, their side effects and toxicity profile need to be further evaluated. Hence, the purpose of this review is to gather evidence of these five medicinal herbs and their probable mechanism of action against gastric ulcers based on their phyto-constitutional profile.

Keywords: alternative therapy; gastric ulcer; medicinal herbs
Corresponding author: Dr. Pravin Popatrao Kale, Department of Pharmacology, SVKM’S Dr. Bhanuben Nanavati College of Pharmacy, Gate No. 1, Mithibai College Campus, 1st floor, V.L. Mehta Road, Vile Parle (W), Mumbai 400 056, India, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

  4. Conflict of interest: None declared.

  5. Employment or leadership: None declared.

  6. Honorarium: None declared.

References

1. Vimala, G, Gricilda Shoba, F. A review on antiulcer activity of few Indian medicinal plants. Int J Microbiol 2014:1–14. https://doi.org/10.1155/2014/519590.Suche in Google Scholar PubMed PubMed Central

2. Malfertheiner, P, Chan, FK, McColl, KEL. Peptic ulcer disease. Lancet 2009;374:1449–61. https://doi.org/10.1016/s0140-6736(09)60938-7.Suche in Google Scholar PubMed

3. Bhowmik, D, Chiranjib, Tripathi, KK, Pankaj, Kumar, KPS. Recent trends of treatment and medication peptic ulcerative disorder. Int J PharmTech Res 2010;2:970–80.Suche in Google Scholar

4. Vonkeman, HE, Klok, RM, Postma, MJ, Brouwers, JRBJ, van de Laar, MAFJ. Direct medical costs of serious gastrointestinal ulcers among users of NSAIDs. Drugs Aging 2007;24:681–90. https://doi.org/10.2165/00002512-200724080-00005.Suche in Google Scholar PubMed

5. Bafna, P, Balaraman, R. Anti-ulcer and antioxidant activity of DHC-1, a herbal formulation. J Ethnopharmacol 2004;90:123–7. https://doi.org/10.1016/j.jep.2003.09.036.Suche in Google Scholar PubMed

6. Sung, JJY, Kuipers, EJ, El-Serag, HB. Systematic review: the global incidence and prevalence of peptic ulcer disease. Aliment Pharmacol Ther 2009;29:938–46. https://doi.org/10.1111/j.1365-2036.2009.03960.x.Suche in Google Scholar PubMed

7. Bi, WP, Man, HB, Man, MQ. Efficacy and safety of herbal medicines in treating gastric ulcer: a review. World J Gastroenterol 2014;20:17020–8. https://doi.org/10.3748/wjg.v20.i45.17020.Suche in Google Scholar PubMed PubMed Central

8. Yang, Y-X, Lewis, JD, Epstein, S, Metz, DC. Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA 2006;296:2947–53. https://doi.org/10.1001/jama.296.24.2947.Suche in Google Scholar PubMed

9. Janarthanan, S, Ditah, I, Adler, DG, Ehrinpreis, MN. Clostridium difficile-associated diarrhea and proton pump inhibitor therapy: a meta-analysis. Am J Gastroenterol 2012;107:1001–10. https://doi.org/10.1038/ajg.2012.179.Suche in Google Scholar PubMed

10. Famularo, G, Gasbarrone, L, Minisola, G. Hypomagnesemia and proton-pump inhibitors. Expert Opin Drug Saf 2013;12:709–16. https://doi.org/10.1517/14740338.2013.809062.Suche in Google Scholar PubMed

11. De Bruyne, P, Ito, S. Toxicity of long-term use of proton pump inhibitors in children. Arch Dis Child 2018;103:78–82. https://doi.org/10.1136/archdischild-2017-314026.Suche in Google Scholar PubMed

12. Haas, HL, Panula, P. Histamine receptors. Neuropharmacology 2016;106:1–2. https://doi.org/10.1016/j.neuropharm.2016.04.007.Suche in Google Scholar PubMed

13. Maton, PN, Burton, ME. Antacids revisited. A review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855–70. https://doi.org/10.2165/00003495-199957060-00003.Suche in Google Scholar PubMed

14. Salisbury, BH, Terrell, JM. Antacids. Treasure Island: StatPearls Publishing; 2021.Suche in Google Scholar

15. Hunt, RH, Scarpignato, C. Potassium-competitive acid blockers (P-CABs): are they finally ready for prime time in acid-related disease? Clin Transl Gastroenterol 2015;6:e119. https://doi.org/10.1038/ctg.2015.39.Suche in Google Scholar PubMed PubMed Central

16. Kagawa, T, Iwamuro, M, Ishikawa, S, Ishida, M, Kuraoka, S, Sasaki, K, et al.. Vonoprazan prevents bleeding from endoscopic submucosal dissection-induced gastric ulcers. Aliment Pharmacol Ther 2016;44:583–91. https://doi.org/10.1111/apt.13747.Suche in Google Scholar PubMed

17. Inatomi, N, Matsukawa, J, Sakurai, Y, Otake, K. Potassium-competitive acid blockers: advanced therapeutic option for acid-related diseases. Pharmacol Ther 2016;168:12–22. https://doi.org/10.1016/j.pharmthera.2016.08.001.Suche in Google Scholar PubMed

18. Mansfield, CS, Hyndman, T. Gastric cytoprotective agents. In Canine and feline gastroenterology. New York: Elsevier; 2013:500–6 pp.10.1016/B978-1-4160-3661-6.00045-6Suche in Google Scholar

19. Jewell, R. Sucralfate xPharm: the comprehensive pharmacology reference. New York: Elsevier; 2007:1–5 pp.10.1016/B978-008055232-3.62684-4Suche in Google Scholar

20. Rupesh Kumar, M, Mohamed Niyas, K, Tamizh Mani, T, Fasalu Rahiman, OM, Satya Kumar, B. A review on medicinal plants for peptic ulcer. Der Pharm Lett 2011;3:414–20.Suche in Google Scholar

21. Salisbury, BH, Terrell, JM. Antacids 2021;2. https://doi.org/10.1002/cpt196125703.Suche in Google Scholar

22. Turner, R. Antacids 1947;159:339.10.1038/159339c0Suche in Google Scholar

23. Lam, JR, Schneider, JL, Zhao, W, Corley, DA. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA J Am Med Assoc 2013;310:2435–42. https://doi.org/10.1001/jama.2013.280490.Suche in Google Scholar PubMed

24. Pension, J, Worley, KG. Adverse reactions and interactions with H2-receptor antagonists. Med Toxicol 1986;1:192–216. https://doi.org/10.1007/BF03259837.Suche in Google Scholar PubMed

25. Maes, ML, Fixen, DR, Linnebur, SA. Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence. Ther Adv Drug Saf 2017;8:273–97. https://doi.org/10.1177/2042098617715381.Suche in Google Scholar PubMed PubMed Central

26. SACHS, G, SHIN, JM, HOWDEN, CW. Review article: the clinical pharmacology of proton pump inhibitors. Aliment Pharmacol Ther 2006;23:2–8. https://doi.org/10.1111/j.1365-2036.2006.02943.x.Suche in Google Scholar PubMed

27. Murakami, K, Sakurai, Y, Shiino, M, Funao, N, Nishimura, A, Asaka, M. Vonoprazan, a novel potassium-competitive acid blocker, as a component of first-line and second-line triple therapy for Helicobacter pylori eradication: a phase III, randomised, double-blind study. Gut 2016;65:1439–46. https://doi.org/10.1136/gutjnl-2015-311304.Suche in Google Scholar PubMed PubMed Central

28. Yamasaki, A, Yoshio, T, Muramatsu, Y, Horiuchi, Y, Ishiyama, A, Hirasawa, T, et al.. Vonoprazan is superior to rabeprazole for healing endoscopic submucosal dissection: induced ulcers. Digestion 2018;97:170–6. https://doi.org/10.1159/000485028.Suche in Google Scholar PubMed

29. Fasinu, PS, Bouic, PJ, Rosenkranz, B. An overview of the evidence and mechanisms of herb–drug interactions. Front Pharmacol 2012;3:3–69. https://doi.org/10.3389/fphar.2012.00069.Suche in Google Scholar PubMed PubMed Central

30. Wachtel-Galor, S, Benzie, IFF. Herbal medicine: an introduction to its history, usage, regulation, current trends, and research needs. Boca Raton: CRC Press; 2011.Suche in Google Scholar

31. Wargovich, MJ. Anticancer properties of fruits and vegetables. HortScience 2000;35:573–5. https://doi.org/10.21273/hortsci.35.4.573.Suche in Google Scholar

32. Serafini, M, Peluso, I. Functional foods for Health: the interrelated antioxidant and anti-inflammatory role of fruits, vegetables, herbs, spices and cocoa in humans. Curr Pharm Des 2017;22:6701–15. https://doi.org/10.2174/1381612823666161123094235.Suche in Google Scholar PubMed PubMed Central

33. Rates, SM. Plants as source of drugs. Toxicon 2001;39:603–13. https://doi.org/10.1016/s0041-0101(00)00154-9.Suche in Google Scholar PubMed

34. de Almeida Andrade, F, Schlechta Portella, CF. Research methods in complementary and alternative medicine: an integrative review. J Integr Med 2018;16:6–13. https://doi.org/10.1016/j.joim.2017.12.001.Suche in Google Scholar PubMed

35. Falcão, HS, Mariath, IR, Diniz, MFFM, Batista, LM, Barbosa-Filho, JM. Plants of the American continent with antiulcer activity. Phytomedicine 2008;15:132–46. https://doi.org/10.1016/j.phymed.2007.07.057.Suche in Google Scholar PubMed

36. Palle, S, Kanakalatha, A, Kavitha, CN. Gastroprotective and antiulcer effects of Celastrus paniculatus seed oil against several gastric ulcer models in rats. J Diet Suppl 2018;15:373–85. https://doi.org/10.1080/19390211.2017.1349231.Suche in Google Scholar PubMed

37. Pinheiro, MA, Magalhães, R, Torres, D, Cavalcante, R, Mota, FX, Oliveira Coelho, EA, et al.. Gastroprotective effect of alpha-pinene and its correlation with antiulcerogenic activity of essential oils obtained from Hyptis species. Pharmacogn Mag 2015;11:123–30. https://doi.org/10.4103/0973-1296.149725.Suche in Google Scholar PubMed PubMed Central

38. Serafini, M, Peluso, I, Raguzzini, A. Flavonoids as anti-inflammatory agents. Proc Nutr Soc 2010;69:273–8. https://doi.org/10.1017/s002966511000162x.Suche in Google Scholar

39. Agati, G, Azzarello, E, Pollastri, S, Tattini, M. Flavonoids as antioxidants in plants: location and functional significance. Plant Sci 2012;196:67–76. https://doi.org/10.1016/j.plantsci.2012.07.014.Suche in Google Scholar PubMed

40. De Lira Mota, KS, Dias, GEN, Pinto, MEF, Luiz-Ferreira Â, Monteiro Souza-Brito, AR, Hiruma-Lima, CA, et al.. Flavonoids with gastroprotective activity. Molecules 2009;14:979–1012. https://doi.org/10.3390/molecules14030979.Suche in Google Scholar PubMed PubMed Central

41. Jain, P. Secondary metabolites for antiulcer activity. Nat Prod Res 2016;30:640–56. https://doi.org/10.1080/14786419.2015.1036269.Suche in Google Scholar PubMed

42. Zhang, Z, Lu, L, Liu, Y, Qing, L. Comparing and authenticating on anatomical aspects of Abrus cantoniensis and Abrus mollis by microscopy. Pharmacogn Res 2015;7:148. https://doi.org/10.4103/0974-8490.150526.Suche in Google Scholar PubMed PubMed Central

43. Miyao, H, Sakai, Y, Takeshita, T, Ito, Y, Kinjo, J, Nohara, T. Triterpene saponins from Abrus cantoniensis (Leguminosae). II. Characterization of six new saponins having a branched-chain sugar. Chem Pharm Bull (Tokyo) 1996;44:1228–31. https://doi.org/10.1248/cpb.44.1228.Suche in Google Scholar PubMed

44. Yang, M, Shen, Q, Li, LQ, Huang, YQ, Cheung, HY. Phytochemical profiles, antioxidant activities of functional herb Abrus cantoniensis and Abrus mollis. Food Chem 2015;177:304–12. https://doi.org/10.1016/j.foodchem.2015.01.054.Suche in Google Scholar PubMed

45. wen, J, Hai-Ming, shin PFtu. Research review on the main chemical constituents and pharmacological effects of Abrus mollis. Biochem Syst Ecol 2020;15:65–75.Suche in Google Scholar

46. Park, S, Hahm, K-B, Oh, T-Y, Jin, J-H, Choue, R. Preventive effect of the flavonoid, Wogonin, against ethanol-induced gastric mucosal damage in rats. Dig Dis Sci 2004;49:384–94. https://doi.org/10.1023/b:ddas.0000020490.34220.6d.10.1023/B:DDAS.0000020490.34220.6dSuche in Google Scholar PubMed

47. Shieh, DE, Liu, LT, Lin, CC. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res 2000;20:2861–5.Suche in Google Scholar

48. Wang, F, Liu, J-C, Zhou, R-J, Zhao, X, Liu, M, Ye, H, et al.. Apigenin protects against alcohol-induced liver injury in mice by regulating hepatic CYP2E1-mediated oxidative stress and PPARα-mediated lipogenic gene expression. Chem Biol Interact 2017;275:171–7. https://doi.org/10.1016/j.cbi.2017.08.006.Suche in Google Scholar PubMed

49. Salehi, B, Venditti, A, Sharifi-Rad, M, Kręgiel, D, Sharifi-Rad, J, Durazzo, A, et al.. The therapeutic potential of apigenin. Int J Mol Sci 2019;20:1305. https://doi.org/10.3390/ijms20061305.Suche in Google Scholar PubMed PubMed Central

50. Choi, Y, Kim, Y-J, Chae, H-S, Chin, Y-W. In vivo gastroprotective effect along with pharmacokinetics, tissue distribution and metabolism of isol iquiritigenin in mice. Planta Med 2015;81:586–93. https://doi.org/10.1055/s-0035-1545914.Suche in Google Scholar PubMed

51. Tanigawa, T, Nadatani, Y, Shimada, S, Sugimura, N, Itani, S, Otani, K, et al.. Isoliquiritigenin, A flavonoid component of licorice, accelerate healing of gastric ulcer through inhibition of NLRP3 inflammasome activation. Gastroenterology 2017;152:S886. https://doi.org/10.1016/s0016-5085(17)33029-9.Suche in Google Scholar

52. Kim, D-C, Choi, S-Y, Kim, S-H, Yun, B-S, Yoo, I-D, Reddy, NRP, et al.. Isoliquiritigenin selectively inhibits H 2 histamine receptor signalling. Mol Pharmacol 2006;70:493–500. https://doi.org/10.1124/mol.106.023226.Suche in Google Scholar PubMed

53. Chung, J, Hsia, T, Kuo, H, Li, Y, Lee, Y, Lin, S, et al.. Inhibitory actions of luteolin on the growth and arylamine N-acetyltransferase activity in strains of Helicobacter pylori from ulcer patients. Toxicol Vitr 2001;15:191–8. https://doi.org/10.1016/s0887-2333(01)00015-7.Suche in Google Scholar PubMed

54. Min, YS, Bai, KL, Yim, SH, Lee, YJ, Song, HJ, Kim, JH, et al.. The effect of luteolin-7-O-β-d-glucuronopyranoside on gastritis and esophagitis in rats. Arch Pharm Res 2006;29:484–9. https://doi.org/10.1007/bf02969421.Suche in Google Scholar

55. Silvéria, SR, Rao, VS, Carvalho, ACS, Guedes, MM, De Morais, TC, De Souza, AL, et al.. Gastroprotective effect of lupeol on ethanol-induced gastric damage and the underlying mechanism. Inflammopharmacology 2009;17:221–8. https://doi.org/10.1007/s10787-009-0009-9.Suche in Google Scholar PubMed

56. Odabasoglu, F, Cakir, A, Suleyman, H, Aslan, A, Bayir, Y, Halici, M, et al.. Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats. J Ethnopharmacol 2006;103:59–65. https://doi.org/10.1016/j.jep.2005.06.043.Suche in Google Scholar PubMed

57. Liu, J. Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 1995;49:57–68. https://doi.org/10.1016/0378-8741(95)90032-2.Suche in Google Scholar

58. Khan, MSA, Khundmiri, SUK, Khundmiri, SR, Al-Sanea, MM, Mok, PL. Fruit-derived polysaccharides and terpenoids: recent update on the gastroprotective effects and mechanisms. Front Pharmacol 2018;9:569. https://doi.org/10.3389/fphar.2018.00569.Suche in Google Scholar

59. Rodríguez, J. Oleanolic acid promotes healing of acetic acid-induced chronic gastric lesions in rats. Pharmacol Res 2003;48:291–4.10.1016/S1043-6618(03)00155-5Suche in Google Scholar

60. Onwuchekwa, C, Oluwole, FS. Anti-gastric ulcer effect of betulinic acid in male albino rats. Niger J Physiol Sci 2015;30:33–7.Suche in Google Scholar

61. do Nascimento, R, de Sales, I, de Oliveira Formiga, R, Barbosa-Filho, J, Sobral, M, Tavares, J, et al.. Activity of alkaloids on peptic ulcer: What’s new? Molecules 2015;20:929–50. https://doi.org/10.3390/molecules20010929.Suche in Google Scholar

62. Antonisamy, P, Arasu, MV, Dhanasekaran, M, Choi, KC, Aravinthan, A, Kim, NS, et al.. Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms. Food Funct 2016;7:398–408. https://doi.org/10.1039/c5fo00403a.Suche in Google Scholar

63. Yan, W, Han, Q, Guo, P, Wang, C, Zhang, Z. Simultaneous detection of flavonoids, phenolic acids and alkaloids in Abri Herba and Abri Mollis Herba using liquid chromatography tandem mass spectrometry. Phytochem Anal 2016;27:50–6. https://doi.org/10.1002/pca.2598.Suche in Google Scholar

64. Gurbuz, I, Erdemoglu, N, Yesilada, E, Sener, B. Anti-ulcerogenic lignans from Taxus baccata L. Z Naturforsch C Biosci 2004;59:233–6. https://doi.org/10.1515/znc-2004-3-420.Suche in Google Scholar

65. Song, SH, Kim, JE, Sung, JE, Lee, HA, Yun, WB, Lee, YH, et al.. Anti-ulcer effect of Gallarhois extract with anti-oxidant activity in an ICR model of ethanol/hydrochloride acid-induced gastric injury. J Tradit Complement Med 2019;9:372–82. https://doi.org/10.1016/j.jtcme.2017.07.001.Suche in Google Scholar

66. Kore, KJ. Evaluation of analgesic activity of castor oil in experimental models. Int J Res Ayurveda Pharm 2011;1:73–80.Suche in Google Scholar

67. Yuan, XJ, Zhang, P, Li, CY, Huo, WZ, Lu, XE, Wu, YH. One new truxillic amide compound from Abrus mollis leaves. Yaoxue Xuebao 2016;51:1595–9.Suche in Google Scholar

68. Yeon Park, J, Young Kim, H, Shibamoto, T, Su Jang, T, Cheon Lee, S, Suk Shim, J, et al.. Beneficial effects of a medicinal herb, Cirsium japonicum var. maackii, extract and its major component, cirsimaritin on breast cancer metastasis in MDA-MB-231 breast cancer cells. Bioorg Med Chem Lett 2017;27:3968–73. https://doi.org/10.1016/j.bmcl.2017.07.070.Suche in Google Scholar

69. Wagle, A, Seong, SH, Shrestha, S, Jung, HA, Choi, JS. Korean thistle (Cirsium japonicum var. maackii (Maxim.) Matsum.): a potential dietary supplement against diabetes and Alzheimer’s disease. Molecules 2019;24:649. https://doi.org/10.3390/molecules24030649.Suche in Google Scholar

70. Ali, F, Rahul, Naz, F, Jyoti, S, Siddique, YH. Health functionality of apigenin: a review. Int J Food Prop 2017;20:1197–238. https://doi.org/10.1080/10942912.2016.1207188.Suche in Google Scholar

71. Ng, Y-F, Tang, PC-T, Sham, T-T, Lam, W-S, Mok, DK-W, Chan, S-W. Semen Astragali Complanati: an ethnopharmacological, phytochemical and pharmacological review. J Ethnopharmacol 2014;155:39–53. https://doi.org/10.1016/j.jep.2014.06.013.Suche in Google Scholar PubMed

72. Cui, BL, Lu, YR, Wei, LX. Studies on chemical constituents of Astragalus complanatus R. BR. Yao Xue Xue Bao 1989;24:189–93.Suche in Google Scholar

73. Sun, L-B, Gu, Z-L, Kwok, C-Y, Wang, W-P. The protective effects of flavonoids from Astragalus complanatus on carbon tetrachloride induced hepatic fibrosis in mice. In: 2010 International Conference Bioinformatics and Biomedical Technology. IEEE; 2010:374–7 pp.10.1109/ICBBT.2010.5478936Suche in Google Scholar

74. Perveen, S, Fawzy, GA, Al-Taweel, AM, Orfali, RS, Yusufoglu, HS, Abdel-Kader, MS, et al.. Antiulcer activity of different extracts of anvillea garcinii and isolation of two new secondary metabolites. Open Chem 2018;16:437–45. https://doi.org/10.1515/chem-2018-0037.Suche in Google Scholar

75. Germanò, MP, Cacciola, F, Donato, P, Dugo, P, Certo, G, D’Angelo, V, et al.. Betula pendula Roth leaves: gastroprotective effects of an HPLC-fingerprinted methanolic extract. Nat Prod Res 2013;27:1569–75. https://doi.org/10.1080/14786419.2012.740036.Suche in Google Scholar PubMed

76. Liu, Xhua, Zhao, Lgong, Liang, J, Guo, L, Yang, Ylai, Hu, F, et al.. Component analysis and structure identification of active substances for anti-gastric ulcer effects in Radix Astragali by liquid chromatography and tandem mass spectrometry. J Chromatogr B Anal Technol Biomed Life Sci 2014;960:43–51. https://doi.org/10.1016/j.jchromb.2014.04.020.Suche in Google Scholar PubMed

77. Klein-Júnior, LC, Santin, JR, Lemos, M, Silveira, ACDO, Rocha, JAR, Beber, AP, et al.. Role of gastric mucus secretion, oxinitrergic system and sulfhydryl groups on the gastroprotection elicited by Polygala cyparissias (Polygalaceae) in mice. J Pharm Pharmacol 2013;65:767–76. https://doi.org/10.1111/jphp.12038.Suche in Google Scholar PubMed

78. Jung, HJ, Choi, J, Nam, JH, Park, HJ. Anti-ulcerogenic effects of the flavonoid-rich fraction from the extract of Orostachys japonicus in mice. J Med Food 2007;10:702–6. https://doi.org/10.1089/jmf.2006.223.Suche in Google Scholar PubMed

79. Coelho, LCBB, Da Silva, MBR. Simple method to purify milligram quantities of the galactose-specific lectin from the leaves of Bauhinia monandra. Phytochem Anal 2000;11:295–300. https://doi.org/10.1002/1099-1565(200009/10)11:5<295::aid-pca517>3.0.co;2-s.10.1002/1099-1565(200009/10)11:5<295::AID-PCA517>3.0.CO;2-SSuche in Google Scholar

80. Abo, K, Jimoh, T. Anti-hyperglycaemic potential of stem Bark of Bauhinia monandra Kurz in rats. Niger J Nat Prod Med 2005;8:48–51. https://doi.org/10.4314/njnpm.v8i1.11815.Suche in Google Scholar

81. Aderogba, MA, Ogundaini, AO, Eloff, JN. Isolation of two flavonoids from Bauhinia monandra (Kurz) leaves and their antioxidative effects. Afr J Tradit Complement Altern Med 2006;3:59–65. https://doi.org/10.4314/ajtcam.v3i4.31177.Suche in Google Scholar

82. Nworie, KM, Okorie, NA. Phytochemicals distribution and antioxidant potential of Bauhinia monandra (linn.) leaves extract. Res J Med Plant 2018;12:78–83. https://doi.org/10.3923/rjmp.2018.78.83.Suche in Google Scholar

83. Ö, C, Kanter, M, Armutçu, F, Çetin, K, Kaybolmaz, B, Yazgan, Ö. Protective effects of quercetin, a flavonoid antioxidant, IN absolute ethanol-induced acute gastric ulcer. Electron J Gen Med 2004;1:37–42.10.29333/ejgm/82201Suche in Google Scholar

84. Narayanamurthy, U, Jayachandran, R, Ramarajan, SC, Kumarappan, M. Effect of quercetin on histamine induced gastric ulcers in male Guinea pigs. Int J Basic Clin Pharmacol 2019;8:2018–23. https://doi.org/10.18203/2319-2003.ijbcp20194109.Suche in Google Scholar

85. Kotob, SES, Sayed, A, Mohamed, S, Ahmed, H. Quercetin and ellagic acid in gastric ulcer prevention: an integrated scheme of the potential mechanisms of action from in vivo study. Asian J Pharm Clin Res 2018;11:381. https://doi.org/10.22159/ajpcr.2018.v11i1.21991.Suche in Google Scholar

86. Abdel-Raheem, IT. Gastroprotective effect of rutin against indomethacin-induced ulcers in rats. Basic Clin Pharmacol Toxicol 2010;107:742–50. https://doi.org/10.1111/j.1742-7843.2010.00568.x.Suche in Google Scholar PubMed

87. Jeong, CS. Evaluation for protective effect of rutin, a natural flavonoid, against Hcl/ethanol-induced gastric lesions. Biomol Ther 2009;17:199–204. https://doi.org/10.4062/biomolther.2009.17.2.199.Suche in Google Scholar

88. Ganeshpurkar, A, Shrivastava, A, Bansal, D, Dubey, N, Dubey, S. Rutin exerts antiulcer effect by inhibiting the gastric proton pump. Indian J Pharmacol 2013;45:415–7. https://doi.org/10.4103/0253-7613.115011.Suche in Google Scholar PubMed PubMed Central

89. Alade, GO, Akanmu, MA, Obuotor, EM, Osasan, SA, Omobuwajo, OR. Acute and oral subacute toxicity of methanolic extract of Bauhinia monandra leaf in rats. African J Pharm Pharmacol 2009;3:354–8.Suche in Google Scholar

90. Lal, B, Mishra, N. Importance of Embelia ribes: an update. Int J Pharm Sci Res 2013;4:3823–38.Suche in Google Scholar

91. Krishnaswamy, M, Purushothaman, KK. Antifertility properties of Embelia ribes. Indian J Exp Biol 1980;18:638–9.Suche in Google Scholar

92. Chitra, M, Sukumar, E, Suja, V, Devi, S. Antitumor, anti-inflammatory and analgesic property of embelin, a plant product. Chemotherapy 1994;40:109–13. https://doi.org/10.1159/000239181.Suche in Google Scholar PubMed

93. Ambati, S, Jyothi, AV. Pharmacology, pharmacognostic and phytochemical review of Embelia ribes. Int J Pharm Technol IJPT 2010;2:525–39.Suche in Google Scholar

94. Kamble, V, Attar, U, Umdale, S, Nimbalkar, M, Ghane, S, Gaikwad, N. Phytochemical analysis, antioxidant activities and optimized extraction of embelin from different genotypes of Embelia ribes Burm f.: a woody medicinal climber from Western Ghats of India. Physiol Mol Biol Plants 2020;26:1855–65. https://doi.org/10.1007/s12298-020-00859-2.Suche in Google Scholar PubMed PubMed Central

95. Kumar, S, Deshmukh, R. Embelin as a potential drug molecule: a review. J Pharmacogn Nat Prod 2017;3:144–50. https://doi.org/10.4172/2472-0992.1000144.Suche in Google Scholar

96. Souza, MOD, Gushiken, LFS, Beserra, FP, Pellizzon, CH. Evaluation of the gastroprotective and antioxidant effects of caffeine and caffeic acid on ethanol- induced gastric ulcer. JSM Hepat 2017;2:1008.Suche in Google Scholar

97. Calixto-Campos, C, Carvalho, TT, Hohmann, MSN, Pinho-Ribeiro, FA, Fattori, V, Manchope, MF, et al.. Vanillic acid inhibits inflammatory pain by inhibiting neutrophil recruitment, oxidative stress, cytokine production, and NFκB activation in mice. J Nat Prod 2015;78:1799–808. https://doi.org/10.1021/acs.jnatprod.5b00246.Suche in Google Scholar

98. Shimoyama, AT, Santin, JR, Machado, ID, de Oliveira e Silva, AM, de Melo, ILP, Mancini-Filho, J, et al.. Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer. Naunyn Schmiedebergs Arch Pharmacol 2013;386:5–14. https://doi.org/10.1007/s00210-012-0807-2.Suche in Google Scholar

99. Jung, J, Lee, J-H, Bae, KH, Jeong, C-S. Anti-gastric actions of eugenol and cinnamic acid isolated from Cinnamomi ramulus. Yakugaku Zasshi 2011;131:1103–10. https://doi.org/10.1248/yakushi.131.1103.Suche in Google Scholar

100. Balachandran, C, Duraipandiyan, V, Balakrishna, K, Sundaram, RL, Vijayakumar, A, Ignacimuthu, S, et al.. Synthesis and medicinal properties of plant-derived vilangin. Environ Chem Lett 2013;11:303–8. https://doi.org/10.1007/s10311-013-0408-4.Suche in Google Scholar

101. Lal, B, Mishra, N. Importance of Embelia ribes: an update international journal of pharmaceutical sciences and research. Int J Pharm Sci Res 2013:3823–38.Suche in Google Scholar

102. Srivastava, R, Srivastava, S, Singh, SP. Toxicological screening for polyherbal combinations of Moringa oleifera and Embelia ribes in experimental animals. Asian J Pharm Clin Res 2018;11:476–80. https://doi.org/10.22159/ajpcr.2018.v11i7.26482.Suche in Google Scholar

103. Fitzgerald, JB, Schoeberl, B, Nielsen, UB, Sorger, PK. Systems biology and combination therapy in the quest for clinical efficacy. Nat Chem Biol 2006;2:458–66. https://doi.org/10.1038/nchembio817.Suche in Google Scholar

104. Yuan, H, Ma, Q, Cui, H, Liu, G, Zhao, X, Li, W, et al.. How can synergism of traditional medicines benefit from Network pharmacology? Molecules 2017;22:1135. https://doi.org/10.3390/molecules22071135.Suche in Google Scholar
Received: 2021-06-21
Accepted: 2021-12-20
Published Online: 2022-02-14

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Plants with potential anti-ulcerogenic activity and possible mechanism of actions based on their phyto-constitutional profile
  4. Ayurvedic medicine for the treatment of chronic rhinosinusitis: a systematic review of randomized and non-randomized trials
  5. The roles of HDAC with IMPDH and mTOR with JAK as future targets in the treatment of rheumatoid arthritis with combination therapy
  6. Research Articles
  7. Alterations in expression of α1-adrenergic receptors possibly are involved in prevention of age-associated apoptosis in rat hippocampus by treadmill exercise
  8. A solid lipid particle formulation of long pepper extract reduces pain and astrocyte activation in a rat model of neuropathic pain
  9. Modulation of glucose metabolism-related genes in diabetic rats treated with herbal synthetic anti-diabetic compound (α-HSA): insights from transcriptomic profiling
  10. Gastroprotective and ulcer healing effects of Nauclea pobeguinii (Rubiaceae) on experimentally induced gastric ulcers in male Wistar rats
  11. Blood pressure lowering effects of Vernonia amygdalina Del. Aqueous fraction on hypertensive Wistar Kyoto rats
  12. Oleaster oil (Olea europaea sylvestris) effects on the efficiency of the reproductive system of diet-induced obese male Wistar rats
  13. Antidiarrheal activity of Bridelia ferruginea bark methanolic extract involves modulation ATPases in mice and inhibition of muscarinic acetylcholine receptor (M3) and prostaglandin E2 receptor 3 (EP3) in silico
  14. Optimization of total phenolic content, total flavonoid content and anti-gout properties of polyherbal formulation
  15. Fast improvements in functional status after osteopathic manipulative treatment based on myofascial release in patients with moderate or severe fibromyalgia: a retrospective study
  16. Causes of adverse outcomes in acute intestinal obstruction
  17. Scopoletin a potential phytochemical therapy for antitubercular treatment drug induced liver injury (ATT-DILI) model in Wistar rats
  18. Non-monotonic dose-response of di-(2-ethylhexyl) phthalate isolated from Penicillium citrinum XT6 on adipogenesis and expression of PPARγ and GLUT4 in 3T3-L1 adipocytes
https://doi.org/10.1515/jcim-2021-0264
Schlagwörter für diesen Artikel
alternative therapy; gastric ulcer; medicinal herbs

Artikel in diesem Heft

  1. Frontmatter
  2. Reviews
  3. Plants with potential anti-ulcerogenic activity and possible mechanism of actions based on their phyto-constitutional profile
  4. Ayurvedic medicine for the treatment of chronic rhinosinusitis: a systematic review of randomized and non-randomized trials
  5. The roles of HDAC with IMPDH and mTOR with JAK as future targets in the treatment of rheumatoid arthritis with combination therapy
  6. Research Articles
  7. Alterations in expression of α1-adrenergic receptors possibly are involved in prevention of age-associated apoptosis in rat hippocampus by treadmill exercise
  8. A solid lipid particle formulation of long pepper extract reduces pain and astrocyte activation in a rat model of neuropathic pain
  9. Modulation of glucose metabolism-related genes in diabetic rats treated with herbal synthetic anti-diabetic compound (α-HSA): insights from transcriptomic profiling
  10. Gastroprotective and ulcer healing effects of Nauclea pobeguinii (Rubiaceae) on experimentally induced gastric ulcers in male Wistar rats
  11. Blood pressure lowering effects of Vernonia amygdalina Del. Aqueous fraction on hypertensive Wistar Kyoto rats
  12. Oleaster oil (Olea europaea sylvestris) effects on the efficiency of the reproductive system of diet-induced obese male Wistar rats
  13. Antidiarrheal activity of Bridelia ferruginea bark methanolic extract involves modulation ATPases in mice and inhibition of muscarinic acetylcholine receptor (M3) and prostaglandin E2 receptor 3 (EP3) in silico
  14. Optimization of total phenolic content, total flavonoid content and anti-gout properties of polyherbal formulation
  15. Fast improvements in functional status after osteopathic manipulative treatment based on myofascial release in patients with moderate or severe fibromyalgia: a retrospective study
  16. Causes of adverse outcomes in acute intestinal obstruction
  17. Scopoletin a potential phytochemical therapy for antitubercular treatment drug induced liver injury (ATT-DILI) model in Wistar rats
  18. Non-monotonic dose-response of di-(2-ethylhexyl) phthalate isolated from Penicillium citrinum XT6 on adipogenesis and expression of PPARγ and GLUT4 in 3T3-L1 adipocytes
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